HOME >> BIOLOGY >> NEWS
Mouse embryo hints at how mammalian body forms

, while those opposite the polar body became located at the other end.

The fact that the cells projected in a uniform and consistent way suggests, suggests, the researchers say, that the early blastocyst's axis of bilateral symmetry predicts the spatial patterning of the post-implantation embryo.

"This is the first evidence that the polarity at post-implantation stages, when the body plan is established, can be traced back to events before implantation," says Zernicka-Goetz."

The fact that the fertilized egg of the mouse - and probably other mammals -- share this principle of early organization with other organisms offers fuel for future studies.

"Knowing what we now do, the mouse embryo model will be that much more effective for these studies, and the other models studied may be informative of things we hadn't anticipated; in other words, the finding may make frogs more germane to us," says Zernicka-Goetz.

Researchers have already identified molecular systems in frogs that are strongly implicated in inducing gastrulation, and these systems could play an important role in animals with backbones, including mammals, the researchers say. It is possible that the as-yet-unidentified molecular mechanisms of body formation in the mouse embryo could be similar to those seen in the frog.

The new results, the researchers say, could also prove useful for gaining control over embryonic stem cells. "Looking at what's going on molecularly in embryos at the time of gastrulation could provide insight into the molecular forces underlying embryonic stem cell differentiation," says Pedersen. "This could provide the missing clue as to how to control the differentiation of stem cells in vitro."

The most likely way to get embryonic stem cells to differentiate into specific cell lines, he surmises, is to do what the embryo does - first make them differentiate into endoderm, mesoderm and ectoderm. Once this has been achiev
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
19-Dec-1999


Page: 1 2 3 4 5

Related biology news :

1. Half-million dollar landmark achieved for the Methuselah Mouse Prize
2. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
3. Mouse brain stem cells capable of converting into blood vessel cells
4. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
5. Mouse embryonic germ cells and male gametes created in the lab
6. Mouse, stripped of a key gene, resists diabetes
7. Mouse model of schizophrenia could speed identification of new antipsychotic drugs
8. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
9. Mouse model offers new explanation for kidney disease and failure
10. Mouse study suggests mammoth evolutionary change
11. Mouse genetic model for spongiform brain diseases

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse embryo hints how mammalian body forms

(Date:3/31/2015)... YORK , March 31, 2015   Guidepoint ... the launch of the Post-Surgical Pain Management TRACKER, part ... products tracking usage trends in the medical device and ... access to data including treatment volumes, market share, and ... the pain associated with joint surgery. The ...
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has announced ... 2015-2019" report to their offering. The ... at a CAGR of 23.5 percent over the period ... and the growth prospects of the Global Iris Recognition ... size, the report considers the revenue generated from sales ...
(Date:3/24/2015)... , March 24, 2015   Crossmatch ™, ... today announced that its U.are.U ® 4500 ... Goorin Bros . to achieve PCI compliance ... secures access to the POS terminal, protecting the ... of data breaches. With one-third ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
(Date:4/21/2015)... RESEARCH TRIANGLE PARK, N.C. , April 21, 2015 ... announced today that it will release its first quarter ... 28, 2015. United Therapeutics will host a ... a.m. Eastern Time.  The teleconference is accessible by dialing ... the teleconference will be available for one week and ...
(Date:4/21/2015)... Whether it’s used for troubleshooting in a factory, ... Kessler CineDrive in a cinematic studio setting, or ... is designed to help any shooter create vivid high-speed ... the TS5-H offers the same convenient touchscreen controls and streamlined ... According to Tom Boldt for Fastec, “We believe that compelling ...
(Date:4/20/2015)... IL (PRWEB) April 20, 2015 ... of its 12th clinical research site: PMG Research of ... assumed operation of the clinical research department at ... outside the Southeast to a second region within the ... multi-specialty physician practice enhances PMG’s access to an additional ...
(Date:4/20/2015)... , April 20, 2015  Eli Lilly and Company ... from several targeted cancer therapies, reflecting Lilly,s diverse oncology ... Annual Meeting 2015, held April 18-22 in ... Discoveries to Patients" is the theme of this year,s ... commitment to broadening its portfolio of therapies that accelerate ...
Breaking Biology Technology:Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 2Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 4Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 5Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 6
Cached News: