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Multicomponent Malaria Vaccine Shows Promise in Laboratory Tests

ed a high level of antibodies that recognized the parasite at different stages of development. The antibodies also blocked P. falciparum invasion into the rabbits' liver cells and inhibited growth of the organism in their blood. Although the researchers have not yet looked at the T-cell responses in vaccinated animals, these studies are under way.

"Multicomponent vaccines may offer an advantage over single-component vaccines because they may provide multiple levels of protection against different parasite stages," says Lee Hall, M.D., Ph.D., program officer for parasite vaccine development at NIAID. "Such vaccines may also reduce the spread of vaccine-resistant strains, which can arise when a pathogen changes a surface protein to avoid detection by the immune system."

NIAID is a component of the National Institutes of Health (NIH). NIAID conducts and supports research to prevent, diagnose and treat illnesses such as HIV disease and other sexually transmitted diseases, tuberculosis, malaria, asthma and allergies. NIH is an agency of the U.S. Department of Health and Human Services.


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Contact: Sam Perdue
sperdue@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
16-Feb-1999


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