HOME >> BIOLOGY >> NEWS
Molecular Mission Unveils New Genetic Link To Common Birth Defect

Cutting and pasting enormous chunks of DNA into the chromosomes of mice, scientists have uncovered at least one genetic cause for a spectrum of urinary tract disorders, the most common survivable congenital defects in humans. The finding, published in the November 16 issue of EMBO Journal, links a previously studied gene, called GATA-2, with ensuring the proper development of the genitourinary tract. From earlier work, scientists already knew that GATA-2 is critical for the formation of blood.

The discovery paves the way for researchers to identify diagnostic and/or treatment strategies to combat a variety of bladder and kidney disorders in newborns, most notably a condition called hydroureteronephrosis, a physiological plumbing problem in which urine cannot make its way to the bladder because of an anatomical defect in the tubes (ureters) that connect the kidney to the bladder.

"This is a great example of how a basic research project can serendipitously lead to a better understanding of the cause of a common human birth defect," said Dr. Judith Greenberg, director of the Division of Genetics and Developmental Biology at the National Institute of General Medical Sciences, which provided funding for the study.

Despite its unfamiliar-sounding name, hydroureteronephrosis is a prevalent malady. One in 200 babies has the disorder, which is usually diagnosed by prenatal ultrasound screening and in many cases can be surgically repaired. Nevertheless, scientists don't understand the underlying cause of the problem.

But while the disease-related implications of the finding may be readily apparent, Dr. Douglas Engel of Northwestern University, who led the study, is excited about the more general, but profound, impact his team's discovery will have on the larger task of ascribing genes to functions in the developing mouse--and almost certainly human--embryo.

Until now, no one would have suspected that the GATA-2 protein did anything besides helping the dev
'"/>

Contact: Alison Davis
davisa@nigms.nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
16-Nov-1998


Page: 1 2 3 4

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... LLC , a medical device company focused on improving the safety ... ISO 13485 Certification, the global standard for medical device quality management ... ... for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it validates our ...
(Date:6/23/2017)... and ITHACA, N.Y. , June 23, ... University, a leader in dairy research, today announced a ... to help reduce the chances that the global milk ... of this dairy project, Cornell University has become the ... the Food Supply Chain, a food safety initiative that ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... wash is a basic first aid supply for any work environment, but most personal eye ... first if a dangerous substance enters both eyes? It’s one less decision, and likely quicker ... eye piece. , “Whether its dirt and debris, or an acid or alkali, getting anything ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased ... of over 5.5 million people each year. Especially those living in larger cities are ... - based in one of the most pollution-affected countries globally - decided to take ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the ... won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to ... Experience from US2020. , US2020’s mission is to change the trajectory of STEM ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon ... awards honoring scientists who have made outstanding contributions to analytical chemistry ... Pittcon 2018, the world’s leading conference and exposition for laboratory science, which will ...
Breaking Biology Technology:
Cached News: