HOME >> BIOLOGY >> NEWS
Molecular staples shape a cancer killer

Howard Hughes Medical Institute (HHMI) researchers have successfully designed and improved a new type of cancer-killing compound by performing molecular surgery to stabilize the molecule so that it selectively triggers cell death.

The idea for developing the compound emerged from the HHMI laboratory of Stanley J. Korsmeyer, who leads one of the hottest research teams currently studying programmed cell death, or apoptosis, a genetic program that executes cells that are no longer needed. Using the biologically active portion of a protein that triggers apoptosis, Korsmeyer's team successfully inserted non-natural amino acids into the peptide sequence and then performed a chemical reaction that created a "staple" within the molecule, resulting in its stabilization. Korsmeyer and the paper's lead author, Loren D. Walensky, who are at the Dana-Farber Cancer Institute at Harvard Medical School, reported their studies in the September 3, 2004, issue of the journal Science.

The chemical approach they applied, called hydrocarbon stapling, was developed by their collaborator Gregory L. Verdine of Harvard University, and permitted the researchers to overcome the tendency of short peptides to lose their critical three-dimensional structure and their ability to kill cells -- when removed from the context of the complete protein. This has been one of the greatest obstacles associated with using short peptides as therapeutic agents, and has hindered their legitimacy as pharmaceutical lead compounds. By making the peptides more resistant to degradation and enabling their cellular uptake, the hydrocarbon staple overcomes classic shortcomings of peptide therapeutics.

As the molecular events that lead to execution and death have become clearer during the last decade, researchers speculated that it would not be long before biotechnology and pharmaceutical companies were racing to develop novel compounds that could be used to hasten or prevent the demise of c
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
2-Sep-2004


Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular motor myosin VI moves hand over hand, researchers say
5. Molecular therapeutics advance fight against brain cancer
6. Molecular motor shuttles key protein in response to light
7. Molecular traffic cop directs cellular signals
8. Molecular marker predicts success of breast cancer treatment
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... ... July 09, 2019 , ... Murrieta Genomics, a ... incubator program. The founder and CEO of Tx Genetic, Helen Harrison, has spent ... suffering from epithelial connective tissue disorders. , “We are pleased and excited to ...
(Date:6/25/2019)... ... June 25, 2019 , ... ActX ... raw data, easily available from 23andMe, customers can get access to professionally reviewed ... available for both 23andMe Ancestry and Health + Ancestry customers., With the ActX ...
(Date:6/16/2019)... ... June 14, 2019 , ... Respected periodontist, Dr. ... fifth annual Neodent World Congress. Attended by thousands of dental clinicians from all ... in the world of dentistry. The three-day event featured a team of expert ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... City, California (PRWEB) , ... ... ... allowance of our patent applications from the USPTO providing proprietary interest to ... AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights ...
(Date:5/22/2019)... ... May 22, 2019 , ... Artemis (formerly Agrilyst), the leading ... A funding round co-led by Astanor Ventures and Talis Capital ... and iSelect Fund . The company has raised $11.75m to date and will ...
(Date:5/14/2019)... TOWNSHIP, N.J. (PRWEB) , ... May 13, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... new Heliumleak.com company website. The redesigned website aims to improve LDA’s ability to ...
(Date:5/4/2019)... SÃO PAULO, Brazil (PRWEB) , ... May 03, ... ... the lecture given by the President of the Dakila Pesquisas Association, the scientist ... of the Councilmen 2019, in Brasília (DF). Urandir detailed the results of some ...
Breaking Biology Technology:
Cached News: