HOME >> BIOLOGY >> NEWS
Molecular muscle motor found to move backwards

Long filaments of a protein known as actin run through every cell in the body, serving as a kind of railroad along which another protein called myosin transports vital materials to locations throughout the cell. Until now, scientists believed that the fifteen known variants of myosin all moved in only one direction on the actin filaments, towards the plus end of the polarized filaments. If a cell needed materials carried in two directions, it simply provided parallel actin filaments running in both directions - but the myosin itself could only go forward along the actin.

Now, in a finding likely to surprise many cell biologists, University of Pennsylvania Medical Center scientists have discovered that one of the myosin variants - myosin VI - moves backwards on actin, toward the minus end of the filaments. A report on the new study appears in the September 30 issue of Nature and is featured on the cover.

The observation suggests how, in the relatively few structures in the body in which the actin filaments are known to run in only one direction - notably the inner-ear projections responsible for sensing sound - the cells are able to assemble and maintain themselves. In fact, mice in whom myosin VI is defective are deaf, suggesting the critical importance of the variant motor protein to the so-called hair cells of the inner ear upon which hearing depends. Myosin VI may be similarly crucial in other parts of the body where actin filaments are aligned in only one direction.

"In many ways, the myosin protein moving along an actin filament is like a sure-footed gymnast able to walk only one direction on a balance beam," says H. Lee Sweeney, PhD, chairman of the department of physiology and senior author on the study. "What we've shown here is that, surprisingly, one form of myosin is able to walk backwards on the beam."

Sweeney and his team began their efforts to identify myosin VI's unique capabilities by assumi
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
30-Sep-1999


Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2019)... , ... April 17, 2019 , ... ... biostatistics, and other services to clinical trial sponsors, has entered into a multi-year ... agreement will enable Quartesian, a member of Medrio’s Certified Partner Program, to leverage ...
(Date:4/16/2019)... Tenn. (PRWEB) , ... April 16, 2019 , ... ... tissue markets, celebrated the grand opening of its new medical device facility on ... 2005. , Located in Memphis, TN the new facility includes 108,500 square feet ...
(Date:4/16/2019)... NEW YORK (PRWEB) , ... April 16, 2019 ... ... the Top 50 Healthcare Technology CEOs of 2019 . An extensive process ... the fields of medical devices, biotech, healthcare analytics, healthcare software and other related ...
Breaking Biology News(10 mins):
(Date:3/27/2019)... , ... March 27, 2019 , ... In honor of ... awareness on the importance of healthy meals and good nutrition. This month, Chef ... Food Bank’s volunteer chef. , The first segment addressed the nutritional value ...
(Date:3/23/2019)... ... March 22, 2019 , ... ... LenS3 Multi-Angle Light Scattering (MALS) detector , offering a revolutionary approach for the ... polysaccharides, proteins, and biopolymers. A novel optical design, a unique cell-block assembly, and ...
(Date:3/19/2019)... ... ... Bogey was nine years old when he injured both of his cruciate ligaments. On ... Bogey to experience problems with his mobility. According to his owners, he could barely ... the couch. , His owners, devastated at the sight of Bogey in so much pain ...
(Date:3/19/2019)... , ... March 19, 2019 ... ... HaShomer, the largest hospital in Israel and the Middle East region, and ... the state-of-the-art Cocoon™ manufacturing platform. The partnership will enable Sheba to vastly ...
Breaking Biology Technology:
Cached News: