HOME >> BIOLOGY >> NEWS
Molecular "Fossils" Of Early Life

Yale Scientists Recreate Molecular "Fossils," Now Extinct, That May Have Existed At The Beginning Of Life

Discovery Narrows Search For Precursor Of All Life Forms

New Haven, Conn. -- Yale scientists report they have synthesized molecules like those that probably gave rise to the earliest life forms on Earth nearly 4 billion years ago, thus creating a biochemist's version of "Jurassic Park" populated by exotic molecular "fossils" that have long since become extinct.

In the May 26 issue of the Proceedings of the National Academy of Sciences, the Yale biologists report the creation of one of these "fossils," an unusual hybrid molecule made up of a scaffold from deoxyribonucleic acid (DNA) with chemical "scissors" attached to it.

Ronald R. Breaker, who created the first DNA enzymes in 1994 with colleagues at The Scripps Research Institute, said he "looted the tool box of proteins" to get the amino acid "scissors," which destroy messenger ribonucleic acid (RNA) in humans and many other organisms. The feat was accomplished using a technique known as test-tube evolution.

Breaker's tailor-made enzyme is the first known nucleic acid enzyme that uses an amino acid to trigger chemical activity, and it brings scientists a step closer to finding the precursor of all life -- a single molecule containing both genetic code and an enzyme capable of triggering self-replication.

"If we can raid a protein's tool box to take one of its favored chemical groups -- in this case, a key amino acid called histidine found in a protein called RNase A -- then we should be able to raid the entire tool box and make use of anything we find there to make highly sophisticated DNA or RNA enzymes," said Breaker, who collaborated with Yale postdoctoral associate Adam Roth.

Which Came First -- DNA, RNA Or Proteins?


'"/>

Contact: Cynthia Atwood
Cynthia.Atwood@yale.edu
203-432-1326
Yale University
5-Jun-1998


Page: 1 2 3 4 5

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecular Fossils Early Life

(Date:11/6/2014)... deaths occur because of metastasis, yet progress in ... slow. , "It,s been particularly challenging to design ... research fellow in systems biology at Harvard Medical ... until after they,ve already metastasized." , Gujral and ... should help researchers better understand how metastasis begins. ...
(Date:11/6/2014)... 2014 - Insilico Medicine, Inc, a Baltimore-based bioinformatics ... related diseases announced a research collaboration with the ... Oncology, Inc (OTC: CSBR). , "There are many ... but Champions Oncology,s TumorGraft technology is unique in ... regimen experimentally generating vast amounts of valuable data. ...
(Date:11/5/2014)... dedicated his career to understanding the Earth,s climate ... , As deputy director and regional climatologist for ... Research Institute, Redmond has more than three decades ... of climate data to the general public. , ... Francisco on December 15-19, 2014 the American Geophysical ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
(Date:11/27/2014)... DUBLIN , Nov. 27, 2014 ... of the "Global Palmitic Acid Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 The Global Palmitic Acid ... on the current state of the global palmitic acid ... of the industry including definitions, classifications, applications and industry ...
(Date:11/26/2014)... NOVEMBER 21, 2014 (PRWEB) November 26, 2014 ... health-oriented communications network, today announced the organization has won ... Rx Club Awards. Digitas Health LifeBrands was honored with ... four other PHCG agencies received eight Awards of Excellence. ... creative aspects of pharmaceutical advertising and promotion. The Awards ...
(Date:11/26/2014)... YORK , Nov. 26, 2014 The ... may indicate the company is looking to expand in ... further sales.  The healthcare market research firm says that  ... to Kalorama Information,s biennial survey of the IVD market ... and any change in its composition would likely affect ...
(Date:11/26/2014)... PMG Research, Inc. announced today the formation ... of sites that provide clinical research services to pharmaceutical companies ... through its partnerships with large physician practices and integrated health ... in the Southeastern United States and spans over 60 physician ... will be held by: Dr. Robert Holmes, MD, of ...
Breaking Biology Technology:Global Palmitic Acid Industry Report 2014 2Publicis Healthcare Wins 20 Rx Club Awards 2Publicis Healthcare Wins 20 Rx Club Awards 3Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3
Cached News: