HOME >> BIOLOGY >> NEWS
Molecule that restricts mouse cells' potency could yield embryonic stem cells without the sacrifice of embryos

PHILADELPHIA Scientists at the University of Pennsylvania have identified a receptor that plays a key role in restricting embryonic stem cells pluripotency, their ability to develop into virtually any of an adult animals cell types. The work is the first demonstration of a mechanism by which pluripotency is lost in mammalian embryos, one that operates with nearly the precision of an on/off switch in mouse embryos.

With further study, the receptor, dubbed GCNF, could open the door to new ways of creating embryonic stem cells without the ethical concerns associated with sacrificing embryos. GCNF, short for germ cell nuclear factor, was detailed in a recent paper in the journal Developmental Cell.

"In a sense, were hoping that understanding what GCNF actually does as it shuts down genes will let us turn back the clock on cellular development," said senior author Hans R. Schler, professor of animal biology at Penns School of Veterinary Medicine. "This knowledge may permit us to convert ordinary adult cells back to embryonic stem cells for research purposes."

Schler, also the director of Penns Center for Animal Transgenesis and Germ Cell Research, said GCNF is the first factor known to repress the key gene Oct4, which is expressed in pluripotent embryonic cells. While GCNF is likely just one cog in a complex cellular machinery that dictates pluripotency among the cells of mouse embryos, Schlers team believes it is a crucial player: without GCNF, restriction of pluripotency does not occur properly and the embryo eventually dies.

"The identification of GCNF as a repressor of Oct4 expression opens up several new avenues for understanding Oct4 regulation and, therefore, the control of the pluripotent state," wrote Peter J. Donovan of Thomas Jefferson University in an analysis appearing in the November issue of Nature Genetics. "The identification of a nexus between Oct4 and GCNF provides some critical clues as to how the di
'"/>

Contact: Steve Bradt
bradt@pobox.upenn.edu
215-573-6604
University of Pennsylvania
3-Dec-2001


Page: 1 2

Related biology news :

1. Molecule awakens and maintains neural connections
2. Molecule that blocks key bacterial enzyme may lead to new antibiotics
3. Molecule found to be critical for kidney development
4. Molecule identified that contributes to essential cell functioning process
5. Molecules discovered that extend life in yeast, human cells
6. Molecule helps prevent inflammation and heart disease in fat-fed mice
7. Molecule offers insights into fertilization
8. Molecules designed to interfere with DNA upon signal
9. Molecule helps pupils respond to light
10. Molecule plays key role in cellular quality control machinery
11. Scientists Determine Atomic Structure Of Lego-Like Molecule That Self-Assembles Into Cells Cargo Capsule

Post Your Comments:
(Date:7/9/2015)... 07, 2015 Research ... of the "Biometrics for Banking; Market & ... report to their offering. The adoption ... this growth and the forecast is that by ... for companies involved in delivering biometric systems to ...
(Date:7/8/2015)... , July 8, 2015  Trovagene, Inc. (NASDAQ: ... diagnostics, today announced the launch of a study ... Precision Cancer Monitoring℠ (PCM) technology for predicting response ... or a combination of the novel immunotherapy agents ... a PD-1 inhibitor. The 50-patient study will be ...
(Date:7/2/2015)... June 25, 2015 ... addition of the "Natural Language Processing Market ... IVR, OCR, Pattern & Image Recognition) - Worldwide ... The key vendors occupying the market ... Corporation, Microsoft Corporation, NetBase Solutions, SAS Institute Inc., ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2
(Date:8/3/2015)... , Aug. 3, 2015  ArroGen Group, ... its new Fingerprint Molecular Identification™ (FMID) technology Aug. ... conference in Sacramento, Calif. ... science, will enable law enforcement agents, district attorneys ... of criminal suspects. By analyzing chemical ...
(Date:8/3/2015)... WESTWOOD, Mass. , Aug. 3, 2015  Merck ... company for innovative and top-quality high-tech products in the ... together with the US-based company Nano-C, their development and ... field of organic photovoltaics (OPV). Merck KGaA, Darmstadt, ... participate in the growing OPV sector. Novel ...
(Date:8/3/2015)... 2015   Intrexon Corporation (NYSE: XON ... second quarter 2015 financial results after the market closes ... will host a conference call at 5:30 PM ET ... update. The conference call may be accessed ... asking to join the "Intrexon Corporation Call."  Participants may ...
(Date:7/31/2015)... , July 31, 2015 In today,s ... that help them drive positive health outcomes, improve ... source of patient care in their communities. At ... tradeshow and conference, AmerisourceBergen announced a new set ... Services Administration Organization and help independent pharmacies endure ...
Breaking Biology Technology:ArroGen Previews New Fingerprint Molecular Identification Technology 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 3Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 4Intrexon to Announce First Half and Second Quarter 2015 Financial Results and Host Conference Call on August 10th 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3
Cached News: