HOME >> BIOLOGY >> NEWS
Model for common type of cancer developed by UCLA scientists

Scientists at UCLA's Jonsson Cancer Center have developed the world's first animal model for mature human B-cell lymphomas, a discovery that may lead to the uncovering of the genetic mutations that cause these types of cancer. Mature B-cell type lymphomas account for about 85 percent of all lymphomas.

The basic science discovery is outlined in the Oct. 29 issue of the peer-reviewed journal Proceedings of the National Academy of Sciences.

"What we can do now is grow cell lines out of this model to determine which cancer-causing companion mutations arise," said Dr. Mike Teitell, a physician and researcher at UCLA's Jonsson Cancer Center and the lead author of the article, available online at www.pnas.org/. "This model appears to yield a large spectrum of mature B-cell lymphomas."

Teitell, collaborator Randolph Wall, and their research team, scientist Katrina Hoyer and Dr. Samuel French, had previously identified an abnormality in a gene called T-cell leukemia 1 (TCL1) in patients with B-cell lymphomas, especially in those suffering from AIDS.

The researchers wondered what would happen if they developed an animal model with abnormally expressed TCL1 -- would the model develop cancer? Teitell and his team got more than they expected: animals with abnormally regulated TCL1 developed three different types of lymphoma.

"This finding suggested that specific mutations in addition to TCL1 were causing distinct types of B-cell malignancy. It was a very surprising result," Teitell said "Before this, we did not have a model for any of these forms of lymphoma. Since we can now generate all these different types, we are in a position to understand the changes that cause each type. For example, why does one animal with abnormal TCL1 expression develop one type of lymphoma, while a genetically identical animal develops a different type?"

B-cell lymphomas include both Hodgkin's and non-Hodgkin's ly
'"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
29-Oct-2002


Page: 1 2 3

Related biology news :

1. Applied Mathematical Models in Human Physiology
2. Model shows long-held constant in ocean nutrient ratio may vary as ecological conditions change
3. Models help estimate childrens exposure to toxins
4. Models show gene flow from crops threatens wild plants
5. U.S. - FSU Partnering Models
6. Modeling human lung cancer
7. The Chemical Leupeptin Protects Against Noise-Induced Hearing Loss In Animal Model, UB Hearing Researchers Show
8. Molecular Modeling Expands Chemistry Students Experiences
9. Model Polymers Reveal New Clues to Protein Folding
10. How Nerve Cells Get In Touch - A Molecular Model Of Synapse Formation And Retrograde Signalling In The Brain
11. Duke Geologist Decries Using Engineering Models To Predict Natural Phenomena

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... PHOENIX (PRWEB) , ... July 03, 2020 , ... ... is proud to earn outstanding recognition and multiple awards for not only the ... the ABM portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... software solutions for biopharmaceutical R&D, today announced that it has entered into ... full-length multispecific antibodies (Multiclonics®), to support their translational and clinical research strategy ...
(Date:6/23/2020)... ... , ... The field of quantitation of large molecules or proteins has been ... However, the use of mass spectrometry in this field has gained a lot of ... you choose which approach to use (LBA or MS)?” In many cases, either ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering patients ... million stem cells total, patients may choose which extremities they would like treated. , ... (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and monitoring ... did not take off as quickly as people initially expected, and where eSource is ... data electronically for clinical trials and then repurposing it for downstream analysis, at a ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this new ... only technology of its kind on the market and we were pleased that the ... capacity of traditional cultured ingredients, creating a natural way to extend the shelf life ...
(Date:7/10/2020)... HONG KONG (PRWEB) , ... July 09, 2020 ... ... chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in ... years, the PolyU research team led by Dr MA has been using the ...
Breaking Biology Technology:
Cached News: