HOME >> BIOLOGY >> NEWS
NIEHS Finds Protein That Counteracts Inflammation And Wasting That May Target,,Rheumatoid Arthritis And Crohn's Disease

Scientists at NIEHS have identified a protein which may help in the quest for drugs to fight inflammatory diseases including rheumatoid arthritis, Crohn's disease, physical wasting, and graft-versus-host disease. The protein may help counteract the ill effects when the body produces excessive amounts of another protein key to fighting infection.

In proper balance, a bodily protein called tumor necrosis factor alpha performs like a hero, helping to fight infections and other bodily invaders. But like a hero gone awry, excessive TNF production stimulated by TNF itself can cause a host of inflammatory ills, such as those mentioned above, and the physical wasting that accompanies many cancers and AIDS.

Now, however, scientists at the National Institute of Environmental Health Sciences have identified a protein that can put the brakes on TNF.

Using genetically modified mice with a specific gene removed, researchers at the National Institute of Environmental Health Sciences have identified a protein that counters TNF, that in turn may lead to drugs that will curb TNF's ravages. This protein is called Tristetraprolin, or TTP.

In previous experiments, the researchers found that mice genetically modified to remove the TTP gene suffer many ailments similar to those associated with overproduction of TNF in people; yet when TNF is controlled in the mice, most of the TNF-induced problems do not develop. In their new study, published in Science (Vol. 281, p. 1001), the researchers found that this overproduction of TNF in the TTP deficient mice was due to the absence of TTP's controlling effect on TNF's synthesis by inflammatory cells.

Authors of the study are Ester Carballo, M.D., Ph.D., and Wi S. Lai, Ph.D., both of the Laboratory of Signal Transduction, NIEHS, and Perry J. Blackshear, M.D., D.Phil., Director of Clinical Research, NIEHS.

Dr. Blackshear said that TTP appears to regulate production
'"/>

Contact: Tom Hawkins
hawkins@niehs.nih.gov
(919) 541-1402
NIH/National Institute of Environmental Health Sciences
9-Sep-1998


Page: 1 2

Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. NIEHS and UNC to collaborate on registry of 20,000 subjects
3. NIEHS-funded researchers find low-level ozone increases respiratory risk of asthmatic children
4. NIEHS study identifies gene for hydrocephalus in mice
5. NIEHS, NTP director receives honorary doctorate
6. Advisory panel on federal report on carcinogens makes recommendations to NIEHS/NTP for new listings
7. NIEHS urges safety workers to prepare for Y2K false alarms and malfunctions
8. NIEHS-cloned gene linked to a natural substance that reduces vascular inflammation, a key to arterial clogging
9. NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility
10. Three-Way Gene-Gene-Environmental Exposure Interaction Shown By NIEHS To Escalate Smoking-Related Bladder Cancer
11. Very-Low-Fat Diet May Compromise Immune Function, Increase Infection Risk In Trained Runners, UB Study Finds

Post Your Comments:
(Date:10/30/2014)... A UT Arlington bioengineering professor has received a ... aims to regenerate cartilage tissue and reduce osteoarthritis ... the injection of microscaffolding made of biodegradable polymers., ... of the bioengineering department, said the research is ... injured on the battlefield., "We,ve found that if ...
(Date:10/30/2014)... North Carolina State University researchers have developed a suite ... between dogs and humans, which has applications in everything ... our pets. , "We,ve developed a platform for computer-mediated ... to new avenues for interpreting dogs, behavioral signals and ... Dr. David Roberts, an assistant professor of computer science ...
(Date:10/29/2014)... study of its kind to date, researchers have used ... the risk for autism. Joseph Buxbaum, Ph.D., Icahn School ... Daly, Ph.D., Broad Institute of Harvard and MIT, and ... affected children, parents and unrelated people. They identified changes ... the risk for autism spectrum disorder (ASD) – a ...
Breaking Biology News(10 mins):UTA researcher uses microscaffolding injections to mend cartilage, prevent osteoarthritis 2New tech aims to improve communication between dogs and humans 2
(Date:10/30/2014)... October 29, 2014 Global polyvinyl chloride ... world economic crisis during 2008-2009, especially in North America ... and currently is keeping to a growing trend. , ... is utilized in the construction segment. In 2013, the ... profiles, tubing, sheets and rigid film. Moreover, the PVC ...
(Date:10/30/2014)... James Sherley says he has been working towards ... since his days as a principal investigator at the Fox ... Sherley founded the ASCTC as a new Boston biotech ... property developed in Sherley’s research over the years since FCCC, ... (MIT), and more recently as a senior scientist at the ...
(Date:10/30/2014)... Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ), the leader ... company overview at the Nomura Biotechnology Conference on Thursday, November ... MA. A live webcast of the ... of the Company,s website, www.isispharm.com .  A replay will ... will be archived for a limited time. About ...
(Date:10/27/2014)... Ryan Carfley , Managing Partner at ... with Bryan Hamilton, the publisher of the Triangle Business Journal, ... the Research Triangle region of North Carolina. , Just a ... roundtable include the role of social media in recruitment, ... and the unique role that Millennials play in the workplace ...
Breaking Biology Technology:Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3
Cached News: