HOME >> BIOLOGY >> NEWS
Multicomponent Malaria Vaccine Shows Promise in Laboratory Tests

A team of researchers, including grantees of the National Institute of Allergy and Infectious Diseases (NIAID), today reported positive results of research on a new, broad-based malaria vaccine. A paper describing their findings appears in the February 16 issue of the Proceedings of the National Academy of Sciences USA.

Health officials have long sought a vaccine to prevent malaria, a disease that affects 300 to 500 million people and kills up to 3 million people worldwide each year. "Improving international health is a high priority of the NIAID, and malaria research is a major area of interest," comments Anthony S. Fauci, M.D., director of the institute. "Although these results are preliminary and the candidate vaccine has yet to be tested in people, its effectiveness in laboratory tests makes it an interesting candidate for further study."

The most severe form of malaria is caused by a microscopic parasite, Plasmodium falciparum, that is transmitted to humans by mosquitoes. The parasite has a complex life cycle. Following injection into the bloodstream, it rapidly travels to the liver where it multiplies. New forms of the parasite are then released into the bloodstream where they invade red blood cells, ultimately destroying them. In their recent paper, a research team directed by Altaf A. Lal, Ph.D., of the U.S. Centers for Disease Control and Prevention (CDC), describes a new candidate vaccine that targets the malaria parasite at several stages of its life cycle.

The scientists combined segments of 21 different P. falciparum proteins to form a single recombinant protein, which they used to immunize rabbits. Each of the 21 segments, or peptides, was selected because it was recognized by the immune systems of people with malaria, as shown in earlier studies. Furthermore, the peptides targeted different branches of the immune system: B cells, helper T cells and cytotoxic T lymphocytes (CTLs).

Laboratory tests showed that the vaccine induc
'"/>

Contact: Sam Perdue
sperdue@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
16-Feb-1999


Page: 1 2

Related biology news :

1. GenVec, U.S. NMRC, and PATHs Malaria Vaccine Initiative partner to expand malaria vaccine efforts
2. Malaria rise in Africa parallels warming trends
3. Pan-African Malaria Conference November 17-22 in Arusha, Tanzania
4. Multilateral Initiative on Malaria Secretariat to move to Sweden
5. Malaria research and training benefits global community
6. Malaria called failure, puzzle and challenge
7. Christmas Travellers Are Warned Of Malaria Risks
8. Genetic Code Of Chromosome Of Malaria Parasite Deciphered
9. Virginia Tech Scientist Seek Genetic Solution To Malaria
10. Severe Falciparum Malaria Increases In Honduras
11. Curing Malaria, Controlling Mosquitoes Symposium Set For AAAS Meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2016)... 1, 2016  Today, the first day of American ... to develop a first of its kind workplace health ... Watson. In the first application of Watson ... IBM ), and Welltok will create a new offering ... cognitive analytics, delivered on Welltok,s health optimization platform. The ...
(Date:1/25/2016)... BLUE BELL, Pa. , Jan. 25, 2016   Unisys ... facial recognition system at John F. Kennedy (JFK) International Airport, ... and Border Protection (CBP) identify imposters attempting to enter ... or do not belong to them. pilot testing ... rolled out initially at three terminals at JFK during January 2016. ...
(Date:1/21/2016)... , January 21, 2016 ... to a new market research report "Emotion Detection and ... Others), Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020", published by MarketsandMarkets, ... expected to reach USD 22.65 Billion by 2020, ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... , Feb. 3, 2016  Discovery Laboratories, ... focused on developing aerosolized KL4 surfactant therapies for ... Directors has approved an inducement award as a ... , its newly appointed President and Chief Executive ... Compensation Committee on February 1, 2016 and granted ...
(Date:2/3/2016)... 2016 New Jersey Health Foundation (NJHF) has ... for researchers in New Jersey ... demonstrates exciting potential.   James M. ... New Jersey Health Foundation Research Grant Program ... institutions— Princeton University, Rutgers University, Rowan University and ...
(Date:2/3/2016)... ... February 03, 2016 , ... Resilinc released online ... analyzes nearly 750 unique supply chain notifications and alerts generated by its ... chain risk management practitioners subscribe to the EventWatch service to receive early warnings ...
(Date:2/3/2016)... ... February 03, 2016 , ... Data Sciences ... solutions focused on social housing of small animal models in research studies. ... ² , DSI’s HD-S11 implant has evolved to allow researchers to simultaneously measure ...
Breaking Biology Technology:
Cached News: