HOME >> BIOLOGY >> NEWS
Molecular therapeutics advance fight against brain cancer

(Philadelphia, PA) -- An estimated 41,000 new cases of primary brain tumors are expected to be diagnosed in 2004, according to the American Brain Tumor Association. To further narrow the gap between diagnosis and effective therapy, physicians at the University of Pennsylvania Health System now offer several promising approaches to brain tumor treatment, including novel imaging for oncologic neurosurgery and refined genetic testing for tumors to better target treatment.

Through enhanced magnetic resonance imaging (MRI), newer and broader information is helping to better guide tumor removal. MRI is used to measure the anatomy and metabolism of tumors. This informs surgeons pre- and post-operatively with a three-dimensional map of tumor-associated blood flow to more precisely assess the full extent of tumor growth versus conventional imaging methods. "This novel approach helps guide surgery and assessment of treatment response," says Donald M. O'Rourke, M.D., Associate Professor of Neurosurgery. These novel imaging methods are leading to increased patient survival by allowing for greater tumor removal in a safe manner.

Neuroscientists are also ushering in a new era in which genetics will dictate treatment. In the 1990s researchers noted that a more favorable prognosis in patients with certain brain tumors, primarily oligodendrogliomas, was associated with a deletion of genes on chromosomes 1 and 19. This genetic loss translates into a significant life-expectancy gain for some patients and is therefore a robust predictor that post-surgery chemotherapy should be given to such patients.

Patients with the genetic deletion on chromosome 1 have a median survival in certain cases of about 10 years and respond particularly well to chemotherapy given immediately after surgery. Patients with the deletion have slower-growing tumors and show a better response to chemotherapy; whereas, those without the deletion have relatively faster-growing tumors and are
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
4-Aug-2004


Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular motor shuttles key protein in response to light
7. Molecular traffic cop directs cellular signals
8. Molecular marker predicts success of breast cancer treatment
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2019)... ... 18, 2019 , ... Early engagement not only improves and ... improves participation by better balancing scientific objectives with patient goals. , Reaching out ... entire process from development to market. Involving these groups in this manner ensures ...
(Date:3/14/2019)... ... ... Highmark Health’s VITAL Innovation Platform has been named the winner in the “Corporate Innovation” ... top honors in the awards. Winners were announced at an event on March 12 ... May 10 that also raises funds for Carnegie Science Center programs that inspire young ...
(Date:3/12/2019)... ... March 12, 2019 , ... FEITIAN Technologies ... all-in-one smart cards, announced today the launch of two new payment card types ... Dynamic CVV Payment cards. These advanced technologies will help all elements of the ...
Breaking Biology News(10 mins):
(Date:3/12/2019)... LIÈGE, Belgium (PRWEB) , ... March 12, 2019 ... ... for sample preparation and epigenetics research, has launched its third generation long-fragment DNA ... the second generation instrument with a user-friendly interface, automated processing, and the ...
(Date:3/5/2019)... ... 2019 , ... San Fransisko, or Sisko for short, is a German warmblood ... to pursue a career in dressage. According to Deborah, dressage came easy to ... ever worked with. Unfortunately, Sisko suffered an injury while playing in his pasture. ...
(Date:2/26/2019)... ... 2019 , ... The idea for Visikol began originally at ... tissue clearing technology for improved tissue characterization. From this initial idea, Visikol emerged ... primarily a services focused company. , Today, Visikol operates as a contract ...
(Date:2/16/2019)... TORONTO (PRWEB) , ... February 14, 2019 , ... ... data visualization, analytics, and knowledge sharing capability that also provides the flexibility for ... and play” functionality. It also provides a shared workbench to conduct quick analytics ...
Breaking Biology Technology:
Cached News: