HOME >> BIOLOGY >> NEWS
More aggressive breast cancer tumors found in African American women

New Haven, Conn.--A genetic mutation related to a more aggressive form of breast cancer occurs four times more often in African American patients than their white counterparts, Yale researchers report in the August 9, 2004 online edition of the journal Cancer.

In the United States, African-American women have a lower incidence of breast cancer than white women, but they have a higher mortality rate. The disease also develops at an earlier age and is more aggressive in African-American women. To explore the reasons for the differences, Beth A. Jones, assistant professor in the Department of Epidemiology and Public Health at Yale School of Medicine, and her colleagues studied the effects of alterations in a tumor suppressor gene called p53.

The team looked at how the patterns of alterations of genes related to worse prognosis differed between African-American and white women. They examined the breast tumors of 145 African-American and 177 white women and found that African-American women were four times more likely than white women to show significant alterations in the p53 gene.

"This is the first population-based study to report a clearly significant increase in p53 mutations that is independent of race differences in other tumor characteristics, socioeconomic status and other biomedical and lifestyle factors", said Jones. The authors also confirmed that tumors in African-American women were more likely than those in whites to display tumor characteristics associated with poor prognosis. With few population-based studies having access to detailed patient information and tumor information assessed in a single laboratory using standardized methodology, Jones said confirmation of these earlier reports is an important contribution to this area of research.

Past explanations for the racial/ethnic differences included socioeconomic factors, nutrition and healthcare behavior, but Jones stresses that while many factors contribute to the
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
9-Aug-2004


Page: 1 2

Related biology news :

1. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
2. Early predictor of breast cancer aggressiveness
3. Genetic screening study at Stanford IDs most aggressive adult leukemia strains
4. Gliomas molecular fingerprint predicts how aggressive tumor will be
5. Cancer biologists and a cardiologist take a new look at aggressive tumors
6. Anthrax threat needs aggressive government action plan, say researchers
7. Researchers identify cause of aggressive childhood cancer
8. Discovery sheds light on how breast cancer cells progress to more aggressive forms
9. Stanford researcher advocates aggressive, preventive anal cancer treatment
10. New gene-silencing enzyme discovered: Implications seen for treating aggressive cancers
11. More chance of a cure for patients with common and aggressive form of blood cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... (PRWEB) , ... July 30, 2020 , ... ... Research (SBIR) Phase II contract awarded by the Joint Science & Technology Office—Chemical ... this project is to develop, optimize, and scale-up a highly efficient mammalian cell ...
(Date:7/22/2020)... ... July 21, 2020 , ... ... in technology and compliance, announces a new solution to manage regulated workloads on ... layer of their technology stack complies with FDA and global regulations. USDM's new ...
(Date:7/18/2020)... ... ... Commercial launch readiness is a critical stage in a product life cycle. While ... global economic downturn will only increase price pressures overall for the industry. The era ... from every product launch is critical. However, history shows that only a third of ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... The SDX® Respiratory Gating System ... has reached its 20th anniversary of worldwide use. Introduced in the US over ... including University of Pennsylvania, University of Michigan, University of Maryland, University of California ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said ... on the market and we were pleased that the IFT jury recognized that.” reFRESH™ ... creating a natural way to extend the shelf life and improve the safety of ...
(Date:7/10/2020)... , ... July 09, 2020 ... ... company, announced today that Massachusetts Institute of Technology (MIT) has expanded the ... license allows PathSensors to move into the point-of-care diagnostic market, focusing initially ...
(Date:7/7/2020)... ... 2020 , ... Bio-IT World has announced the winners of ... University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were ... outstanding examples of how technology innovations and strategic initiatives can be powerful forces ...
Breaking Biology Technology:
Cached News: