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Monkeys that drink heavily develop signs of liver disease, Wake Forest study shows

WINSTON-SALEM, N.C. Monkeys that choose to drink alcohol heavily develop early signs of alterations in the liver, according to research by a team of investigators from Wake Forest University School of Medicine.

The research, presented today at the annual meeting of the Research Society on Alcoholism in San Francisco, describes a chemical found in the urine of monkeys also found in human alcoholics, and liver biopsies that show development of "fatty liver" -- another common finding in heavily drinking people.

Carol C. Cunningham, Ph.D., professor of biochemistry said, "One of the unique features of using these monkeys as a model for alcoholic liver disease is that these monkeys self-administer alcohol."

Some of the monkeys choose to only take a small amount of alcohol -- paralleling the social drinkers; some consume a moderate amount -- "like regular drinkers who are not in jeopardy of developing alcoholic liver disease," and some are heavy drinkers, who become intoxicated, most prone to changes in the liver.

"In some respects, this group of monkeys mimic the human situation," he said, except "we don't have any monkeys that don't drink any (alcohol) -- they all drink something."

First, Cunningham and his colleagues in the Center for the Neurobehavioral Study of Alcohol found evidence in the urine of "oxidative damage" to the liver. He explained that the metabolism of alcohol in the liver generates "reactive oxygen" which can damage liver tissue. To track that, they chose to follow damage to lipids, since cell structure is influenced by lipids.

The damaged liver produces isoprostanes in the urine -- tiny pieces of oxidized lipids. "There is a dramatic increase in the level of these lipid products in heavy drinkers," Cunningham

said. There are some isoprostanes in the urine of moderately drinking monkeys and only low amounts in the light drinkers.

Second, biopsies of the livers of the heavily d
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Contact: Robert Conn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
2-Jul-2002


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