HOME >> BIOLOGY >> NEWS
Molecules discovered that extend life in yeast, human cells

BOSTON, MA Mice, rats, worms, flies, and yeast all live longer on a low-calorie diet, which also seems to protect mammals against cancer and other aging-related diseases. Now, in yeast cells, researchers at Harvard Medical School and BIOMOL Research Laboratories have for the first time found a way to duplicate the benefits of restricted calories in yeast with a group of compounds found in red wine and vegetables. One compound extended yeast life span by up to 80 percent. The molecules are also active in human cells cultured in the laboratory.

The findings are reported in the August 24 Nature advanced online edition. The research suggests a promising route to find and develop drugs to lengthen life and prevent or treat aging-related diseases.

The molecules belong to a familiar group of compounds known as polyphenols, such as the resveratrol found in red wine and the flavones found in olive oil. For these particular polyphenols, the beneficial effects seem to be independent of their famed antioxidant properties. Instead, the molecules activate sirtuins, a family of enzymes known to extend the life span of yeast and tiny lab round worms. In screening tests, the researchers found 17 molecules that stimulated SIRT1, one of seven human sirtuins, and the yeast sirtuin SIR2.

"We think sirtuins buy cells time to repair damage," said molecular biologist David Sinclair, assistant professor of pathology at Harvard Medical School and co-author of the new study. "There is a growing realization from the aging field that blocking cell death -- as long as it doesn't lead to cancer -- extends life span."

"The sirtuin stimulation provided by certain, but not all, polyphenols may be a far more important biological effect than their antioxidant action," said co-author Konrad Howitz, director of molecular biology at BIOMOL, a biochemical reagents company in Pennsylvania.

Calorie restriction (in mammals, reducing intake to 60 or 70 percent
'"/>

Contact: John Lacey
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
24-Aug-2003


Page: 1 2 3

Related biology news :

1. Molecules designed to interfere with DNA upon signal
2. Designer Molecules: Largest Protein Ever Created From Scratch Has Implications For Novel Drug Delivery And Diagnostics
3. NYU And Rockefeller Scientists Design Molecules That Stymie A Notorious Bug
4. Synthetic Lock Binds Some Molecules, Excludes Others
5. UCSF Team Identifies Two Key Molecules In Asthma; Important Finding For New Therapies That Treat Disease At Cell Level
6. NYU Researchers Develop Simple, Predictable And Precise Technique For Arranging DNA Molecules Into Two-Dimensional Crystals
7. Virginia Tech Scientists Study Killer Molecules
8. Researcher Gains 30,000% Saving Using "Bargain Basement" Chemistry To Create Complex Industrially Useful Molecules
9. Biosensor Is A Model For Widespread Testing Of Chemicals, Molecules
10. Moving DNA Molecules With Magnetic Tweezers
11. New hydrothermal vents discovered as South Pacific Odyssey research begins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... PHOENIX (PRWEB) , ... August 03, 2020 , ... ... the company announced a new partnership with medical equipment manufacturer, Spectrum Solutions, to ... its clients to strengthen their laboratory supply chain for more than 10 years. ...
(Date:7/31/2020)... ... 30, 2020 , ... Justin Zamirowski to lead upcoming launches ... focus on Type 2 diabetes and associated comorbidities. , Justin brings over 20 ... classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ efforts ...
(Date:7/18/2020)... ... 16, 2020 , ... A study has been published in ... active noise control device to attenuate typical noises in a simulated neonatal intensive ... alarm sounds from patient monitors, ventilators and other bedside devices that would affect ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its ... MediVet Biologics since its formation in 2016, the company is relaunching itself under the ... on its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... that can combine up to three different materials for use with CRM, neurostimulation, ... up to three materials to meet specific design requirements, performance, and cost criteria; ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... life sciences industry, today announced the release of its signature product called ... Science Liaisons (MSLs) and other field medical professionals. , Beacon helps ...
(Date:7/18/2020)... DAYTON, Ohio (PRWEB) , ... July 16, 2020 ... ... clinical data solutions to aid in the early detection and prevention of high-burden ... partnership to enable US-based hospitals and healthcare organizations to utilize existing data in ...
Breaking Biology Technology:
Cached News: