Molecules designed to interfere with DNA upon signal

Blacksburg, Va., March 24, 2003 -- Medical science's arsenal against cancer includes compounds that interfere with the DNA of cancer cells. However, these medicines often damage noncancer cells as well, making chemotherapy a sickening treatment. Many scientists are trying to develop compounds that can be released upon command in the presence of disease cells. Now, Virginia Tech researchers have developed a new molecule that early results show can be signaled to bind to target DNA and stop replication.

Karen Brewer, professor of chemistry at Virginia Tech, will present the research at the 225th national meeting of the American Chemical Society March 23-27 in New Orleans.

Brewer, whose group develops mixed-metal supramolecular complexes for a wide assortment of molecular devices, has been working for sometime on DNA binding agents and photo initiated DNA cleavage agents. At the meeting, she will talk about interactions with DNA using a complex of molecules with functions that allow it to bind to DNA and to stop replication.

"This is a new class of molecules," says Brewer. "The complex does not become toxic until it receives a light signal, at which point it cleaves the DNA so that it cannot replicate."

Results in test tubes and under the microscope with different cell lines have demonstrated that the specially constructed molecules can kill cells in the presence of light.

The researchers have applied for a patent through Virginia Tech Intellectual Properties Inc. (www.vtip.org). The technology has been licensed to Carilion Biomedical Institute of Roanoke, Va.

The poster, "Mixed-metal supramolecular complexes as photochemical molecular devices and DNA binding and photocleavage agents (Inor 357)," coauthored by Brewer, Alvin A. Holder of the University of West Indies, and R. Lee Williams, Shawn M. Swavey, and Mark Elvington, all of Virginia Tech, will be presented as part of the Coordination Chemistry session of the Divisi

Contact: Karen Brewer
Virginia Tech

Page: 1 2

Related biology news :

1. Molecules discovered that extend life in yeast, human cells
2. Designer Molecules: Largest Protein Ever Created From Scratch Has Implications For Novel Drug Delivery And Diagnostics
3. NYU And Rockefeller Scientists Design Molecules That Stymie A Notorious Bug
4. Synthetic Lock Binds Some Molecules, Excludes Others
5. UCSF Team Identifies Two Key Molecules In Asthma; Important Finding For New Therapies That Treat Disease At Cell Level
6. NYU Researchers Develop Simple, Predictable And Precise Technique For Arranging DNA Molecules Into Two-Dimensional Crystals
7. Virginia Tech Scientists Study Killer Molecules
8. Researcher Gains 30,000% Saving Using "Bargain Basement" Chemistry To Create Complex Industrially Useful Molecules
9. Biosensor Is A Model For Widespread Testing Of Chemicals, Molecules
10. Moving DNA Molecules With Magnetic Tweezers
11. Newly designed nanoparticle quantum dots simultaneously target and image prostate tumors in mice

Post Your Comments:

(Date:5/14/2020)... , ... May 14, 2020 , ... ... board for medical sales representatives, found the 2019 average medical sales rep total ... risk being shadowed by uncertainties amid the COVID-19 global crisis. , The MedReps ...
(Date:5/1/2020)... ... April 30, 2020 , ... Flagship ... Corritori Consulting Inc., a biopharmaceutical and regulatory services advisor. The companies now deliver ... Flagship and Corritori are taking a collaborative approach to empower more confident and ...
(Date:4/30/2020)... Del. (PRWEB) , ... April 29, 2020 , ... ... was well positioned for continued growth – delivering innovative solutions for a wide ... care, chemical, aerospace and government agencies. A month into the new decade, it ...
Breaking Biology News(10 mins):
(Date:5/30/2020)... ... May 29, 2020 , ... Medrio, Inc., the leading provider ... has enabled Cytovale, Inc., a medical technology company dedicated to revolutionizing diagnostics for ... first patient in (FPI) in just seven days. The Cytovale technology will allow ...
(Date:5/28/2020)... ... May 28, 2020 , ... The Security Industry ... leaders as the 2020 winners of the Women in Biometrics Awards – ... IDEMIA , Biometric Update and the SIA Women in Security Forum ...
(Date:5/21/2020)... Prairie, MN (PRWEB) , ... May 19, 2020 , ... ... to help patients get dental implants and bone grafting through PIEZOSURGERY® technology. ... tissues. This is often used to prepare a patient for dental implants, especially when ...
(Date:5/15/2020)... ... May 14, 2020 , ... RoosterBio ... banks and hMSC bioprocess systems, today announced the launch of its product ... vesicles (EVs). RoosterCollect™-EV-CC is the only system designed with hMSC-EV product developers ...
Breaking Biology Technology:
Cached News: