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NHGRI adds 18 organisms to sequencing pipeline

ommunity. Each of the working groups was responsible for developing a proposal for a set of genomes to sequence that would advance knowledge in one of two important scientific areas: understanding the human genome and understanding the evolutionary biology of genomes. A coordinating committee then reviewed the working groups' proposals, helping to fine-tune the suggestions and integrate them into an overarching set of scientific priorities. The recommendations of the coordinating committee were then reviewed and approved by NACHGR, which in turn forwarded its recommendations regarding sequencing strategy to NHGRI leadership.

During the working groups' deliberations, NHGRI also established an analysis group to help determine the optimal number of species and/or depth of sequence coverage for identifying conserved genome sequences. The analysis group's work will be ongoing, and the participants will continue to evaluate the new sequence data as they are generated to assess how NHGRI's strategy is working and to make any necessary adjustments to the scientific plan.

"Over the past few years, comparative analysis has emerged as an extremely powerful tool for deciphering the human genome sequence. Now, with the data generated by our more systematic approach to selecting sequencing targets, researchers can look forward to using that tool with greater precision and efficiency," said Jane Peterson, Ph.D., associate director of NHGRI's Division of Extramural Research.

In addition to the human and chimpanzee, the genomes of a number of organisms have been or are being sequenced by the large-scale sequencing capacity developed by the Human Genome Project. These include the dog, the mouse, the rat, the chicken, the honey bee, two fruit flies, the sea urchin, two puffer fish, two sea squirts, two roundworms, several fungi, baker's yeast and many prokaryotes (bacteria and archaea) including Escherichia coli. Addi
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Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
4-Aug-2004


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