HOME >> BIOLOGY >> NEWS
Mouse model links alcohol intake to marijuana-like brain compounds

Brain molecules similar to the active compound in marijuana help to regulate alcohol consumption, according to new reports by scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, and a separate NIAAA-supported group at several New York state research institutions.

In studies conducted with a strain of mice known to have a high preference for alcohol, the scientists found greatly reduced alcohol intake in mice specially bred to lack CB1, the brain receptor for innate marijuana-like substances known as endocannabinoids. The effect was age dependent, the Bethesda group found. The New York scientists showed that the endocannabinoid system activates a brain region known as the nucleus accumbens, which plays a major role in mediating the rewarding effects of alcohol. Both groups had shown that alcohol intake among normal mice of the same alcohol-preferring strain could be reduced by treating the animals with a drug that blocks CB1 receptors in the brain.

The new reports appear in the early online versions of the Proceedings of the National Academy of Sciences, Volume 20, Number 3, at www.pnas.org and the Journal of Neurochemistry, Volume 24, Number 4, at www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jnc in the week beginning January 20, 2003 (specific dates to be determined).

"These are important findings," notes NIAAA Director Ting-Kai Li, M.D. "Implicating yet another neurochemical mechanism in alcohol consumption opens another potential avenue for the development of new pharmacologic agents to prevent and treat alcohol problems."

The brain's multiple communication pathways employ a wide variety of signaling molecules known as neurotransmitters to relay messages from one brain cell to another. Researchers have found that alcohol affects numerous neurot
'"/>

Contact: Ann Bradley
abradley@willco.niaaa.nih.gov
301-443-0595
NIH/National Institute on Alcohol Abuse and Alcoholism
20-Jan-2003


Page: 1 2 3

Related biology news :

1. Half-million dollar landmark achieved for the Methuselah Mouse Prize
2. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
3. Mouse brain stem cells capable of converting into blood vessel cells
4. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
5. Mouse embryonic germ cells and male gametes created in the lab
6. Mouse, stripped of a key gene, resists diabetes
7. Mouse model of schizophrenia could speed identification of new antipsychotic drugs
8. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
9. Mouse model offers new explanation for kidney disease and failure
10. Mouse study suggests mammoth evolutionary change
11. Mouse genetic model for spongiform brain diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... and BANGALORE, India , April 28, ... Systems, a product subsidiary of Infosys (NYSE: INFY ... announced a global partnership that will provide end ... use mobile banking and payment services.      (Logo: ... key innovation area for financial services, but it also plays ...
(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys ... founding CEO, Barrett Bready , M.D., who returned ... of the original technical leadership team, including Chief Technology ... of Product Development, Steve Nurnberg and Vice President of ... to the company. Dr. Bready served as ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... 2016 Q BioMed Inc. (OTCQB: QBIO), ... a featured presenter at the 5th Annual Marcum MicroCap Conference ... City at the Grand Hyatt Hotel. ... Inc. CEO, is scheduled to begin at 11a.m ET in ... strategy, recent developments and outline milestones for the balance of ...
(Date:5/25/2016)... ... 2016 , ... Lajollacooks4u has become a rising hotspot for specialized team building ... top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm and Elsevier, have ... experience. , Each event kicks off with an olive oil and salt-tasting competition. ...
(Date:5/25/2016)... ... , ... Scientists at the University of Athens say they have evidence that ... the research that could lead to one good one. Surviving Mesothelioma has just posted ... , The team evaluated 98 mesothelioma patients who got a second kind ...
(Date:5/24/2016)... --  MedyMatch Technology Ltd ., the data analytics healthcare company ... tools in the emergency room, announced today that it has ... Industries (IATI) BioMed Conference. The Conference is ... Life Sciences and Technology Week, and is being held May ... Tel Aviv, Israel . Gene Saragnese , ...
Breaking Biology Technology:
Cached News: