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Molecular Circuit Breaker Can Prevent Runaway Cell Growth

s in the August 7, 1998, issue of Genes & Development.

While it has been known for several years that damage to a cell's DNA can signal a p53 response that induces cell suicide, these researchers have concluded that ARF sends an alternative signal that does not rely upon DNA damage. However, the ARF pathway can also act hand in hand with the DNA damage pathway in triggering p53-induced cell suicide. According to both Sherr and Lowe, drugs designed to emulate ARF or stimulate ARF production might make cells more sensitive to the many conventional forms of anti-cancer therapy that act by damaging the DNA of tumor cells.


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Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
7-Aug-1998


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