HOME >> BIOLOGY >> NEWS
Mouse model of schizophrenia could speed identification of new antipsychotic drugs

Howard Hughes Medical Institute researchers have produced a genetically altered mouse that exhibits behavioral abnormalities that are strikingly similar to those observed in humans with schizophrenia.

The scientists report that they have already used insights from studying the mouse to identify a genetic variant associated with schizophrenia in humans.

According to the researchers, the findings could well mean that they have identified a molecular signaling pathway involved in the origin of schizophrenia, which affects about one percent of the population. If so, the search for drugs affecting that pathway could yield a new class of antipsychotic drugs that more precisely and effectively treat the disorder.

The researchers, led by Howard Hughes Medical Institute investigator Susumu Tonegawa at the Massachusetts Institute of Technology, published their findings June 30, 2003, in two articles in the early edition of the Proceedings of the National Academy of Sciences (PNAS). Tonegawa collaborated on the studies with researchers from Duke University Medical Center, The Rockefeller University and the Columbia University College of Physicians and Surgeons.

In their latest studies, Tonegawa and his colleagues built on their earlier research on a genetically engineered mouse, which had been specifically altered to knock out the gene for the enzyme calcineurin only in the animal's forebrain. Calcineurin is an enzymatic switch that plays regulatory roles in both the immune system and the brain. Until a brain-specific knockout mouse was developed in Tonegawa's laboratory, it had not been possible to pinpoint the enzyme's function in the brain. In earlier studies, Tonegawa and his colleagues found that the mutant mouse showed severe, specific deficits in a type of short-term memory called working memory.

Although schizophrenics show similar memory deficits, sai
'"/>

Contact: Avice Meehan
meehana@hhmi.org
301-215-8855
Howard Hughes Medical Institute
30-Jun-2003


Page: 1 2 3

Related biology news :

1. Half-million dollar landmark achieved for the Methuselah Mouse Prize
2. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
3. Mouse brain stem cells capable of converting into blood vessel cells
4. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
5. Mouse embryonic germ cells and male gametes created in the lab
6. Mouse, stripped of a key gene, resists diabetes
7. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
8. Mouse model offers new explanation for kidney disease and failure
9. Mouse study suggests mammoth evolutionary change
10. Mouse genetic model for spongiform brain diseases
11. Mouse model links alcohol intake to marijuana-like brain compounds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... ... August 15, 2019 , ... Serialization deadlines in the US ... complex, and aggregation becomes fully applied in the United States in 2023, pharmaceutical ... , Until now, most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required ...
(Date:8/14/2019)... ... ... Representatives with MyBioGate announced that China Focus@Biotech Week will be held September 10 ... connect with Chinese pharma and investors in healthcare innovation,ā€ said Miao Guo, Vice President ... a part of Biotech Week Boston ā€“ the annual biotech festival at the No. ...
(Date:8/6/2019)... DURHAM, N.C. (PRWEB) , ... August 06, 2019 ... ... Medicine (SCTM) identifies a computational modeling system that could have far-reaching implications for ... called partial least squares regression (PLSR), is able to predict which stem cell ...
Breaking Biology News(10 mins):
(Date:7/30/2019)... ... July 30, 2019 , ... The summer season has been ... Not only has the company already hosted many of its signature cooking classes ... its guests. , With Lajollacooks4uā€™s Private Cooking Parties, guests prepare and enjoy a ...
(Date:7/19/2019)... ... July 18, 2019 , ... ... Everest,ā€ will be joining forces with California-based charity Coalition Duchenne for its 9th ... Coalition Duchenne raises awareness and funding for Duchenne muscular dystrophy and was founded ...
(Date:7/11/2019)... LAS VEGAS (PRWEB) , ... July 11, 2019 , ... ... 2019, R3 provided complimentary regenerative therapies to eight military Veterans under the R3 Heroes ... procedures being complimentary. , The R3 Heroes Program allow anyone to nominate a military ...
(Date:6/26/2019)... LAS VEGAS (PRWEB) , ... June 26, 2019 , ... ... biofield energy treatment on improving physicochemical properties of Magnesium Gluconate, which can prove to ... Over 125% alteration of characteristic differentiation peak, change in crystallite size , ...
Breaking Biology Technology:
Cached News: