HOME >> BIOLOGY >> NEWS
Molecular 'stop signs' may hold secret of nerve regeneration

Using brain cells from rats, scientists at The Johns Hopkins University School of Medicine and the University of Hamburg have manipulated a molecular "stop sign" so that the injured nerve cells regenerate.

While their findings are far from application in people, the prospects for eventually being able to repair spinal cord injury are brighter, they say.

"Four thousand years ago, physicians wrote that spinal cord injury was untreatable, and unfortunately it's much the same today," says Ronald L. Schnaar, Ph.D., professor of pharmacology and of neuroscience at Hopkins. "But the basic-science framework for improving this situation is quickly emerging."

In adult mammals, including humans, molecular signals carefully control the number of contacts nerve cells make by inhibiting new connections. When the brain or spinal cord has been damaged, the goal is to neutralize those inhibitors so that the long tentacles of nerve cells, the axons, might reestablish their broken connections, says Schnaar.

The research team reports identifying brain chemicals that are involved in the ability of one of the inhibitors to prevent injured nerve cells from connecting to other nerves or muscles. By keeping the chemicals from interacting with the inhibitor, the researchers were able to stimulate damaged nerve cells to regenerate in laboratory dishes. Their report is in the June 11 issue of the Proceedings of the National Academy of Sciences.

"In the central nervous system, once an axon is interrupted in some way, through disease or injury, generally it's stopped dead in its tracks, but in the rest of the body, damaged axons can re-grow," says Schnaar. "To make headway in treating brain and spinal cord injury, we need to attack this problem from a number of angles, and our studies have provided an additional target for intervention."

Of the "stop signs" identified so far, Schnaar's team focused on MAG, or myelin-associated glycoprotein, whi
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
18-Jun-2002


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)...  The general public,s help is being enlisted in what,s thought to ... and on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest ... the gut. The project's goal is to help advance scientific knowledge of ... ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
(Date:10/9/2017)... ... 2017 , ... At its national board meeting in North Carolina, ARCS® ... Departments of Physics and Astronomy, has been selected for membership in ARCS Alumni ... the 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion ...
(Date:10/9/2017)... (PRWEB) , ... October 09, ... ... published on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s ... the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. ... to perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s ...
Breaking Biology Technology:
Cached News: