HOME >> BIOLOGY >> NEWS
Molecular motor shuttles key protein in response to light

In experiments with fruit flies, Johns Hopkins researchers have discovered how a key light-detecting molecule in the eye moves in response to changes in light intensity.

Their finding adds to growing evidence that some creatures -- and probably people -- adapt to light not only by mechanically shrinking the pupil to physically limit how much light enters the eye, but also by a chemical response.

Building on their previous work showing that specific proteins in eye cells are redistributed in response to bright light, the Johns Hopkins team now reports how a key protein called arrestin is shuttled from a "holding area" where it binds and calms a light-detecting protein. Writing in the July 7 issue of Neuron, the team says arrestin is moved around by a tiny molecular motor, called myosin, which travels along the "train tracks" of the cell's internal skeleton.

Arrestin's swift relocation, the researchers proposed, helps prevent temporary blindness that would otherwise be caused by a sudden increase in light intensity, such as occurs when stepping from a dark movie theater into the bright afternoon sunshine.

"We knew that arrestin was transported, but we didn't know how this occurred," says Craig Montell, Ph.D., professor of biological chemistry. "Fly and mammalian eyes have similar light detector cells and proteins, and it takes about the same amount of time for our eyes to adapt to light, so we suspect that comparable mechanisms exist in humans."

The light-detecting cells in fruit flies are similar to the rod and cone cells found in the human retina. One end of each cell contains the protein that directly responds to light, but other proteins critical for the light response are shifted back and forth into different parts of the cell in a light-dependent manner. Scientists didn't know how these molecules might be moved from one end of the cell to the other, until now.

Postdoctoral fellow Seung-Jae Lee, Ph.D., had a hunch
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
16-Jul-2004


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular traffic cop directs cellular signals
8. Molecular marker predicts success of breast cancer treatment
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC , ... that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) ... with severe COVID-19. This is the first study of an XPO1 inhibitor in ...
(Date:6/23/2020)... ... June 22, 2020 , ... The field of quantitation of large molecules ... have dominated this area. However, the use of mass spectrometry in this field has ... the question “How do you choose which approach to use (LBA or MS)?” ...
(Date:6/19/2020)... ... June 16, 2020 , ... The director of stem cell biotechnology ... the stem cell medicine and pharmaceutical industries have easier access to stem cell counting, ... July 5 of this year, Independence Day weekend in the U.S., Asymmetrex is offering ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... HOUSTON (PRWEB) , ... August ... ... a biopharmaceutical cold chain validation engineering firm, is making available for ... driving the need to incorporate concurrent transport simulation testing into today’s biologics ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... Jim Corrigan, President and CEO has been named one of the 100 most ... industry sectors, PharmaVoice 100 honorees are selected based on how they have inspired ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption of ... and around the globe, requiring fast track capacity to provide patients with urgently ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing solutions ... that they have entered into a strategic partnership whereby Catalent will provide support ...
Breaking Biology Technology:
Cached News: