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Molecular motor myosin VI moves 'hand over hand,' researchers say

h a digital camera attached to a microscope to find exactly where the dye was," Selvin said. "Then we fed the myosin a little food called adenosine triphosphate, and it took a step. We took another picture, located the dye, and measured how far the dye moved."

By examining the step size, the scientists could determine whether the protein used a hand-over-hand mechanism or an inchworm mechanism for movement. "The average step size for the myosin VI arm was approximately 60 nanometers, while the molecule's center of mass moved only half that distance," Selvin said. "This clearly indicated that a hand-over-hand model was being employed."

Surprisingly, myosin VI has a step size that is highly variable, but on average is nearly as large as that of myosin V, which has a lever arm that is three times longer.

"For myosin VI to reach the same distance, the molecule must somehow come apart and then snap together again," Selvin said. "To understand how it accomplishes this feat will require further study."

The co-authors of the paper are Selvin, Hyokeun Park and Ahmet Yildiz at Illinois, and Li-Qiong Chen, Dan Safer, H. Lee Sweeney and Zhaohui Yang at the University of Pennsylvania.


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Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
31-Aug-2004


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