HOME >> BIOLOGY >> NEWS
NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility

Researchers at the National Institute of Environmental Health Sciences and the University of California at Davis report that one of the body's approximately 70,000 proteins, called fertilin-beta, is essential for bringing together sperm and egg for fertilization. The research team, led by Chunghee Cho of UC-Davis, presented findings that will be a milestone in understanding how a new life begins.

The researchers believe this finding can pave the way for a non-hormonal approach to family planning and the diagnosis and treatment of some types of infertility.

Twenty years of work by the UC-Davis investigators established that fertilin-beta plays an important role in fusion of the sperm to the egg in fertilization. In this latest study, a collaboration with NIEHS scientists, mice were produced with a knockout of the fertilin-beta gene. The investigators were not surprised that sperm from these mice were unable to fuse with eggs. However, they did not expect to find that the sperm could not travel up the oviduct or bind to the zona pellucida, the envelope surrounding the egg.

The study, which appears in the journal Science, Vol. 281, pp. 1857-1859, was authored by Chunghee Cho, Ph.D.; Paul Primakoff, Ph.D.; and Diana G. Myles, Ph.D., all of University of California, Davis; and Eugenia H. Goulding; Edward M. Eddy, Ph.D.; and Donna O'Dell Bunch, Ph.D., of the Laboratory of Reproductive and Developmental Toxicology, NIEHS; and Jean-Emmanuel Faure, Ph.D., Ecole Normale Superieure de Lyon, Lyon, France.

Dr. Cho, first author on the paper, said that "astronomers study the Big Bang, the moment when the Universe began. In life, sperm-egg fusion is the Big Bang and we now understand more about the few seconds before and few seconds after this event" said Dr. Cho. "With all the current concerns about the possible effects of endocrine disruptors on fertility and of hormone-based contraceptives on the development of so
'"/>

Contact: Tom Hawkins
hawkins@niehs.nih.gov
(919) 541-1402
NIH/National Institute of Environmental Health Sciences
30-Sep-1998


Page: 1 2

Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. NIEHS and UNC to collaborate on registry of 20,000 subjects
3. NIEHS-funded researchers find low-level ozone increases respiratory risk of asthmatic children
4. NIEHS study identifies gene for hydrocephalus in mice
5. NIEHS, NTP director receives honorary doctorate
6. Advisory panel on federal report on carcinogens makes recommendations to NIEHS/NTP for new listings
7. NIEHS urges safety workers to prepare for Y2K false alarms and malfunctions
8. NIEHS-cloned gene linked to a natural substance that reduces vascular inflammation, a key to arterial clogging
9. NIEHS Finds Protein That Counteracts Inflammation And Wasting That May Target Rheumatoid Arthritis And Crohns Disease
10. Three-Way Gene-Gene-Environmental Exposure Interaction Shown By NIEHS To Escalate Smoking-Related Bladder Cancer
11. Controversial UK badger killings analyzed by UC Davis expert

Post Your Comments:
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... revenues for Q1 2015 attributed to somewhat higher than ... company in the year-end report 2014 that revenues for ... MSEK that the company reported for Q4 2014. The ... continue to be negative. The complete interim report will ...
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
(Date:3/31/2015)... , March 31, 2015  Elephant Talk Communications Corp. ... global provider of Software Defined Network Architecture (ET Software ... total revenue of approximately $20.4 million for the year ... $19.5 million for the year ended December 31, 2013. ... the Company had completed its multi-year transition away from ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
(Date:4/28/2015)... More than 50% of patients with ... over the course of their disease, and clinicians are ... the disease progresses. ReachMD , the 24/7 health ... a series dedicated to PD psychosis, featuring interviews and ... and psychiatric conditions. , The new series titled ...
(Date:4/28/2015)... Tampa, Florida (PRWEB) April 28, 2015 ... and impressions as a leading source for advice to ... success in providing consulting and strategic planning to start-ups ... to better serve the industry. , Wall Street ... First Harvest Financial as President and Portfolio Manager. ...
(Date:4/28/2015)... April 28, 2015 Reproductive endocrinologist Dr. ... in 7 couples battling infertility in this country, testified on ... Texas as the first state in the nation to consider ... embryos to couples who desire to receive them. , Infertility ... fact that infertility is one of the few medical diseases ...
(Date:4/27/2015)... VANCOUVER , April 27, 2015 /PRNewswire/ - iCo ... ICOTF), today reported financial results for the year ... are expressed in Canadian dollars and presented under ... year,s phase two DME results did not provide ... but extremely undervalued assets remain at iCo Therapeutics", ...
Breaking Biology Technology:ReachMD Launches Series Focusing on Parkinson’s Disease Psychosis 2Leading Medical Cannabis Advisor, First Harvest Financial, Welcomes Top Executives Aboard 2Leading Medical Cannabis Advisor, First Harvest Financial, Welcomes Top Executives Aboard 3Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 2Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 3iCo Therapeutics Announces Year End 2014 Financial Results 2iCo Therapeutics Announces Year End 2014 Financial Results 3iCo Therapeutics Announces Year End 2014 Financial Results 4
Cached News: