HOME >> BIOLOGY >> NEWS
Muscle protein has role in nerve disorders

A protein that plays a role in muscular dystrophies also may be involved in peripheral neuropathy disorders of the nerves that carry messages between the brain and the rest of the body. The findings, by University of Iowa researchers and colleagues, may shed light on the causes and mechanisms of human peripheral neuropathies, which cause pain, numbness and muscle wasting.

Peripheral neuropathies can be acquired as a result of diseases including diabetes and Hansen's disease (leprosy) or can be inherited. Some congenital peripheral neuropathies (those present at birth) can cause limb deformities. The UI study may suggest new treatment strategies for these conditions.

Kevin Campbell, Ph.D., a Howard Hughes Medical Institute investigator and UI professor and interim head of physiology and biophysics and professor of neurology, led the team investigating the role of the protein, dystroglycan, in the peripheral nervous system. The study appeared in the June 5 issue of Neuron.

In the peripheral nervous system, dystroglycan is found in Schwann cells, which wrap themselves around peripheral axons (nerve fibers) and protect them by producing a myelin sheath. The sheath allows nerve impulses to move faster and more efficiently along the nerves. If nerve fibers are the body's electrical wiring, then the myelin sheath represents the insulation.

Each Schwann cell envelops a short stretch of axon, and the gaps between each section of the myelin sheath are called nodes of Ranvier. Ions flow through sodium channels at these nodes generating action potentials or nerve impulses. This signal is transmitted down the nerve fiber from one node to the next.

The researchers found that dystroglycan is necessary to form normal myelin sheaths. They also discovered that loss of the protein disrupts the structure of the nodes of Ranvier and affects the nerve's ability to transmit nerve impulses. The results suggest that disruption of dystroglycan's func
'"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
17-Jun-2003


Page: 1 2 3

Related biology news :

1. Muscles are smarter than you think
2. Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
3. Muscle-repair defect underlies two muscular dystrophies
4. Muscle derived cell transplants offer alternative incontinence therapy says Pitt study
5. Muscle gene influences fat storage in mice; may be target to prevent or treat obesity and diabetes
6. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant
7. Common Respiratory Virus Identified As One Cause Of Heart Muscle Damage That Can Lead To Sudden Death
8. Technique Measures Muscle Contraction At Molecular Level
9. Growth Factors Improve Muscle Healing In Animals
10. Skeletal Muscle Yields Precursors Of Bone Cells That Form Bone When Transplanted Into Animals
11. New Gene Therapy Strategy Keeps Muscles Strong In Old Age: Possibilities Seen For Disease Treatment, But Also For Athletic Or Cosmetic Enhancements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their boarding ... ... biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at the ... to allow eligible Delta SkyMiles Members who are enrolled in CLEAR to ...
(Date:5/23/2017)... robotic gym for the rehabilitation and functional motor sense evaluation of lower ... . The first 30 robots will be available from June in ... The technology was developed and patented at the IIT laboratories and has ... to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... At its ... Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has ... was a member of the winning team for the 2015 Breakthrough Prize in Fundamental ...
(Date:10/7/2017)... Arizona (PRWEB) , ... October ... ... 15 years’ experience providing advanced instruments and applications consulting for microscopy and ... in-house expertise in application consulting, Nanoscience Analytical offers a broad range of ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... the healthcare and technology sector at their fourth annual Conference where founders, investors, ... inspiring speakers and the ELEVATE pitch competition showcasing early stage digital health and ...
(Date:10/5/2017)... ... October 05, 2017 , ... Understanding the microbiome, the millions of bacteria that ... Love: You Are My Future, the newest exhibit on display at the University City ... human condition through the lens of the gut microbiome. , Gut Love opens ...
Breaking Biology Technology:
Cached News: