HOME >> BIOLOGY >> NEWS
Muscle gene influences fat storage in mice; may be target to prevent or treat obesity and diabetes

For mice genetically altered to get fat, knocking out a particular gene keeps them both leaner and healthier, Johns Hopkins School of Medicine scientists report in the March 1 issue of the Journal of Clinical Investigation.

That "lean" gene is the blueprint for myostatin, a protein known to limit muscle growth, they report. Previous Hopkins studies found that mice without myostatin are muscle-bound "mighty mice." Now the scientists show that mice without the protein, even mice that usually become obese, gain much less fat as they age.

"This tells me that myostatin might be a useful target for preventing or treating obesity and associated conditions, like diabetes," says Se Jin Lee, M.D., Ph.D., professor of molecular biology and genetics in the school's Institute for Basic Biomedical Sciences. "However, we've been studying genetic knock-outs; we don't know yet whether we can block myostatin in adult animals and see similar effects. In fact, myostatin-blocking agents still need to be developed."

In their experiments, Lee and postdoctoral fellow Alexandra McPherron crossed myostatin-free mice with each of two kinds of obese mice to get "doubly engineered" offspring. These second- generation mice lack myostatin and also have a genetic change that causes obesity. One line of fat mice, officially named "obese," eat excessively because they lack the hormone leptin. The other fat mice eat too much because their production of a protein called "agouti" is abnormal.

By examining amounts of fat and muscle in mice, the scientists discovered that regular and obese mice without myostatin gained less fat as they got older, even though they ate about the same amounts of food as other mice. In fact, "mighty mice" outweigh their counterparts when young, but by 10 months of age or so weighed the same or less than other mice, which had bulked up with fat.

"Some normal mice put on a lot of fat as they age and others not as much, but animal
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
27-Feb-2002


Page: 1 2 3

Related biology news :

1. Muscles are smarter than you think
2. Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
3. Muscle protein has role in nerve disorders
4. Muscle-repair defect underlies two muscular dystrophies
5. Muscle derived cell transplants offer alternative incontinence therapy says Pitt study
6. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant
7. Common Respiratory Virus Identified As One Cause Of Heart Muscle Damage That Can Lead To Sudden Death
8. Technique Measures Muscle Contraction At Molecular Level
9. Growth Factors Improve Muscle Healing In Animals
10. Skeletal Muscle Yields Precursors Of Bone Cells That Form Bone When Transplanted Into Animals
11. New Gene Therapy Strategy Keeps Muscles Strong In Old Age: Possibilities Seen For Disease Treatment, But Also For Athletic Or Cosmetic Enhancements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/12/2019)... ... 11, 2019 , ... Neal O’Farrell is one of the first generation of ... executive director of the consumer advocacy non-profit the Identity Theft Council as well as ... the Federal Communications Commission’s Cybersecurity Roundtable and is currently a fellow of the EP3 ...
(Date:4/9/2019)... ... April 09, 2019 , ... The McLeod Center for Cancer Treatment and ... rigorous and voluntary audit conducted by an independent, third-party panel of experts in radiation ... in the United States, McLeod is the only such cancer center in South Carolina. ...
(Date:4/4/2019)... ... April 02, 2019 , ... The live session ... into the connectivity between product risk management (ISO 14971) and the clinical risk ... process. , With increasing global regulation and reimbursement challenges faced by medical device ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... March 19, 2019 , ... Konica Minolta Precision Medicine, Inc. ... of their inaugural Scientific Advisory Board. , Founded in late 2018, ... individual variability in genes, environment, and lifestyle to more accurately predict, detect, treat ...
(Date:3/18/2019)... ... March 18, 2019 , ... For more than 15 years, USDM ... allow life science companies to easily comply with FDA 21 CFR Part 11 and ... a managed service delivering end-to-end GxP compliance from vendor audit through ongoing validation maintenance, ...
(Date:3/14/2019)... ... March 14, 2019 , ... Open registration for the ... Full Spectrum of Case Management,” continues as CMSA makes plans to host the ... only case management industry conference serving the educational and networking needs of case ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... standard solution for preclinical research organizations. It is a low code, GDPR/21 ... systems and facilities, innovative technology-driven automated data capture and seamless data and ...
Breaking Biology Technology:
Cached News: