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Muscle derived cell transplants offer alternative incontinence therapy says Pitt study

tin, suggesting differentiation of the cells into smooth muscle. Researchers also observed the presence of neuromuscular junctions, indicating that the muscle was supplied with nerves giving the muscle the ability to become functional tissue.

These findings indicate that the use of MDCs may prove to be a very promising new therapy in the treatment of urinary incontinence. Essentially, we are giving the bladder muscles the ability to fix themselves by generating new muscle, said Michael Chancellor, M.D., professor of urology and gynecology at the University of Pittsburgh School of Medicine. In future studies we hope this will turn into a long lasting, if not permanent, solution for our patients.

Urinary incontinence affects 13 million Americans and is typified by the inability to control the flow of urine. Incontinence can be caused by a number of different anatomic, physiologic, and pathologic factors and can be temporary or chronic. The ability to control bladder function relies on the combined function of the smooth muscle tissue of the urethra and bladder, skeletal muscle and the nervous system.


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Contact: Jocelyn Uhl
412-647-3555
University of Pittsburgh Medical Center
25-May-2002


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