HOME >> BIOLOGY >> NEWS
Mutant mice lead to memory insights

Two strains of mutant mice with crippled versions of a key memory molecule have led researchers to an understanding of both normal memory function and the memory problems that plague sufferers of an inherited disorder.

The researchers said their findings suggest that drugs already being tested for cancer and Huntington's disease might be useful in restoring some memory capability to patients with Rubinstein-Taybi syndrome (RTS). RTS is a heritable disorder characterized by mental and growth retardation and skeletal abnormalities. In humans, RTS occurs in about one in 125,000 births. The researchers propose that their findings could lead to treatments for RTS and other memory disorders as well as a means of improving memory in otherwise healthy individuals.

Two groups of researchers independently studied mutant mice deficient in "CREB binding protein" (CBP), which is a common target in patients with RTS. CBP is so named because it binds a key gene-regulating protein called CREB that is important for many functions including memory in animals from mollusks to humans.

CBP is a particularly hard-working protein. It serves as a molecular scaffold that helps assemble the machinery of gene transcription known to be necessary for formation of long-term memories. And critically, CBP acts as an enzyme that transfers acetyl groups onto the histone proteins that are part of the chromatin enfolding DNA in the chromosomes. Such acetylation is a central process in remodeling the chromatin to prepare the chromosome for gene transcription.

In one paper, Eric Kandel and his colleagues studied a mutant mouse -- developed in another laboratory -- in which one of the two copies of the gene for CBP had been knocked out. Such "haploinsufficiency" is thought to be a good animal model for Rubinstein-Taybi syndrome, because it mimics many of the symptoms of the disease.

In their studies, the researchers sought to understand whether such haploinsuffi
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
23-Jun-2004


Page: 1 2 3

Related biology news :

1. Mutant biological machine makes proteins but cant let go
2. Mutant gene linked to obsessive compulsive disorder
3. Mutant gene found to cause early ovarian failure in mice
4. Mutants from a lowly weed may solve maladies
5. Mutant proteins may be key to defeat chemical warfare
6. Protein Misfolding, Not Mutant Gene, Key To Lethal Sleep Disorder
7. Mechanism Discovered For Determining Early Vertebrate Body Plan: New Zebrafish Mutants Afford Deeper Look Into Embryonic Patterning
8. MITs Mini Respirator Breathes Life Into Mutant Mice
9. Induced Mutant Mouse Models Of Lipoprotein Disorders And Atherosclerosis
10. Mutant Gene Not Sole Explanation For Hiv Non-Progression
11. Single Mechanism Seen To Underlie Group Of Neurodegenerative Diseases: Mutant Proteins Form Insoluble Masses In The Nuclei Of Neurons

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/9/2019)... ... November 08, 2019 , ... SiteSeer Technologies, creator of SiteSeer Professional ... new client and user of SiteSeer. The boutique real estate developer of single and ... use SiteSeer to supplement its own analysis of markets. , Geoffrey Kerth, manager ...
(Date:11/6/2019)... Mich. (PRWEB) , ... November 06, 2019 , ... ... Mastermind® version 2.0 today. The Genomic Search Engine now includes the ability ... functionality will further accelerate diagnosis of patients with genetic and rare diseases. , ...
(Date:10/30/2019)... CUMBERLAND FORESIDE, Maine (PRWEB) , ... October 29, ... ... UC4 linearity and calibration verification kits, for SIEMENS ATELLICA® analyzers, Order Numbers 701sa ... GLU, K, MG, NA, PHOS, UA, UTP, and UUN. , Each VALIDATE® kit, ...
Breaking Biology News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... ... solutions for biopharmaceutical R&D, today announced that Immatics Biotechnologies , a ... Genedata Biologics® to streamline their R&D operations related to the discovery ...
(Date:11/6/2019)... ... ... Diversified Technologies, Inc. has introduced a PEF production system for ... processing. , The DTI Industrial PEF Unit can pre-treat whole pieces of fruits and ... up to 50% and achieve up to an 80% reduction of drying energy. ...
(Date:11/2/2019)... ... October 31, 2019 , ... A ... communicating with each other: study managers, principal investigators, supply chain managers, manufacturers, IRT, ... is not informed of the latest data, potentially leading to patient risk. , ...
(Date:10/29/2019)... ... ... CaroGen Corporation , a biotechnology company, today announced three distinguished additions to ... MD, of Brown University , Dr. Steve Projan, PhD, FAAM, formerly of ... Wayne State University, formerly a professor at Yale University School of Medicine ...
Breaking Biology Technology:
Cached News: