HOME >> BIOLOGY >> NEWS
Molecular staples shape a cancer killer

Howard Hughes Medical Institute (HHMI) researchers have successfully designed and improved a new type of cancer-killing compound by performing molecular surgery to stabilize the molecule so that it selectively triggers cell death.

The idea for developing the compound emerged from the HHMI laboratory of Stanley J. Korsmeyer, who leads one of the hottest research teams currently studying programmed cell death, or apoptosis, a genetic program that executes cells that are no longer needed. Using the biologically active portion of a protein that triggers apoptosis, Korsmeyer's team successfully inserted non-natural amino acids into the peptide sequence and then performed a chemical reaction that created a "staple" within the molecule, resulting in its stabilization. Korsmeyer and the paper's lead author, Loren D. Walensky, who are at the Dana-Farber Cancer Institute at Harvard Medical School, reported their studies in the September 3, 2004, issue of the journal Science.

The chemical approach they applied, called hydrocarbon stapling, was developed by their collaborator Gregory L. Verdine of Harvard University, and permitted the researchers to overcome the tendency of short peptides to lose their critical three-dimensional structure and their ability to kill cells -- when removed from the context of the complete protein. This has been one of the greatest obstacles associated with using short peptides as therapeutic agents, and has hindered their legitimacy as pharmaceutical lead compounds. By making the peptides more resistant to degradation and enabling their cellular uptake, the hydrocarbon staple overcomes classic shortcomings of peptide therapeutics.

As the molecular events that lead to execution and death have become clearer during the last decade, researchers speculated that it would not be long before biotechnology and pharmaceutical companies were racing to develop novel compounds that could be used to hasten or prevent the demise of c
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
2-Sep-2004


Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular motor myosin VI moves hand over hand, researchers say
5. Molecular therapeutics advance fight against brain cancer
6. Molecular motor shuttles key protein in response to light
7. Molecular traffic cop directs cellular signals
8. Molecular marker predicts success of breast cancer treatment
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/2/2018)... ... August 02, 2018 , ... RxS LLC ... biotech companies, today announced that Mark Jara, principal of the organization, has been ... life sciences industry. Individuals named to PharmaVOICE 100 are leaders who drive the ...
(Date:8/1/2018)... ... August 01, 2018 , ... RURO, Inc., ... Limfinity® version 7.1. Limfinity® is the software framework that all of RURO’s products ... for both current users and the future of RURO’s laboratory software portfolio. , ...
(Date:8/1/2018)... ... August 01, 2018 , ... Clinical Training ... MA's and Administrative staff. , This full day course is an interactive day ... will expose your staff to regenerative medicine procedures and processing techniques, and facility ...
Breaking Biology News(10 mins):
(Date:8/7/2018)... , ... August 06, 2018 , ... ... and diagnostics companies, announces the placement of Dr. Paul Harney as President, North ... North America growth strategy and enhancing client satisfaction. He was also named to ...
(Date:7/31/2018)... ... July 31, 2018 , ... Leading regenerative veterinary medicine ... extracting and using adipose tissue-derived stem cells to treat or prevent inflammation at ... patent covers Canada specifically, VetStem has been issued similar patents that cover the ...
(Date:7/27/2018)... ... July 27, 2018 , ... ... Group (BRAG®) and representatives of the Biotechnology Innovation Organization (BIO) met with ... white paper, “Proposal for a Toxic Substances Control Act (TSCA) Inventory Representation ...
(Date:7/25/2018)... GENEVA, Wis. (PRWEB) , ... July 25, 2018 ... ... impact of a biofield energy treated proprietary nutraceutical to combat inflammation and autoimmune ... as well as, immune function response. The following data was reported:, ...
Breaking Biology Technology:
Cached News: