Molecular Effect Of Vitamin E On Plaque Formation Identified

DALLAS - April 9, 1999 - Furthering evidence of the importance of vitamin E, researchers at UT Southwestern Medical Center at Dallas have identified the pathway that may allow the vitamin to block the trigger of arterial plaque formation at the molecular level.

As an antioxidant, vitamin E prevents the oxidation of low-density lipoproteins (LDL), the so-called "bad" cholesterol that contributes to heart disease. But research by Dr. Ishwarlal Jialal, professor of pathology and internal medicine, and Dr. Sridevi Devaraj, pathology instructor at UT Southwestern, also has found it to be a powerful player on the molecular level. Their latest work, published in the April 8th issue of Arteriosclerosis, Thrombosis and Vascular Biology, establishes for the first time that vitamin E inhibits the activity of an enyzme, 5-lipoxygenase, which is key to the initiation of plaque formation.

"Mounting evidence suggests that plaque formation is an inflammatory process," Devaraj said. This enzyme, 5-lipozygenase, produces a substance that stimulates the release of the protein interleukin-1beta (IL-1beta), which promotes plaque formation. Studies have shown it stimulates adhesion of white blood cells or monocytes to the arterial lining, promotes uptake of cholesterol by the cells and stimulates smooth-muscle-cell proliferation. Also, increased levels of IL-1beta have been observed in the coronary arteries of patients with heart disease and have been shown to correlate with the severity of the plaque.

"This is the first study showing that vitamin E has a novel biological anti-inflammatory effect on this crucial enzyme in cells that is more than just an antioxidant effect," Jialal said. "This pioneering work sheds more light on the possible prevention of heart disease with this antioxidant supplement, by decreasing not only oxidation of bad cholesterol but also by having important effects on cell function in the plaque."

In a 1996 study, these researchers showed that

Contact: Bridgette McNeill
UT Southwestern Medical Center

Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:

(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/18/2017)... a global expert in SoC-based imaging and computing solutions, has developed ... the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® , ... showcased during the upcoming Medtec Japan at Tokyo Big Sight April ... Vegas Convention Center April 24-27. ... Click here for an image of the M820 ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... (ADC) therapeutics, today confirmed licensing rights that give it exclusive global access ... developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, an ...
(Date:10/10/2017)... -- International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... market and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase ... "The residential security market has experienced continued growth, ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
Breaking Biology Technology:
Cached News: