HOME >> BIOLOGY >> NEWS
Molecular motor myosin VI moves 'hand over hand,' researchers say

CHAMPAIGN, Ill. -- In the human body, hundreds of different types of biomolecular motors help carry out such essential tasks as muscle contraction, moving chromosomes during cell division, and reloading nerve cells so they can repeatedly fire.

How these little proteins perform their duties is becoming clearer to scientists using an extremely sensitive measurement technique. Myosin VI, they found, moves by the same "hand-over-hand" mechanism as two other molecular motors, myosin V and kinesin.

"Now that a third molecular motor has been found to move in the same hand-over-hand fashion, the argument for a rival 'inchworm' motion is getting pretty weak," said Paul Selvin, a professor of physics at the University of Illinois at Urbana-Champaign and a co-author of a paper to appear in the Journal of Biological Chemistry.

Myosin VI is a reverse-direction molecular motor that moves materials to various locations within a living cell. Like the related protein myosin V, myosin VI has two "arms" connected to a "body." The tiny molecule converts chemical energy into mechanical motion, and transports its load by "stepping" along polarized filaments of actin -- but in the opposite direction from other myosin variants.

"Studies have suggested two main models for the stepping movement," Selvin said. "One is the hand-over-hand model in which the two arms alternate in the lead. The other model is the inchworm model in which one arm always leads."

To examine the myosin VI stepping mechanism, the researchers applied the same technique that was used to study both myosin V and kinesin. Called FIONA -- Fluorescence Imaging with One Nanometer Accuracy -- the measurement technique can track the position of a single molecule to within 1.5 nanometers. (One nanometer is a billionth of a meter, or about 10,000 times smaller than the width of a human hair).

"First, we attached a small fluorescent dye to one of the arms and took a picture wit
'"/>

Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
31-Aug-2004


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular therapeutics advance fight against brain cancer
6. Molecular motor shuttles key protein in response to light
7. Molecular traffic cop directs cellular signals
8. Molecular marker predicts success of breast cancer treatment
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2019)... ... January 03, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... http://www.xtalks.com to check out our upcoming webinars, or click below to learn ...
(Date:12/20/2018)... ... December 20, 2018 , ... Human ... the completion of a new usability/observation room. This addition will help meet the ... devices and drug delivery devices/combination products are safe and easy to use when ...
(Date:12/18/2018)... ... December 18, 2018 , ... ... cancers and other serious diseases, today announced the publication of an early feasibility ... treatment of rGBM. , The publication of the study, An Early Feasibility ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... ... December 11, 2018 , ... Researchers at Worcester ... to quickly detect Clostridium difficile (C. diff), a dangerous and sometimes fatal gastrointestinal ... that can be used onsite in doctor’s offices and nursing homes, providing results ...
(Date:12/13/2018)... ... December 13, 2018 , ... ... includes food (human) ingredient. This has been part of their strategic plan and ... Plan and certification creates custom fermentation opportunities for MDG within the $44 Billion ...
(Date:12/5/2018)... ... December 05, 2018 , ... The incredible life story of former ... the European Parliament by Carlos Moedas, the European Commissioner for Research and Innovation. ... in Our Daily Lives, Commissioner Moedas spoke at length of Yousef’s life and journey, ...
(Date:11/29/2018)... Utah (PRWEB) , ... November 29, 2018 , ... RAGS, ... was led by Kickstart Seed Fund, with participation from existing investor and board member ... and Davis Smith of Cotopaxi. The additional funding will enable the company to accelerate ...
Breaking Biology Technology:
Cached News: