HOME >> BIOLOGY >> NEWS
Molecular marker predicts success of breast cancer treatment

A new study demonstrates that the ratio of the expression levels of two genes can be used to accurately predict the clinical outcome of tamoxifen treatment for early stage breast cancer. It is the first method to reliably differentiate between patients who experienced disease-free survival and those at risk for tumor recurrence. The findings also provide new insight into the molecular mechanisms that may contribute to tamoxifen resistance.

Tamoxifen is one of the most widely used therapies for breast cancer. It works by blocking the action of estrogen on breast cancer cells. Estrogen directs the growth of normal breast cells, but can also stimulate the abnormal and unregulated cell growth associated with breast cancer. Unfortunately, nearly 40% of breast cancer patients fail to respond to tamoxifen or eventually become resistant to treatment, and there is no reliable way to predict treatment outcome. Dr. Dennis C. Sgroi from the Pathology Department at Massachusetts General Hospital and Dr. Mark G. Erlander from Arcturus Bioscience, Inc. in Mountain View, California examined the gene expression levels in 60 breast cancers from patients who were treated with tamoxifen after their surgery. Measuring gene expression is a way to examine whether or not a gene is functioning. They discovered that the ratio of the expression levels of two genes, HOXB13 and IL17BR, accurately predicted whether tumors reoccurred after treatment with tamoxifen. The researchers also found that when HOXB13 levels were experimentally elevated in cells from normal breast tissue cultured in the laboratory, the cells showed obvious morphological changes and became more invasive in response to growth signals. "This suggests that HOXB13 may directly contribute to tumor invasion and metastasis," explains Dr. Sgroi.

The researchers conclude that the HOXB13:IL17BR expression ratio may provide an effective molecular marker for identifying breast cancer patients who will be less likely to
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
3-Jun-2004


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/12/2018)... ... September 12, 2018 , ... Captiva ... announced today it has received 510(k) clearance from the U.S. Food and Drug ... MIS Pedicle Screw System. , TowerLOX-EXT MIS Extended Tab Pedicle Screws provide the ...
(Date:9/1/2018)... ... ... this minute, Frenchman Ben Lecomte is hard at work on his second ocean crossing. After ... new challenge: going from Tokyo to San Francisco, churning his limbs eight hours a day ... As the first expedition of its kind, The Swim is far more than just an ...
(Date:8/31/2018)... Wash., and CARDIFF, Wales (PRWEB) , ... August ... ... Space Agency. Martha Sanchez, senior scientist, IBM Research. Jacklyn Novak, infrared materials engineer, ... of Katherine Johnson, the NASA mathematician who just celebrated her 100th birthday. Today, ...
Breaking Biology News(10 mins):
(Date:8/17/2018)... ... August 16, 2018 , ... The opening of the new Titusville facility ... Services in 2016. Chemko had a well established local presence, servicing the Space Coast ... projects such as the ongoing work at the Mobile Launch Platform (MLP) in support ...
(Date:8/17/2018)... ... August 16, 2018 , ... Ambry Genetics ... the AmbryShare project were published today in JAMA Oncology, identifying new and confirming ... ever conducted. , Every year hereditary breast cancer affects more than 20,000 women ...
(Date:8/14/2018)... , ... August 13, 2018 , ... ... chemical fume hoods and biological safety cabinets. In addition, Labconco produces other lab ... one measure of its commitment to quality and consistency in design and manufacturing. ...
(Date:8/14/2018)... ... 14, 2018 , ... The growing interest in PEEK-OPTIMA™ spinal ... Association of Orthopaedic Surgeons (CAOS) held in partnership with the North American Spine ... and Invibio Biomaterial Solutions partnered to demonstrate the new Uplifter® Expandable ...
Breaking Biology Technology:
Cached News: