HOME >> BIOLOGY >> NEWS
Mutation on Y chromosome stops sperm production

December 1, 1999 - After an arduous search, Howard Hughes Medical Institute (HHMI) investigator David Page has found the first mutation on the Y chromosome that prevents sperm production and thus causes male infertility. The finding, described in the December issue of the journal Nature Genetics, may eventually help in the design of male contraceptives and treatments for infertile males.

"It's been very difficult to find the smoking gun - the definitive evidence that any particular gene is the cause of male infertility," said Page, whose laboratory is at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology. "Of course this is only one case so we have certainly not solved a public health problem. But at least it's a first instance where we can provide an explanation."

Researchers have uncovered the genetic causes for a flood of diseases as more DNA data have become available. But the study of infertility has lagged. "The very idea that infertility could be genetic seemed not all that logical," said Page. "Most people didn't get beyond the idea of what genetics is - the study of disease passed on in families - and the definition of infertility - the inability to have families."

Genetics and infertility can coexist, however. The impact of an infertility mutation can be hidden, for example, depending on the identity of other genes present in an individual. Thus it is important to see if signs of male infertility, such as a low sperm count, coincide in related individuals such as brothers and uncles.

For now only about 20 percent of cases of male infertility can be traced either to the loss of a large chunk of the male Y chromosome, or to some other large chromosome abnormality, such as the presence of a second X chromosomes in a male. Normal males have an X and a Y chromosome, whereas females have two X chromosomes.

Page wanted to see which gene within one of the large missing Y chromosome chunks was
'"/>

Contact: Joseph Alper
alperj@hhmi.org
720-890-1956
Howard Hughes Medical Institute
29-Nov-1999


Page: 1 2 3

Related biology news :

1. Mutation may help cause acute myeloid leukemia
2. Mutation causes specific arrhythmia and sudden cardiac death
3. Mutation in DKC1 gene can cause rare aging disease and cancer
4. Mutations may yield clues to heartbreaking childhood disease
5. Mutations in the ABCR gene are an overwhelming cause of inherited vision loss
6. Mutations not the only gene defect that leads to cancer
7. Mutation in PTEN gene can cause cancer and autoimmune disease
8. Emory University Scientists Demonstrate New Pathway For Genetic Mutations In Everyday Cell Life
9. Genetic Mutations Linked To Rare Metabolic Disease
10. Researchers Discover Genetic Mutation For Rare Form Of Dwarfism
11. Discovery Of Mutation May Lead To Help For Male Fertility Problems

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... India , December 7, 2016 According to a ... Machine Learning), Software Tool (Facial Expression, Voice Recognition), Service, Application Area, End User, ... is estimated to grow from USD 6.72 Billion in 2016 to USD 36.07 ... Continue Reading ... ...
(Date:12/7/2016)...   Veridium , a leader in biometrics-based ... CEO James Stickland . Stickland, a seasoned ... has served in senior executive roles for HSBC, ... expanding a pipeline of venture capital and accelerating ... served as managing director of U.K.-based fintech firm ...
(Date:12/6/2016)... , Dec. 6, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... announced today a five (5) year funding commitment ... to expand the rehabilitation and reentry support to ... History Established in 2004, the Prison Entrepreneurship Program ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... Linda, Ca (PRWEB) , ... ... ... for low-cost, disposable devices with short response times capable of performing routine ... food fields, disposable screen-printed electrodes provide fast, sensitive detection and quantification of ...
(Date:1/12/2017)... ... January 12, 2017 , ... After her ... Rosendahl’s doctors gave her only a few months to live. Now a paper ... has stabilized Rosendahl’s disease and increased both the quantity and quality of her ...
(Date:1/12/2017)... 2017   Protein Sciences Corporation , a ... Flublok Influenza Vaccine ®, announced today that its ... safety results and induced strong neutralizing antibodies against ... is expected to advance into human clinical trials ... Institute of Technology in Immunobiologicals of the Oswaldo ...
(Date:1/12/2017)... The report "Direct-Fed Microbials Market by Type (Lactic Acid Bacteria and Bacillus), Livestock (Pork/Swine, ... Forecast to 2022", published by MarketsandMarkets, the global market is estimated to be ... Million by 2022, at a CAGR of 6.96% from 2016. ... ... Logo ...
Breaking Biology Technology:
Cached News: