HOME >> BIOLOGY >> NEWS
Moving towards a cure for diabetes

Researchers from Harvard University have developed a powerful new tool in the fight against diabetes. Currently, sixteen million Americans are afflicted with diabetes; this number is expected surpass twenty-two million by the year 2025. One approach to cure diabetes is to transplant into patients stem cells that have been specifically engineered to produce endocrine hormones. As published in Genes & Development, Dr. Doug Melton and colleagues have developed a model system to evaluate which genes can effectively drive pancreatic development, and would thus be candidates for introduction into therapeutic stem cells.

Previous research into pancreas development has utilized knockout mice to determine which genes are necessary for pancreatic development. Dr. Melton and colleagues set out to determine which genes(s) are sufficient for pancreatic development. The technique they have pioneered involves the introduction of a gene of interest, or a combination of such genes, into the endoderm of live chick embryos. The region of endoderm targeted for gene introduction is not normally fated for pancreas development. Therefore, if the introduced gene(s) is sufficient to direct pancreas development, pancreatic cell differentiation will occur ectopically.

The results have been surprising. Pdx-1, a gene that has been regarded as the pancreatic master switch, was shown to be insufficient for complete pancreatic cytodifferentiation. However, Dr. Melton and colleagues did discover that the known gene regulator, NGN3, is sufficient to cause pancreatic islet differentiation and endocrine hormone expression in non-pancreatic regions of the endoderm. These results shed new light on the role of each of these genes in pancreatic development.

The in vivo experimental system that Dr. Melton and colleagues have developed represents a fundamental tool in understanding pancreatic development and determining which genes are candidates for therapeutic usage. As diabetes k
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
15-Feb-2001


Page: 1 2

Related biology news :

1. Moving targets: when it comes to patterns, motion gets factored in
2. Moving the target for osteoporosis treatment
3. Moving gene in plant results in increased production of amino acid
4. Flexible Membranes - Moving Through The Twilight Zone Between The Nano- And The Microworld
5. Moving DNA Molecules With Magnetic Tweezers
6. TANGO: towards faster prognosis of Alzheimers and Parkinsons diseases?
7. Why does cloning create abnormalities? Scientists take a step towards finding out
8. Oxford Journals takes bold step towards free access to research
9. Plants for the future: A European vision for plant biotechnology towards 2025
10. ESAs first step towards Mars Sample Return
11. First step towards detecting exposure to biowarfare agents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... ... II contract awarded by the Joint Science & Technology Office—Chemical and Biological Defense ... to develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable ...
(Date:7/22/2020)... SANTA BARBARA, Calif. (PRWEB) , ... July 21, ... ... consulting firm driving digital transformation and innovation in technology and compliance, announces a ... and medical device companies must ensure every layer of their technology stack complies ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is ... ability to discover a COVID cure or vaccine, the global economic downturn will only ... pressure is not going away and capturing full value from every product launch is ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... 2020 , ... ERT, the global leader in ... named one of the 100 most inspiring individuals in the life-sciences industry by ... based on how they have inspired their colleagues and affected positive changes in ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International ... only $3950. With 50 million stem cells total, patients may choose which extremities they ... works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, Inc. has ... be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar ... switches in a push-pull configuration; yielding fast fall time for a capacitive load. ...
(Date:7/31/2020)... and SOMERSET, N.J (PRWEB) , ... July 29, ... ... genome editing company, and Catalent, the leading global provider of advanced delivery technologies, ... health products, today announced that they have entered into a strategic partnership whereby ...
Breaking Biology Technology:
Cached News: