HOME >> BIOLOGY >> NEWS
Muscle protein has role in nerve disorders

A protein that plays a role in muscular dystrophies also may be involved in peripheral neuropathy disorders of the nerves that carry messages between the brain and the rest of the body. The findings, by University of Iowa researchers and colleagues, may shed light on the causes and mechanisms of human peripheral neuropathies, which cause pain, numbness and muscle wasting.

Peripheral neuropathies can be acquired as a result of diseases including diabetes and Hansen's disease (leprosy) or can be inherited. Some congenital peripheral neuropathies (those present at birth) can cause limb deformities. The UI study may suggest new treatment strategies for these conditions.

Kevin Campbell, Ph.D., a Howard Hughes Medical Institute investigator and UI professor and interim head of physiology and biophysics and professor of neurology, led the team investigating the role of the protein, dystroglycan, in the peripheral nervous system. The study appeared in the June 5 issue of Neuron.

In the peripheral nervous system, dystroglycan is found in Schwann cells, which wrap themselves around peripheral axons (nerve fibers) and protect them by producing a myelin sheath. The sheath allows nerve impulses to move faster and more efficiently along the nerves. If nerve fibers are the body's electrical wiring, then the myelin sheath represents the insulation.

Each Schwann cell envelops a short stretch of axon, and the gaps between each section of the myelin sheath are called nodes of Ranvier. Ions flow through sodium channels at these nodes generating action potentials or nerve impulses. This signal is transmitted down the nerve fiber from one node to the next.

The researchers found that dystroglycan is necessary to form normal myelin sheaths. They also discovered that loss of the protein disrupts the structure of the nodes of Ranvier and affects the nerve's ability to transmit nerve impulses. The results suggest that disruption of dystroglycan's func
'"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
17-Jun-2003


Page: 1 2 3

Related biology news :

1. Muscles are smarter than you think
2. Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
3. Muscle-repair defect underlies two muscular dystrophies
4. Muscle derived cell transplants offer alternative incontinence therapy says Pitt study
5. Muscle gene influences fat storage in mice; may be target to prevent or treat obesity and diabetes
6. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant
7. Common Respiratory Virus Identified As One Cause Of Heart Muscle Damage That Can Lead To Sudden Death
8. Technique Measures Muscle Contraction At Molecular Level
9. Growth Factors Improve Muscle Healing In Animals
10. Skeletal Muscle Yields Precursors Of Bone Cells That Form Bone When Transplanted Into Animals
11. New Gene Therapy Strategy Keeps Muscles Strong In Old Age: Possibilities Seen For Disease Treatment, But Also For Athletic Or Cosmetic Enhancements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... 2020 , ... Today CJ BIO announced the first in a series of ... taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a ... July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a registered 501(c)(3) ... and aggressive adult brain cancer—announced today the appointments of its first Senior Fellows: ... supporting the organization’s initiatives and overall vision. , "Senior Fellows are more than ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative ... to support testing operations in the fight against the COVID-19 pandemic in Zambia. ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... reliable, solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, ... controller that can drive one or two switches in a push-pull configuration; yielding ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. (Nasdaq: ... advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene ... strategic partnership whereby Catalent will provide support for the development, manufacturing, and clinical ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory ... 16 countries, has reached its 20th anniversary of worldwide use. Introduced in the ... top universities including University of Pennsylvania, University of Michigan, University of Maryland, University ...
(Date:7/22/2020)... TORONTO (PRWEB) , ... July 22, 2020 , ... Join ... and John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... is the regulating body in China for drugs and medical devices. Specifically, for medical ...
Breaking Biology Technology:
Cached News: