HOME >> BIOLOGY >> NEWS
Mutation may help cause acute myeloid leukemia

ed to inhibit aml1-eto and tyrosine kinase receptors might one day be used to control this disease."

Tyrosine kinases power chemical reactions in cells, particularly those involved in cell division. Normally, these molecules are carefully regulated to keep a tight lid on cell growth. But they can lose that regulation when tyrosine kinase genes mutate. Instead of powering reactions only when appropriate, for example, the tel-pdgfrb protein runs constantly, like an engine that won't shut off.

"Mutations in tyrosine kinases can push cells to divide," says Grisolano. "If this is combined with a mutation that blocks cells from maturing, as does the aml1-eto gene, it can lead to cancer."

For example, mutations in a gene known as flt3 (pronounced flit 3), also in the tyrosine-kinase gene family, are among the most common mutations in people with AML. Drugs that block flt3 are being developed as a possible treatment for AML. Tel-pdgfrb is closely related to flt3.

"This study further supports the idea that tyrosine kinases may be highly worthwhile targets for new drugs to treat AML," says Tomasson.


'"/>

Contact: Darrell E. Ward
wardd@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
1-Aug-2003


Page: 1 2

Related biology news :

1. Mutation causes specific arrhythmia and sudden cardiac death
2. Mutation in DKC1 gene can cause rare aging disease and cancer
3. Mutations may yield clues to heartbreaking childhood disease
4. Mutations in the ABCR gene are an overwhelming cause of inherited vision loss
5. Mutations not the only gene defect that leads to cancer
6. Mutation on Y chromosome stops sperm production
7. Mutation in PTEN gene can cause cancer and autoimmune disease
8. Emory University Scientists Demonstrate New Pathway For Genetic Mutations In Everyday Cell Life
9. Genetic Mutations Linked To Rare Metabolic Disease
10. Researchers Discover Genetic Mutation For Rare Form Of Dwarfism
11. Discovery Of Mutation May Lead To Help For Male Fertility Problems

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mutation may help cause acute myeloid leukemia

(Date:3/23/2015)... --  HOYOS Labs , a leading global authentication infrastructure ... Company will demonstrate multiple biometrics-based technologies under its identity ... on March 23 through 25, 2015, in ... IEEE Biometric Open Protocol Standard; free biometrics-based consumer app, ... system. BOPS was invented by HOYOS Labs and contributed ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report to ... for Hand Geometry in US$ Thousands. The report provides separate ... Japan , Europe , ... , and Rest of World. Annual estimates and ...
(Date:3/18/2015)... 2015 As mobile payments become more ... wallets and apps continue to be introduced into the market ... mobile payment industry in focus today are:  NXT-ID, Inc. (NASDAQ: ... BABA ), Apple Inc. (NASDAQ: AAPL ), ... (NASDAQ: FB ) NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
(Date:3/30/2015)... San Francisco, CA (PRWEB) March 30, 2015 ... and tax incentives provided you the government, major companies ... state and local governments setting future mandates for renewable ... power as an option. , Solara Power is a ... to several incentive programs available that allow qualifying homeowners ...
(Date:3/30/2015)...  New Jersey Health Foundation, a not-for-profit organization that ... New Jersey , has committed $1 ... James M. Golubieski , president. Through ... an additional $500,000 will be available for awards of ... projects that demonstrate exciting potential and may lead to ...
(Date:3/30/2015)... 30, 2015  Spherix Incorporated (Nasdaq: SPEX ... fostering and monetization of intellectual property, today provided ... 3:13-cv-03494-M and  Spherix v. Uniden , Case No. ... for the Northern District of Texas ... v. Verizon, Case No. 1:14-cv-00721-GBL-TCB, in the ...
(Date:3/30/2015)... MADISON, Wis. , March 30, 2015 /PRNewswire/ ... 4901) ("Fujifilm") and Cellular Dynamics International, Inc. (CEO: ... a leading developer and manufacturer of fully functioning human ... that the two companies have entered into a definitive ... tender offer to be followed by a second step ...
Breaking Biology Technology:Solara Power Announces Residential Solar Power with No Up-Front Fees 2New Jersey Health Foundation Announces An Additional $1 Million To Fund Innovation and Research Grants in New Jersey 2Spherix Provides Update on Litigation vs. VTech, Uniden and Verizon 2Spherix Provides Update on Litigation vs. VTech, Uniden and Verizon 3Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 2Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 3Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 4Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 5Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 6Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 7Fujifilm Holdings to Acquire Cellular Dynamics International, Inc. 8
Cached News: