Molecular Control Mechanism Of Embryonic Development Unraveled

National Science Foundation (NSF)-funded researchers at the Johns Hopkins School of Medicine in Baltimore, Maryland, and at California's Stanford University have shed new light on the molecular switches that control the complex process by which a single fertilized egg develops into a mature organism. Their paper is published in the February 19, 1999, issue of the journal Cell.

In humans and other mammals, the process is orchestrated in the developing embryo by a set of proteins called "Hox proteins" that control the timely expression of genes -- and thereby control the production of the "next stage" proteins needed for embryonic development. The action of Hox proteins must, in turn, be coordinated to assure the accurate development of an embryo; that coordination involves another set of proteins that act as molecular choreographers.

"Failure of the molecular systems that control development prevents normal embryonic growth, and alterations in these control systems can lead to a wide variety of cancers," explains Kamal Shukla, program director in NSF's division of cellular and molecular biosciences, which funds the research. "Understanding the molecular mechanisms that control normal embryonic development is the first step in developing strategies to prevent these errors, or to repair them when they have gone wrong." Cynthia Wolberger at Johns Hopkins and Michael Cleary at Stanford have made a major step forward in the understanding of these crucial molecular events, Shukla believes.

This research, which uses x-ray crystallography, has led to the determination of the atomic structure of "HoxB1" and a protein called Pbx1, all bound to a fragment of DNA. Pbx1 plays a central role in the modulation of Hox protein function, and mutations in it have been implicated in some childhood leukemias. By visualizing how Pbx1 interacts with a Hox protein and with DNA, Wolberger and colleagues have determined the precise way in which the proteins interact

Contact: Cheryl Dybas
National Science Foundation

Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:

(Date:6/5/2020)... ... June 04, 2020 , ... Murrieta Genomics ... new patent application for simplified sample preparation for Next Generation Genomic Sequencing (NGS) ... reduce cost, time, and complexity of sample preparation. , “I have been at the ...
(Date:6/5/2020)... ... ... Greffex, a pioneering vaccine and gene therapy company based in Houston, Texas, welcomes Mr. ... global perspective to make an impact in a post pandemic world,” said Co-Chairman John ... director of the company. , “The Greffex board is excited to have Neil as ...
(Date:5/30/2020)... ... May 29, 2020 , ... ... transformation for enterprises globally, has collaborated with EchoNous Inc. to develop the cloud-based ... can measure systolic heart function, which has been clinically tested versus expert measurements, ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... ... announced Jim Corrigan, President and CEO has been named one of the 100 ... of industry sectors, PharmaVoice 100 honorees are selected based on how they have ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, ... that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... or two switches in a push-pull configuration; yielding fast fall time for a ...
(Date:7/31/2020)... ... 29, 2020 , ... The SDX® Respiratory Gating System ... has reached its 20th anniversary of worldwide use. Introduced in the US over ... including University of Pennsylvania, University of Michigan, University of Maryland, University of California ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this new technology ... technology of its kind on the market and we were pleased that the IFT ... of traditional cultured ingredients, creating a natural way to extend the shelf life and ...
Breaking Biology Technology:
Cached News: