HOME >> BIOLOGY >> NEWS
Molecular motor implicated in tissue remodeling

St. Louis, Sept. 30, 2004--A well-known enzyme present in the skin and other tissues turns out to be a molecule-sized motor that extracts its fuel from the road it runs on, according to researchers at Washington University School of Medicine in St. Louis. Their discovery appears in the Oct. 1 issue of Science.

The enzyme, MMP-1, is a member of a group of enzymes that breaks down collagen, a fibrous substance that constitutes the foundation of the extracellular matrix that supports the cells in the body's tissues.

"By digesting collagen, enzymes such as MMP-1 initiate tissue remodeling, which can have a variety of purposes from organ development to tissue repair to metastatic invasion of tumors," says senior author Gregory Goldberg, Ph.D., professor of dermatology and of biochemistry and molecular biophysics. "Because they participate in all basic tissue metabolism, we want to understand how they function."

Goldberg and his colleagues Savees Saffarian, Ivan Collier, Barry Marmer and Elliot Elson found that MMP-1 operates as a molecular motor--a molecule that converts chemical energy into motion. "This is the only extracellular motor known," says Elson, Ph.D., coauthor and professor of biochemistry and molecular biophysics.

The research team discovered that MMP-1 moves along a collagen filament with a net unidirectional motion. One-way motion indicates that energy is being utilized, so the team looked for an energy source.

While most molecules that act as motors are inside cells and get their energy from a ubiquitous high-energy molecule called ATP, the team found that MMP-1 gets its energy by breaking the molecular bonds in the collagen filament it is attached to.

"In fact," Goldberg says, "with our model, a whole new principle emerges in which molecular motors in the extracellular matrix operate by extracting energy from the very track they move upon."

The researchers propose that the molecular motor contrib
'"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
30-Sep-2004


Page: 1 2

Related biology news :

1. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
2. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
3. Molecular staples shape a cancer killer
4. Molecular motor myosin VI moves hand over hand, researchers say
5. Molecular therapeutics advance fight against brain cancer
6. Molecular motor shuttles key protein in response to light
7. Molecular traffic cop directs cellular signals
8. Molecular marker predicts success of breast cancer treatment
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... ... the appointment of Susan Murphy as the new President of Molecular Devices, replacing ... Molecular Devices’ parent company, Danaher Corporation. , Since joining Molecular Devices in a ...
(Date:6/4/2019)... ... 2019 , ... Lajollacooks4u is delighted to announce it has been named as ... is given only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, ... , To qualify for the Certificate of Excellence –- an award that only 10 ...
(Date:5/31/2019)... INDIANAPOLIS (PRWEB) , ... May 29, 2019 , ... ... and configurations on Mac, Windows and mobile, announces the launch of version 13.1. ... via the latest Android Management API, and supports Apple’s spring release functionality. Version ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... DES MOINES, Iowa (PRWEB) , ... July 08, 2019 , ... ... in Des Moines, Iowa, the National Corn Growers Association (NCGA) announced the ... unique technology to improve a product or process using field corn to produce biobased ...
(Date:7/2/2019)... ... ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , was recently featured in ... on regenerative veterinary medicine as a means of improving the quality of life for ... Brentwood and Pacific Palisades International Film Festival in Los Angeles, California where it received ...
(Date:6/18/2019)... , ... June 17, 2019 , ... ... they have entered into an agreement for production and manufacturing of GMP-grade adeno-associated ... treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment ...
(Date:6/12/2019)... ... June 12, 2019 , ... ... leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries, ... been signed. The agreement will grant exclusive rights for Zillion to represent LDA ...
Breaking Biology Technology:
Cached News: