HOME >> BIOLOGY >> NEWS
Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis

DALLAS Aug. 30, 2004 Mice with specific genetic mutations exhibit behavior similar to human psychosis, report UT Southwestern Medical Center at Dallas researchers, providing further support to the notion of a genetic link to schizophrenia.

The researchers genetically engineered mice with a mutation in the gene NPAS3, a mutation in the gene NPAS1 or a mutation in both genes. Both genes encode proteins that switch other genes on and off in brain cells.

"These mice display certain deficits that are potentially consistent with schizophrenia," said Dr. Steven McKnight, chairman of biochemistry at UT Southwestern and senior author of the study that will appear in an upcoming issue of the Proceedings of the National Academy of Sciences and is to be posted online this week.

"It's too early to tell whether the abnormal behavior we observed in these mutated mice can be directly connected with human disease. On the other hand, we find it intriguing that members of a Canadian family carrying a mutation in the human NPAS3 gene have been reported to suffer from schizophrenia."

Normal mice in a pen will climb over each other and interact, but the mice with the genetic mutations fail to socialize in this way. Instead, the mutants dart about wildly, avoiding interaction with their normal siblings.

In addition, the mutant mice do not have a normal startle response, and have a distinct reduction of a protein called reelin in their brains. Other researchers have shown in postmortem examinations of the brain tissue of schizophrenics that these patients have a reduction in reelin, said Dr. McKnight.

Schizophrenics also have problems socializing and often have enhanced physical activity, similar to that of the mutant mice. An impaired startle response, Dr. McKnight said, also may lead to a schizophrenia diagnosis.

More than 2 million Americans are affected by schizophrenia, according to the National Insti
'"/>

Contact: Amanda Siegfried
Amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
30-Aug-2004


Page: 1 2

Related biology news :

1. Half-million dollar landmark achieved for the Methuselah Mouse Prize
2. Mouse brain stem cells capable of converting into blood vessel cells
3. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
4. Mouse embryonic germ cells and male gametes created in the lab
5. Mouse, stripped of a key gene, resists diabetes
6. Mouse model of schizophrenia could speed identification of new antipsychotic drugs
7. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
8. Mouse model offers new explanation for kidney disease and failure
9. Mouse study suggests mammoth evolutionary change
10. Mouse genetic model for spongiform brain diseases
11. Mouse model links alcohol intake to marijuana-like brain compounds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2020)... (PRWEB) , ... June 11, 2020 , ... ... DNA services, announces a significant expansion of its forensic genealogy team. Bode’s ... and attorneys through proven forensic genealogy and DNA analysis methods. The team has ...
(Date:6/11/2020)... ... , ... Superior Controls, Inc. , an E Technologies Company and leading ... sciences industry, is pleased to announce the recent hiring of Ray Boudreau, who will ... Hampshire office. In his new role, Boudreau will use his extensive experience with ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed to have ... our attendees, staff, and the public. We remain committed to creating a global ... collaborate virtually,” said Julie Sutcliffe, President of WMIS. , The abstract ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... WESTMINSTER, Colo. (PRWEB) , ... ... ... providers of expert tissue data insights, today announced that the launch of ... PD-L1 results along with data about the tumor microenvironment (TME). , “Flagship’s ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 pandemic ... drug treatment. In an effort to better understand the cellular responses to COVID-19, ... imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced molecules ...
(Date:6/28/2020)... ... 26, 2020 , ... The Security Industry Association ... opposition to the recently introduced bicameral Facial Recognition and Biometric Technology Moratorium ... use of nearly all biometric and related image analytics technologies, incorrectly labeling all ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... indoor environments, announced today that Derek Fournier has been appointed CEO and President. ... the Board, effective immediately. , “DeCurtis Corporation has been on an incredible ...
Breaking Biology Technology:
Cached News: