HOME >> BIOLOGY >> NEWS
NICHD Researchers Discover Gene For Major Brain Structure

Researchers at the National Institute of Child Health and Human Development (NICHD) have discovered a gene that controls the development of the hippocampus, a brain structure crucial for learning and memory. The work was performed by Yangu Zhao, Ph.D., and his colleagues, of NICHD's Laboratory of Mammalian Genes and Development, led by Heiner Westphal, M.D., chief of the laboratory. The finding appears in the May 14th issue of Science.

"This work describes the function of a gene that controls the assembly of a brain structure crucial for high order mental functions," said NICHD Director Duane Alexander, M.D. "The discovery provides crucial insight into understanding the complex molecular basis of hippocampus development. Efforts of this nature may one day lead to treatments of hereditary brain disorders that affect the hippocampus."

The gene, termed Lhx5, is a member of the family of genes known as the LIM Homeobox genes, noted Dr. Westphal. Homeobox genes have changed little during the course of evolution and seem to fulfill similar functions, from roundworm to man. Essentially, these genes pave the way for developing embryo cells to later form organs and tissues.

To conduct their experiment, the researchers used a procedure known as gene knockout to inactivate the Lhx5 gene in the mouse, Dr. Westphal explained. They found that embryos lacking Lhx5 function developed a malformed hippocampus.

For this brain structure to develop normally, cells must first migrate to the correct position in the developing brain and then form the precisely ordered tissue layers of the hippocampus. In the Lhx5 knockout embryos, cells failed to migrate normally, and this resulted in a grossly distorted structure in which regular cell layers could no longer be recognized. Dr. Westphal said the layers in the normal hippocampus are analogous to patterns in the layers, or strata, seen in exposed rock formations.

"The m
'"/>

Contact: Robert Bock
rb96a@nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
14-May-1999


Page: 1 2

Related biology news :

1. NICHD funded researchers first to genetically modify non human primate
2. Researchers determine genetic cause of Timothy syndrome
3. Researchers find color sensitive atomic switch in bacteria
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Researchers develop fast track way to discover how cells are regulated
9. Researchers identify distinctive signature for metastatic prostate cancer
10. Researchers report new gene test for isolated cleft lip and palate
11. Researchers discover why mutant gene causes colon cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... partners with the pharmaceutical and biotechnology industries to improve patient outcomes and quality ... Several trends in analytical testing are being attributed to new regulatory requirements for ...
(Date:10/11/2017)... ... , ... Personal eye wash is a basic first aid supply for any work environment, but ... do you rinse first if a dangerous substance enters both eyes? It’s one less decision, ... its unique dual eye piece. , “Whether its dirt and debris, or an acid or ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , ... of Cancer Research, London (ICR) and ... with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple ... as MUK nine . The University of ... is partly funded by Myeloma UK, and ICR will perform ...
(Date:10/10/2017)... ... 10, 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, ... The bold new look is part of a transformation to increase awareness, appeal ... growth period. , It will also expand its service offering from its signature gourmet ...
Breaking Biology Technology:
Cached News: