HOME >> BIOLOGY >> NEWS
Molecular traffic cop directs cellular signals

Scientists report that a recently identified molecule functions as a molecular switch that influences the activity of key signaling molecules by restricting the location of the activated molecules within the cell. The research, published in the July issue of Developmental Cell, provides new insight into how a widely used signaling cascade can be spatially regulated to enhance the specificity of cellular responses.

The Ras/ERK MAP kinase signaling cascade is activated by many extracellular stimuli and is critical to a variety of cellular processes. The molecules that make up this cascade are present in different subcellular compartments and exactly where the cascade is activated depends on the extracellular stimulus. ERK activity can influence molecules in the cell cytoplasm or it can influence whether target genes in the nucleus are turned on or off. It is not known exactly how a particular stimulus can confine Ras/ERK MAP activity to a specific region of the cell.

A molecule called hSef was recently identified as an inhibitor of this cascade but the molecular mechanisms of inhibition are unclear. Dr. Eisuke Nishida from The Department of Cell and Developmental Biology at Kyoto University in Japan examined exactly how hSef influences Ras/ERK MAP kinase signaling in the cytoplasm and nucleus. When cells were stimulated with a common growth factor, hSef interacted with activated ERK in the cytoplasm. The inhibitor was only switched on when the Ras/ERK MAP kinase pathway was activated. Interestingly, activated hSef works not by directly inhibiting the activity of ERK, but by preventing activated ERK from entering the nucleus. When hSef levels were experimentally reduced, stimulus-dependant ERK activation in the nucleus increased dramatically.

These results demonstrate that the newly discovered inhibitor hSef is a signaling-dependent regulator of the Ras/ERK MAP kinase cascade that blocks MAP kinase influence on target genes by res
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
12-Jul-2004


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular marker predicts success of breast cancer treatment
9. Molecular image of genotoxin reveals how bacteria damage human DNA
10. Molecular mechanism found that may improve ability of stem cells to fight disease
11. Molecular midwives hold clues to the origin of life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/16/2018)... ... October 16, 2018 , ... Nanomedical Diagnostics ... a new publication titled, “ Graphene-based Biosensor for On-Chip Detection of Bio-Orthogonally Labeled ... R100 as a “new portable digital device for biosensing… that can be employed ...
(Date:10/11/2018)... ... October 09, 2018 , ... ... high-impact life science and biotechnology companies, announced today that it will host ... discuss their investment philosophies, explain their fund and deal structures, and describe ...
(Date:10/11/2018)... ... October 11, 2018 , ... ... vision behind the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL). The Institute, ... designed to advance biopharmaceutical manufacturing and workforce development in the United States. Biopharmaceuticals ...
Breaking Biology News(10 mins):
(Date:10/11/2018)... ... October 11, 2018 , ... ... of diseases like leukemia, lymphoma, sickle cell anemia, among others, and the medical ... Specialized Healthcare Logistics’ new e-book provides expert advice on ways to maintain the ...
(Date:10/5/2018)... ... October 04, 2018 , ... Earthres Group, Inc., a ... the company’s brand identity and better reflects its current breadth of markets and ... engineering expertise and related support services to clients in seven market sectors, and ...
(Date:10/2/2018)... ... 02, 2018 , ... The Alliance for Clinical Research Excellence ... of standards and testing of procedures for voluntary accreditation of clinical research sites. ... for Quality Management Systems and Chief Quality Officer, is underway in association with ...
(Date:9/27/2018)... ... 2018 , ... Consumers adopting new health care technologies like ... to a new Zeldis Research and Schlesinger Group study, “The Consumerization of Health ... of fitness and health wearables, remote monitoring, patient portals and other convenience products ...
Breaking Biology Technology:
Cached News: