HOME >> BIOLOGY >> NEWS
Mouse embryo hints at how mammalian body forms

, while those opposite the polar body became located at the other end.

The fact that the cells projected in a uniform and consistent way suggests, suggests, the researchers say, that the early blastocyst's axis of bilateral symmetry predicts the spatial patterning of the post-implantation embryo.

"This is the first evidence that the polarity at post-implantation stages, when the body plan is established, can be traced back to events before implantation," says Zernicka-Goetz."

The fact that the fertilized egg of the mouse - and probably other mammals -- share this principle of early organization with other organisms offers fuel for future studies.

"Knowing what we now do, the mouse embryo model will be that much more effective for these studies, and the other models studied may be informative of things we hadn't anticipated; in other words, the finding may make frogs more germane to us," says Zernicka-Goetz.

Researchers have already identified molecular systems in frogs that are strongly implicated in inducing gastrulation, and these systems could play an important role in animals with backbones, including mammals, the researchers say. It is possible that the as-yet-unidentified molecular mechanisms of body formation in the mouse embryo could be similar to those seen in the frog.

The new results, the researchers say, could also prove useful for gaining control over embryonic stem cells. "Looking at what's going on molecularly in embryos at the time of gastrulation could provide insight into the molecular forces underlying embryonic stem cell differentiation," says Pedersen. "This could provide the missing clue as to how to control the differentiation of stem cells in vitro."

The most likely way to get embryonic stem cells to differentiate into specific cell lines, he surmises, is to do what the embryo does - first make them differentiate into endoderm, mesoderm and ectoderm. Once this has been achiev
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
19-Dec-1999


Page: 1 2 3 4 5

Related biology news :

1. Half-million dollar landmark achieved for the Methuselah Mouse Prize
2. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
3. Mouse brain stem cells capable of converting into blood vessel cells
4. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
5. Mouse embryonic germ cells and male gametes created in the lab
6. Mouse, stripped of a key gene, resists diabetes
7. Mouse model of schizophrenia could speed identification of new antipsychotic drugs
8. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
9. Mouse model offers new explanation for kidney disease and failure
10. Mouse study suggests mammoth evolutionary change
11. Mouse genetic model for spongiform brain diseases

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse embryo hints how mammalian body forms

(Date:10/28/2014)... . , How ... when times are lean? By studying wild chimpanzees in ... the Max Planck Institute for Evolutionary Anthropology in Leipzig, ... can acquire extra energy needed to maintain large, costly ... more en route to breakfast sites containing fruits that ...
(Date:10/28/2014)... moving activity in a novel environment are linked ... to an experimental study completed at the University ... Fisheries Research Institute. The study used novel, long-term ... angling trials to analyse if behaviours predict the ... traditional and enriched hatchery rearing environments. Based ...
(Date:10/27/2014)... species of the West Antarctic Peninsula (WAP), one of ... the average annual temperature in the Antarctic Peninsula has ... Celsius during winter. , As the WAP climate ... to a warmer, sub-polar system with more rain. , ... local weather conditions and the weight of Adélie penguin ...
Breaking Biology News(10 mins):The early chimp gets the fig 2The early chimp gets the fig 3Fish 'personality' linked to vulnerability to angling 2University of Delaware study connects penguin chick weights to local weather conditions 2University of Delaware study connects penguin chick weights to local weather conditions 3
(Date:10/27/2014)... Oct. 27, 2014 Kalorama Information says that ... concern in the United States ... healthcare market researcher said the FDA,s Emergency Use Authorization (EUA) ... tests for the detection of the Ebola virus was ... Kalorama routinely assess the IVD industry and its biennial ...
(Date:10/27/2014)... The report “Smart Highway Market by Technology (Intelligent ... by Display (Variable Message Signs, Digital Signage) - ... into various sub-segments with in-depth analysis and forecasting ... restraints for this market with insights into trends, ... and 37 figures spread through 141 pages in-depth ...
(Date:10/26/2014)... The report "Data Center Networking Market [Ethernet switches, ... Appliances]: Global Advancements, Worldwide Forecasts & Analysis (2013-2018)" ... into various segments with an in-depth analysis and ... factors driving this market, various restraints and challenges, ... roadmaps. , Browse 106 market data tables and ...
(Date:10/25/2014)... BioProcess International (BPI), a business-to-business ... BioProcess International Awards. The awards celebrate the outstanding ... technology applications that will allow the industry to ... patient base. , Winners and finalists were honored ... entertaining and exciting awards dinner and ceremony yesterday ...
Breaking Biology Technology:Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4BioProcess International Announces Winners of the 2014 BioProcess International Awards 2BioProcess International Announces Winners of the 2014 BioProcess International Awards 3BioProcess International Announces Winners of the 2014 BioProcess International Awards 4BioProcess International Announces Winners of the 2014 BioProcess International Awards 5
Cached News: