HOME >> BIOLOGY >> NEWS
Mouth microbes may help shape immune system, says Stanford research team

STANFORD, Calif. - The immune system may be shaped by some of the very agents it exists to fight, according to research by David Relman, MD, associate professor of medicine and of microbiology and immunology at Stanford University School of Medicine.

"Microbes not only provide functions that promote health, but may actually guide the stages of our own immune system development," said Relman. "It seems reasonable to propose that only until we have an idea of the make-up and variability of the microbial ecosystems living within us do we begin to get an idea of the mechanisms underlying the functions they perform, such as immune system maturation and defense against pathogens."

Relman will present an overview of his lab's work on this subject, along with some new findings Feb. 16 as part of the "Innate Immunity and Oral Health" program at the annual meeting of the American Association for the Advancement of Science in Seattle.

The mouth provides a thriving community of microbes and a unique field in which to study how these tiny creatures interact with their hosts. Relman's group has concentrated efforts on the subgingival crevice - the deep gap between the gums and teeth - in their search for microbes. Even though almost 500 bacterial strains or species have been identified in this oral pocket, Relman believes there remains a substantial amount to be learned about their behavior and response to perturbation, such as brushing and flossing, and environmental insults such as being attacked by the immune system.

Some of the most basic kinds of questions remain unanswered in the microbial world, said Relman. While there is a general consensus that bacteria play a role in causing gum disease, no single microbe has been implicated as the culprit. "The details on how oral microbes cause disease is probably not a simple story," said Relman. "One agent does not equal one disease. There are complex interactions between members of the oral flora
'"/>

Contact: Mitzi Baker
mitzibaker@stanford.edu
650-725-2106
Stanford University Medical Center
16-Feb-2004


Page: 1 2

Related biology news :

1. Foot-and-Mouth disease: Can research offer solutions? Science feature examines prevention and detection efforts
2. First Study To Take Bacteria Directly From Patients Mouths Further Supports Possible Link Between Gum And Heart Disease
3. Finding the hole in the defenses of cavity-creating microbes
4. Figs may inhibit growth and survival of harmful microbes in food
5. Discovery of tiny microbes in ancient Greenland glacier may define limits for life on Earth
6. Small, cold, & hungry: Ultra-small microbes from 120,000-year-old glacier ice sample
7. Antibiotics alter GI tract microbes and increase lung sensitivity to allergens
8. Researchers discover 1.2 million new genes in Sargasso Sea microbes
9. Fuel-cell microbes double duty: treat water, make energy
10. Navy enlists microbes to cut costs
11. Researchers probe how microbes speed up acid production at mining sites

Post Your Comments:
(Date:11/10/2014)... on U.S. store shelves in early 2010, and people ... small packets can be tossed into a washing machine ... powder. The convenience, though, has come with risks for ... Nationwide Children,s Hospital found that from 2012 through 2013, ... younger than 6 years of age swallowing, inhaling, or ...
(Date:11/6/2014)... Most cancer deaths occur because of metastasis, yet ... has been slow. , "It,s been particularly challenging ... Taran Gujral, research fellow in systems biology at ... aren,t detected until after they,ve already metastasized." , ... culprit that should help researchers better understand how ...
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Migration negation 2Migration negation 3The female nose always knows: Do women have more olfactory neurons? 2
(Date:11/26/2014)... The North America Thermal Protective ... for detailed analysis of the growth trends and ... $616.3 million by 2018, growing at a CAGR ... through the TOC of the North America Thermal ... of the in-depth analysis and industry segmentation supported ...
(Date:11/26/2014)... 26, 2014 On January, 14, 2015, ... and Washington D.C. science community to the UMBC campus ... sponsored by the Protein Society, will take place from ... Room 312. Through discussion, presentations and workshops, the ... of proteins, their role in the industry and the ...
(Date:11/26/2014)... Silicon Valley Electronic Data Capture (EDC) provider ... provider of clinical research and data management services to ... its CRO Partnership Program, Clinovo expands ClinCapture , ... , “We have found Clinovo’s ClinCapture to exceed our ... is both user friendly and easy to deploy. The ...
(Date:11/26/2014)... 2014 SoundConnect , an award ... to announce that Darren Suders has joined the team ... will drive the partner program through innovative ... , Darren brings more than 10-years of channel ... in channel operations, from policy development, to partner education ...
Breaking Biology Technology:The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2SoundConnect Appoints Director of Channel Development & Sales 2
Cached News: