Mystery Of Vital Cell Protein Solved After 30 Years

BERKELEY, CA. -- A 30-year quest to solve the structure of one of the most important types of proteins in a living cell has been achieved. Scientists with the U.S. Department of Energy's Lawrence Berkeley National Laboratory have created the first 3-dimensional atomic model of tubulin, a protein that makes possible such vital life processes as cell division and the movement of materials within cells.

Eva Nogales, Sharon Wolf, and Kenneth Downing, biophysicists with Berkeley Lab's Life Sciences Division, announced the completion of their model in the January 8, 1998 issue of the scientific journal Nature. At a resolution of 3.7 angstroms, the model provides the first highly-detailed three-dimensional look at tubulin, including the site where the protein interacts with the promising anti-cancer drug taxol.

Tubulin is the protein that polymerizes into long chains or filaments that form microtubules, hollow fibers which serve as a skeletal system for living cells. Microtubules have the ability to shift through various formations which is what enables a cell to undergo mitosis or to regulate intracellular transport. The formation-shifting of microtubules is made possible by the flexibility of tubulin which is why scientists have sought to understand the protein's atomic structure since its discovery in the 1950s.

Interest in tubulin structure heated up intensely in recent years when taxol, a natural substance found in the bark of the Pacific yew tree (the name "taxol" has been trademarked by Bristol-Myers-Squibb), was shown in clinical tests to be an effective treatment for a number of cancers including ovarian, breast, and lung. Cancer occurs when cell division runs amok.

By binding to tubulin and causing the protein to lose its flexibility, taxol prevents a cell from dividing. With better knowledge of tubulin structure and its interaction with taxol, scientists believe that an even more effective anti-cancer drug, one

Contact: Lynn Yarris
DOE/Lawrence Berkeley National Laboratory

Page: 1 2 3

Related biology news :

1. Physicists Find Simple Solution To Great-And-Small Mystery
2. CU Research Team Unravels Mystery Of Larceny Among Tropical Ant Species
3. Salmon Syndrome M74: Cause Still A Mystery
4. Light Shed On Mystery Horse Disease
5. Symposium Explores Neandertal Question, Mystery Of Human Origins
6. Understanding The Mystery Of Anesthesia
7. Scientists Unlock Mystery Behind Proteins That Keep Tuberculosis Bacteria Alive; Finding Leads To Research Into New Drug Treatments
8. Estuaries Vital To The Productivity Of Southeastern U.S. Fisheries
9. Protein is key to fatal disorder and normal cell function
10. Protein is key for digestive function of the pancreas
11. Proteins show promise for mosquito control

Post Your Comments:

(Date:6/25/2020)... ... 2020 , ... eClinical Solutions LLC , a leading ... drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) on randomized ... COVID-19. This is the first study of an XPO1 inhibitor in patients with ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, a Scottish ... supplier and manufacturer of innovative portable renewable energy equipment, have announced the success ... the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable solar ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku ... the next event in a series of TOPIQ webinars, which will cover the ... webinars was developed in response to social distancing measures that resulted in postponements ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign ... detection and prevention of high-burden diseases, and Centric Consulting, a business and technology ... to utilize existing data in order to identify and prioritize patients for care. ...
(Date:7/10/2020)... ... July 09, 2020 , ... In ... commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to ... by Dr MA has been using the zebrafish model to investigate the causes ...
(Date:7/1/2020)... ... 29, 2020 , ... MedShift , a leading medical ... many obstacles created as a result of COVID-19. As a provider at the ... practices and medical manufacturers by expanding access to device offerings, technology services, and ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 ... or drug treatment. In an effort to better understand the cellular responses to ... largest imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced ...
Breaking Biology Technology:
Cached News: