HOME >> BIOLOGY >> NEWS
Multicomponent Malaria Vaccine Shows Promise in Laboratory Tests

A team of researchers, including grantees of the National Institute of Allergy and Infectious Diseases (NIAID), today reported positive results of research on a new, broad-based malaria vaccine. A paper describing their findings appears in the February 16 issue of the Proceedings of the National Academy of Sciences USA.

Health officials have long sought a vaccine to prevent malaria, a disease that affects 300 to 500 million people and kills up to 3 million people worldwide each year. "Improving international health is a high priority of the NIAID, and malaria research is a major area of interest," comments Anthony S. Fauci, M.D., director of the institute. "Although these results are preliminary and the candidate vaccine has yet to be tested in people, its effectiveness in laboratory tests makes it an interesting candidate for further study."

The most severe form of malaria is caused by a microscopic parasite, Plasmodium falciparum, that is transmitted to humans by mosquitoes. The parasite has a complex life cycle. Following injection into the bloodstream, it rapidly travels to the liver where it multiplies. New forms of the parasite are then released into the bloodstream where they invade red blood cells, ultimately destroying them. In their recent paper, a research team directed by Altaf A. Lal, Ph.D., of the U.S. Centers for Disease Control and Prevention (CDC), describes a new candidate vaccine that targets the malaria parasite at several stages of its life cycle.

The scientists combined segments of 21 different P. falciparum proteins to form a single recombinant protein, which they used to immunize rabbits. Each of the 21 segments, or peptides, was selected because it was recognized by the immune systems of people with malaria, as shown in earlier studies. Furthermore, the peptides targeted different branches of the immune system: B cells, helper T cells and cytotoxic T lymphocytes (CTLs).

Laboratory tests showed that the vaccine induc
'"/>

Contact: Sam Perdue
sperdue@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
16-Feb-1999


Page: 1 2

Related biology news :

1. GenVec, U.S. NMRC, and PATHs Malaria Vaccine Initiative partner to expand malaria vaccine efforts
2. Malaria rise in Africa parallels warming trends
3. Pan-African Malaria Conference November 17-22 in Arusha, Tanzania
4. Multilateral Initiative on Malaria Secretariat to move to Sweden
5. Malaria research and training benefits global community
6. Malaria called failure, puzzle and challenge
7. Christmas Travellers Are Warned Of Malaria Risks
8. Genetic Code Of Chromosome Of Malaria Parasite Deciphered
9. Virginia Tech Scientist Seek Genetic Solution To Malaria
10. Severe Falciparum Malaria Increases In Honduras
11. Curing Malaria, Controlling Mosquitoes Symposium Set For AAAS Meeting

Post Your Comments:
(Date:8/20/2015)... The wearable technology market has traditionally ... healthy. However, wearable technology has the potential to ... improve diagnostic capabilities and therapeutic outcomes. Today, Leaf ... Technologies Conference 2015 , where Barrett Larson ... healthcare.    "Over the past decade, ...
(Date:8/18/2015)... Aug. 18, 2015  Navitas today announced ... to the Submission Content Management webinar scheduled ... non-profit forum. Dedicated to the Implementation of Regulatory ... platform for industry, vendors, health authorities, consultants ... work towards a standard method of implementing ...
(Date:8/12/2015)... , August 12, 2015 ... of mobile payment innovation and advanced biometrics technology is ... the way consumers rely on using their credit cards, ... reinventing the future for payment services led by companies ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ), ...
Breaking Biology News(10 mins):Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
(Date:8/28/2015)... CA (PRWEB) , ... August 28, 2015 , ... ... in Personalized Medicine, presented two studies at the International Spine Intervention Society’ ... July 28th, 2015 through to August 1st, 2015. With a focus on evidence-based ...
(Date:8/27/2015)... CA (PRWEB) , ... August 27, 2015 , ... ... unique opportunity for venture capital funds, investment firms and animal health companies to ... Forum have raised $160 million. Several have also received licensing agreements or distribution ...
(Date:8/27/2015)... , Aug. 27, 2015  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, today announced that executives ... in the month of September.  , ... at Rodman & Renshaw,s 17th Annual Global Investment Conference ... at the St. Regis Hotel in New ...
(Date:8/27/2015)... ... 27, 2015 , ... METTLER TOLEDO's web-based EasyFinder™ ... choices to a manageable shortlist of bench and floor scales and terminals. Specifying ... best with the customer’s industry and application. , Side-by-side product comparisons and ...
Breaking Biology Technology:Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2METTLER TOLEDO Updates Online Scale Selection Tool 2
Cached News: