HOME >> BIOLOGY >> NEWS
Molecular clue to Alzheimer's mystery found

In cell biology studies, researchers report "strong evidence" that a molecule called ubiquilin controls levels of certain proteins that are central to the early development of Alzheimer's disease.

In today's Journal of Cell Biology, researchers of the University of Maryland Biotechnology Institute (UMBI) say the discovery may provide an important way to control the activity of proteins called presenilins. Previous studies showed that mutations in genes coding for presenilins cause early onset of Alzheimer's disease.

Mervyn Monteiro, research professor with UMBI's Medical Biotechnology Institute and coworkers at Case Western Reserve University, also found ubiquilin to be "highly expressed" in neurons of human brain and associated with tangles and plaques in neurons of brains that are afflicted with Alzheimer's and Parkinson's diseases, respectively.

"Ubiquilin is the first molecule, to our knowledge, that has been found to increase presenilin levels in cells," said Monteiro. "Now, we want to see how ubiquilin regulates presenilin proteins carrying Alzheimer's disease mutations. This is an important step in understanding presenilins and may lead to eventual treatments or cures for the neuropathological diseases."

Molecular genetic studies previously linked early-onset Alzheimer's disease to mutations in three genes: amyloid precursor protein, presenilin-1 and presenilin-2. However, the biological reasons why mutations in the genes cause Alzheimer's disease has not yet been fully resolved, said Monteiro. To find the latest clues, the researchers used combinations of immunological and DNA-taging methods to learn that ubiquilin is localized in both the nucleus and cytoplasm in cells.

The journal paper further explains that "modulation of presenilin levels by ubiquilin" may have important consequences to many cellular functions, because presenilins have been linked to various biological processes, including calcium regulation, apoptosis (pr
'"/>

Contact: Steve Berberich
berberic@umbi.umd.edu
410-385-6315
University of Maryland Biotechnology Institute
12-Nov-2000


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: