HOME >> BIOLOGY >> NEWS
Mouse embryo hints at how mammalian body forms

, while those opposite the polar body became located at the other end.

The fact that the cells projected in a uniform and consistent way suggests, suggests, the researchers say, that the early blastocyst's axis of bilateral symmetry predicts the spatial patterning of the post-implantation embryo.

"This is the first evidence that the polarity at post-implantation stages, when the body plan is established, can be traced back to events before implantation," says Zernicka-Goetz."

The fact that the fertilized egg of the mouse - and probably other mammals -- share this principle of early organization with other organisms offers fuel for future studies.

"Knowing what we now do, the mouse embryo model will be that much more effective for these studies, and the other models studied may be informative of things we hadn't anticipated; in other words, the finding may make frogs more germane to us," says Zernicka-Goetz.

Researchers have already identified molecular systems in frogs that are strongly implicated in inducing gastrulation, and these systems could play an important role in animals with backbones, including mammals, the researchers say. It is possible that the as-yet-unidentified molecular mechanisms of body formation in the mouse embryo could be similar to those seen in the frog.

The new results, the researchers say, could also prove useful for gaining control over embryonic stem cells. "Looking at what's going on molecularly in embryos at the time of gastrulation could provide insight into the molecular forces underlying embryonic stem cell differentiation," says Pedersen. "This could provide the missing clue as to how to control the differentiation of stem cells in vitro."

The most likely way to get embryonic stem cells to differentiate into specific cell lines, he surmises, is to do what the embryo does - first make them differentiate into endoderm, mesoderm and ectoderm. Once this has been achiev
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
19-Dec-1999


Page: 1 2 3 4 5

Related biology news :

1. Half-million dollar landmark achieved for the Methuselah Mouse Prize
2. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
3. Mouse brain stem cells capable of converting into blood vessel cells
4. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
5. Mouse embryonic germ cells and male gametes created in the lab
6. Mouse, stripped of a key gene, resists diabetes
7. Mouse model of schizophrenia could speed identification of new antipsychotic drugs
8. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
9. Mouse model offers new explanation for kidney disease and failure
10. Mouse study suggests mammoth evolutionary change
11. Mouse genetic model for spongiform brain diseases

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse embryo hints how mammalian body forms

(Date:8/21/2014)... pancreas digesting itself resulting in severe abdominal pain, vomiting ... 20,000 patients are diagnosed with the disease resulting in ... is restricted to intravenous fluid and nutritional support. ... Sciences, who led the research, said "The major causes ... and excessive alcohol intake combined with a high fat ...
(Date:8/20/2014)... SALT LAKE CITY Researchers at Huntsman Cancer Institute (HCI) ... mutated forms of the gene that encodes BCR-ABL, the ... (CML). According to the American Cancer Society, nearly 6,000 ... , Drugs already in use, called tyrosine kinase inhibitors ... disease. They do not cure CML but control it ...
(Date:8/20/2014)... State University, the Wellcome Trust Sanger Institute and the ... Mycobacterium pinnipedii from skeletons found in Peru ... is a relative of the TB bacterium that affects ... These researchers assume that seals carried the pathogens from ... lions was unexpected" comments Sebastien Gagneux, from the Swiss ...
Breaking Biology News(10 mins):Insulin offers new hope for the treatment of acute pancreatitis 2Blueprint for next generation of chronic myeloid leukemia treatment 2
(Date:8/21/2014)... 2014 Telomere Biosciences, LLC (Telomere Biosciences) ... for Dogs" with Telomerase Activation Complex , ... world for dogs. Telomeres are the protective caps ... body. A wealth of ground-breaking research by some ... and Aging, including Nobel laureates, has demonstrated a ...
(Date:8/21/2014)... , Aug. 21, 2014 ... Immune Pharmaceuticals Inc., a biotechnology company, on its ... Immune previously traded on OTCQX®, the best marketplace ... OTC Markets Group. Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... on the successful execution of its growth strategy ...
(Date:8/21/2014)... Ontotext S4 , The Self Service Semantic ... Now the same enterprise hardened text mining, Linked Data ... is available to start-ups and mid-size businesses at a ... do not have resources to evaluate and prototype enterprise ... there is no need for on premise hardware provisioning ...
(Date:8/20/2014)... RALEIGH, N.C. , Aug. 20, 2014 /PRNewswire/ ... clinical research services located in Raleigh, ... Bradford Evans as Vice President of ... Administration, Brad will oversee all corporate processes, including ... to joining Clintrax Global, Brad worked as an ...
Breaking Biology Technology:Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4Clintrax Global, Inc. Announces Addition to Executive Team 2
Cached News: