Molecule that restricts mouse cells' potency could yield embryonic stem cells without the sacrifice of embryos

PHILADELPHIA Scientists at the University of Pennsylvania have identified a receptor that plays a key role in restricting embryonic stem cells pluripotency, their ability to develop into virtually any of an adult animals cell types. The work is the first demonstration of a mechanism by which pluripotency is lost in mammalian embryos, one that operates with nearly the precision of an on/off switch in mouse embryos.

With further study, the receptor, dubbed GCNF, could open the door to new ways of creating embryonic stem cells without the ethical concerns associated with sacrificing embryos. GCNF, short for germ cell nuclear factor, was detailed in a recent paper in the journal Developmental Cell.

"In a sense, were hoping that understanding what GCNF actually does as it shuts down genes will let us turn back the clock on cellular development," said senior author Hans R. Schler, professor of animal biology at Penns School of Veterinary Medicine. "This knowledge may permit us to convert ordinary adult cells back to embryonic stem cells for research purposes."

Schler, also the director of Penns Center for Animal Transgenesis and Germ Cell Research, said GCNF is the first factor known to repress the key gene Oct4, which is expressed in pluripotent embryonic cells. While GCNF is likely just one cog in a complex cellular machinery that dictates pluripotency among the cells of mouse embryos, Schlers team believes it is a crucial player: without GCNF, restriction of pluripotency does not occur properly and the embryo eventually dies.

"The identification of GCNF as a repressor of Oct4 expression opens up several new avenues for understanding Oct4 regulation and, therefore, the control of the pluripotent state," wrote Peter J. Donovan of Thomas Jefferson University in an analysis appearing in the November issue of Nature Genetics. "The identification of a nexus between Oct4 and GCNF provides some critical clues as to how the di

Contact: Steve Bradt
University of Pennsylvania

Page: 1 2

Related biology news :

1. Molecule awakens and maintains neural connections
2. Molecule that blocks key bacterial enzyme may lead to new antibiotics
3. Molecule found to be critical for kidney development
4. Molecule identified that contributes to essential cell functioning process
5. Molecules discovered that extend life in yeast, human cells
6. Molecule helps prevent inflammation and heart disease in fat-fed mice
7. Molecule offers insights into fertilization
8. Molecules designed to interfere with DNA upon signal
9. Molecule helps pupils respond to light
10. Molecule plays key role in cellular quality control machinery
11. Scientists Determine Atomic Structure Of Lego-Like Molecule That Self-Assembles Into Cells Cargo Capsule

Post Your Comments:

(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. ... a free webinar on Performing Quality Investigations: Getting to Root Cause. ... at no charge. , Incomplete investigations are still a major concern to the ...
(Date:6/22/2016)... DIEGO , June 22, 2016 ... that will allow them to produce up to ... from one lot within one week. These high-quality, ... time laboriously preparing cells and spend more time ... possible through a proprietary, high-volume manufacturing process that ...
Breaking Biology Technology:
Cached News: