HOME >> BIOLOGY >> NEWS
Molecular Imposter Rebuts Long

Ever since Watson and Crick first cracked the structure of DNA in 1953, biochemists have speculated that hydrogen bonding between DNA's four bases plays a key role in the amazing accuracy of this genetic blueprint. But new research with a molecular imposter is calling some of these long-held beliefs into question. Results presented in the February 12 issue of the Journal of the American Chemical Society suggest strongly that the precision of DNA copying has much more to do with DNA's shape and the enzymes that copy it.

This finding brings into question decades of dogma on DNA replication, says researcher Eric Kool of the University of Rochester. Kool adds that the new information may help researchers develop new drugs that are better able to sneak in and kill sickly cells -- including deadly cancer cells.

Kool and co-workers created a ring-like molecule that very closely mimics the shape of the base thymine in DNA. This thymine mimic lacks the slightly charged regions needed to form hydrogen bonds with thymine's normal partner base, adenine. But when the mimic was placed into a strand of DNA, the scientists got a surprise: The cell's DNA-copying machinery correctly inserted adenine opposite the thymine-like base despite the absence of hydrogen bonds. Not only was adenine inserted opposite the thymine mimic, it was inserted correctly nearly all the time -- suggesting that base shape is more important than hydrogen bonds in ensuring accurate DNA replication.

"Most biochemistry textbooks cite hydrogen bonds as the primary reason that DNA is copied accurately," says Kool, a professor of chemistry. "Because of this finding, the next generation of texts may not be able to say that."

Hydrogen bonds form because of slight charge differences between the atoms that make up adjacent molecules. Each of the four DNA bases -- adenine, thymine, cytosine, and guanine -- has a characteristic arrangement of these partially charged atoms that
'"/>

Contact: Stephen Bradt
sbradt@admin.rochester.edu
716-273-4726
University of Rochester
26-Feb-1997


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... ... mitochondria, in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology ... VISTA-2 study of SkQ1 ophthalmic solution in patients with moderate to severe ...
(Date:8/21/2020)... LEXINGTON, Mass. (PRWEB) , ... August 18, 2020 ... ... novel approaches to cell therapy, today announced that the U.S. Food and Drug ... evaluation of Sentien’s lead asset, SBI-101, for the treatment of severe COVID-19. Approval ...
(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, ... have entered into license agreements with Housey Pharma’s HMI subsidiary to gain access ... J&J have annual Research and Development spending in excess of US $10 billion. ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... aid in the early detection and prevention of high-burden diseases, and Centric Consulting, ... hospitals and healthcare organizations to utilize existing data in order to identify and ...
(Date:7/10/2020)... LEXINGTON, Mass. (PRWEB) , ... July 09, 2020 ... ... novel approaches to cell therapy, today announced the hiring of Allen R. Nissenson, ... executive team and oversee the clinical development of Sentien’s lead product, SBI-101. ...
Breaking Biology Technology:
Cached News: