Molecular Circuit Breaker Can Prevent Runaway Cell Growth

signals that stimulate cells to proliferate. When the strength of these signals rises to dangerous levels, ARF relays this information to another growth inhibitory protein, p53, that in turn prevents the over-stimulated cells from growing and can even induce them to commit suicide. One protein whose levels are carefully monitored by this ARF-p53 "fail-safe" mechanism is Myc, a protein that is required for normal cell growth but whose unregulated overexpression can lead to cancer.

"The ARF protein controls a p53-dependent process that helps to safeguard cells against runaway growth promoting signals," Sherr says. "ARF and p53 act together to limit Myc's stimulatory potential, but in cases where ARF is damaged and can no longer function, unchecked Myc activity can cause havoc."

Sherr and Roussel collaborated with Scott W. Lowe and his colleagues at Cold Spring Harbor Laboratory, and Carol Prives at Columbia University in an attempt to further generalize these findings. The Cold Spring Harbor researchers have been studying another tumor-inducing viral gene, called E1A. They had previously found that p53 suppresses the tumor-generating activity of E1A. The new findings reveal that this ability of cells to resist E1A also depends strongly upon ARF.

Understanding how ARF works has helped to interpret the actions of what Robert Weinberg [of the Whitehead Institute for Biomedical Research at MIT] calls 'collaborating oncogenes.' This theory posits that truly normal cells resist certain oncogenes and refuse to be transformed into cancer cells.

"We have known for 15 years that genes like Myc and E1A help to overcome this resistance. Myc and E1A kill normal cells by activating the ARF-p53 checkpoint," says Sherr, "but they also select for the emergence of rare tumor cells that have lost the ARF-p53 checkpoint and no longer die." The studies on ARF's ability to counteract the effects of Myc and E1A were published in two article

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:

(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
(Date:8/29/2019)... Calif. (PRWEB) , ... August ... ... daacro (Diagnostic Assessment and Clinical Research Organization), have recently passed their ... CRO standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary focus ...
(Date:8/25/2019)... ... August 23, 2019 , ... Sierra Instruments is pleased to announce ... online store are now live. Sierra has redesigned entry to the site with both ... more user-friendly and easier to navigate with streamlined menus and simple access to resources ...
Breaking Biology News(10 mins):
(Date:9/9/2019)... ... ... Visikol CEO Dr. Michael Johnson recently gave a talk at the ... cell culture models. The inherent problem of characterizing 3D cell culture models is similar ... and therefore traditional wide-field or even confocal microscopy only tells you what is going ...
(Date:9/2/2019)... ... September 02, 2019 , ... ... in vitro diagnostics, has launched the industry’s first epigenetics data mining services that ... of epigenetic data and other data types. , Next generation sequencing in combination ...
(Date:8/27/2019)... ... ... Dr. Kim Carlson is a veterinary surgeon practicing in the bay area of ... new surgical practice in San Mateo. She is currently the only surgeon in ... the practice grows. , When asked about the opening of her new surgical practice, ...
(Date:8/23/2019)... ... August 22, 2019 , ... An ... and is scheduled to broadcast 4Q/2019. Check your local listings for more information. ... for generic drug delivery. Focusing on therapeutics for children and the elderly, viewers ...
Breaking Biology Technology:
Cached News: