HOME >> BIOLOGY >> NEWS
Molecular staples shape a cancer killer

Howard Hughes Medical Institute (HHMI) researchers have successfully designed and improved a new type of cancer-killing compound by performing molecular surgery to stabilize the molecule so that it selectively triggers cell death.

The idea for developing the compound emerged from the HHMI laboratory of Stanley J. Korsmeyer, who leads one of the hottest research teams currently studying programmed cell death, or apoptosis, a genetic program that executes cells that are no longer needed. Using the biologically active portion of a protein that triggers apoptosis, Korsmeyer's team successfully inserted non-natural amino acids into the peptide sequence and then performed a chemical reaction that created a "staple" within the molecule, resulting in its stabilization. Korsmeyer and the paper's lead author, Loren D. Walensky, who are at the Dana-Farber Cancer Institute at Harvard Medical School, reported their studies in the September 3, 2004, issue of the journal Science.

The chemical approach they applied, called hydrocarbon stapling, was developed by their collaborator Gregory L. Verdine of Harvard University, and permitted the researchers to overcome the tendency of short peptides to lose their critical three-dimensional structure and their ability to kill cells -- when removed from the context of the complete protein. This has been one of the greatest obstacles associated with using short peptides as therapeutic agents, and has hindered their legitimacy as pharmaceutical lead compounds. By making the peptides more resistant to degradation and enabling their cellular uptake, the hydrocarbon staple overcomes classic shortcomings of peptide therapeutics.

As the molecular events that lead to execution and death have become clearer during the last decade, researchers speculated that it would not be long before biotechnology and pharmaceutical companies were racing to develop novel compounds that could be used to hasten or prevent the demise of c
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
2-Sep-2004


Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular motor myosin VI moves hand over hand, researchers say
5. Molecular therapeutics advance fight against brain cancer
6. Molecular motor shuttles key protein in response to light
7. Molecular traffic cop directs cellular signals
8. Molecular marker predicts success of breast cancer treatment
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2020)... ... , ... Toronto-based clinical research organization (CRO) and regulatory consulting firm, dicentra ... minutes south of Clarksburg on a farm on Beaver Valley Road. , The owners ... Orchard, and decided it would be a great new option for employees to relocate ...
(Date:3/2/2020)... SPRING, Md. (PRWEB) , ... March 02, 2020 , ... ... a globally-recognized program co-founded by the Security Industry Association (SIA) and ... the SIA Women in Security Forum . The recipients of this year’s Women ...
(Date:2/28/2020)... ... , ... Meridian Clinical Research , a leading investigative research network, is ... Best Clinical Trial Site. Meridian is also the largest member of Platinum Research ... nominations were the result of two voting rounds, and winners will be announced at ...
Breaking Biology News(10 mins):
(Date:3/3/2020)... ... March 03, 2020 , ... Ideal Implant Incorporated Founder and ... technology at the IMCAS Innovation Shark Tank 2020 in Paris, France in January. ... and aesthetic science industries that promise to revolutionize medical practices in their fields. ...
(Date:2/21/2020)... ... February 20, 2020 , ... ... capability to perform complex, efficient and elegant chemistry. Humans have been increasingly ... our own goals. , Through rapidly evolving technologies and strategies for modern ...
(Date:2/19/2020)... ... February 18, 2020 , ... Intech , the ... a new and unified global brand identity, as it celebrates its 20th anniversary. ... as well as an enthusiasm for designing and manufacturing state-of-the-art medical devices, Intech ...
(Date:2/10/2020)... ... , ... R3 Medical Training announced it is now registering for its next ... course is hands on involving real patients and stem cell biologics, with every attendee ... Cell Training Course has received rave reviews from attendees, who love the hands on ...
Breaking Biology Technology:
Cached News: