Moving towards a cure for diabetes

Researchers from Harvard University have developed a powerful new tool in the fight against diabetes. Currently, sixteen million Americans are afflicted with diabetes; this number is expected surpass twenty-two million by the year 2025. One approach to cure diabetes is to transplant into patients stem cells that have been specifically engineered to produce endocrine hormones. As published in Genes & Development, Dr. Doug Melton and colleagues have developed a model system to evaluate which genes can effectively drive pancreatic development, and would thus be candidates for introduction into therapeutic stem cells.

Previous research into pancreas development has utilized knockout mice to determine which genes are necessary for pancreatic development. Dr. Melton and colleagues set out to determine which genes(s) are sufficient for pancreatic development. The technique they have pioneered involves the introduction of a gene of interest, or a combination of such genes, into the endoderm of live chick embryos. The region of endoderm targeted for gene introduction is not normally fated for pancreas development. Therefore, if the introduced gene(s) is sufficient to direct pancreas development, pancreatic cell differentiation will occur ectopically.

The results have been surprising. Pdx-1, a gene that has been regarded as the pancreatic master switch, was shown to be insufficient for complete pancreatic cytodifferentiation. However, Dr. Melton and colleagues did discover that the known gene regulator, NGN3, is sufficient to cause pancreatic islet differentiation and endocrine hormone expression in non-pancreatic regions of the endoderm. These results shed new light on the role of each of these genes in pancreatic development.

The in vivo experimental system that Dr. Melton and colleagues have developed represents a fundamental tool in understanding pancreatic development and determining which genes are candidates for therapeutic usage. As diabetes k

Contact: Nora Poppito
Cold Spring Harbor Laboratory

Page: 1 2

Related biology news :

1. Moving targets: when it comes to patterns, motion gets factored in
2. Moving the target for osteoporosis treatment
3. Moving gene in plant results in increased production of amino acid
4. Flexible Membranes - Moving Through The Twilight Zone Between The Nano- And The Microworld
5. Moving DNA Molecules With Magnetic Tweezers
6. TANGO: towards faster prognosis of Alzheimers and Parkinsons diseases?
7. Why does cloning create abnormalities? Scientists take a step towards finding out
8. Oxford Journals takes bold step towards free access to research
9. Plants for the future: A European vision for plant biotechnology towards 2025
10. ESAs first step towards Mars Sample Return
11. First step towards detecting exposure to biowarfare agents

Post Your Comments:

(Date:7/1/2020)... ... 01, 2020 , ... Catalent, a global leader in clinical ... packaging facility in Minakuchi, located in the Shiga prefecture of Japan. , Operating ... the new 60,000-square-foot facility will provide customers with flexible clinical supply solutions, serving ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... for biopharmaceutical R&D, today announced that it has entered into a multi-year ... antibodies (Multiclonics®), to support their translational and clinical research strategy to discover ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC ... services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ... patients with severe COVID-19. This is the first study of an XPO1 inhibitor ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter maintenance and ... successful study, while protecting and accessing the catheter or device post-surgery is often undervalued ... Envigo in a live webinar on Wednesday, August 5, 2020 at ...
(Date:7/18/2020)... ... 2020 , ... dicentra , a leading Contract Research ... is pleased to announce that Charles Galea has joined its clinical trials division ... an accomplished and results-driven sales executive with over 10 years of expertise in ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most ... used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate ... Dr MA has been using the zebrafish model to investigate the causes of ...
(Date:7/7/2020)... BOSTON (PRWEB) , ... July 06, 2020 , ... ... Innovative Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of ... Since 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples ...
Breaking Biology Technology:
Cached News: