Molecular Mechanochemistry: An Emerging Discipline At The Nexus Of Biology A...( ltransduction pathway to another in...)

l transduction pathway to another, involving gene expression and protein transcription in the affected endothelial cells. Davies' lab is studying several endothelial-cell genes sensitive to blood flow and how the molecular pathways that govern them vary due to changing external forces.

Getting at the heart of blood-flow dynamics is also critical to understanding the localization of atherosclerotic lesions. "Eddies form at arterial branches--much like when a river branches--and that's where arterial lesions develop, leading to heart attack and stroke," explains Davies. His research team has exposed endothelial cells in culture to fluid conditions much like vessel-branch vortices to better understand how cells respond to these circumstances. The aim of these investigations is to develop interventional drugs, gene-therapies, and better blood-clot-dissolving enzymes for diseased vessels.

Editor's Note: Dr. Davies can be reached at 215-898-4647 or pfd@pobox.upenn.edu The University of Pennsylvania Medical Center's sponsored research and training ranks third in the United States based on grant support from the National Institutes of Health, the primary funder of biomedical research and training in the nation--$175 million in federal fiscal year 1997. In addition, for the third consecutive year, the institution posted the highest annual growth in these areas--17.6 percent--of the top ten U.S. academic medical centers. News releases from the University of Pennsylvania Medical Center are available to reporters by direct e-mail, fax, or U.S. mail, upon request. They are also posted electronically to the medical center website (http://www.m ed.upenn.edu), to EurekAlert! (http://www.eurekalert.org), sponsored by the American Association for the Advancement of Science.

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Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
18-Feb-1998

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