HOME >> BIOLOGY >> NEWS
NIEHS Finds Protein That Counteracts Inflammation And Wasting That May Target,,Rheumatoid Arthritis And Crohn's Disease

Scientists at NIEHS have identified a protein which may help in the quest for drugs to fight inflammatory diseases including rheumatoid arthritis, Crohn's disease, physical wasting, and graft-versus-host disease. The protein may help counteract the ill effects when the body produces excessive amounts of another protein key to fighting infection.

In proper balance, a bodily protein called tumor necrosis factor alpha performs like a hero, helping to fight infections and other bodily invaders. But like a hero gone awry, excessive TNF production stimulated by TNF itself can cause a host of inflammatory ills, such as those mentioned above, and the physical wasting that accompanies many cancers and AIDS.

Now, however, scientists at the National Institute of Environmental Health Sciences have identified a protein that can put the brakes on TNF.

Using genetically modified mice with a specific gene removed, researchers at the National Institute of Environmental Health Sciences have identified a protein that counters TNF, that in turn may lead to drugs that will curb TNF's ravages. This protein is called Tristetraprolin, or TTP.

In previous experiments, the researchers found that mice genetically modified to remove the TTP gene suffer many ailments similar to those associated with overproduction of TNF in people; yet when TNF is controlled in the mice, most of the TNF-induced problems do not develop. In their new study, published in Science (Vol. 281, p. 1001), the researchers found that this overproduction of TNF in the TTP deficient mice was due to the absence of TTP's controlling effect on TNF's synthesis by inflammatory cells.

Authors of the study are Ester Carballo, M.D., Ph.D., and Wi S. Lai, Ph.D., both of the Laboratory of Signal Transduction, NIEHS, and Perry J. Blackshear, M.D., D.Phil., Director of Clinical Research, NIEHS.

Dr. Blackshear said that TTP appears to regulate production
'"/>

Contact: Tom Hawkins
hawkins@niehs.nih.gov
(919) 541-1402
NIH/National Institute of Environmental Health Sciences
9-Sep-1998


Page: 1 2

Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. NIEHS and UNC to collaborate on registry of 20,000 subjects
3. NIEHS-funded researchers find low-level ozone increases respiratory risk of asthmatic children
4. NIEHS study identifies gene for hydrocephalus in mice
5. NIEHS, NTP director receives honorary doctorate
6. Advisory panel on federal report on carcinogens makes recommendations to NIEHS/NTP for new listings
7. NIEHS urges safety workers to prepare for Y2K false alarms and malfunctions
8. NIEHS-cloned gene linked to a natural substance that reduces vascular inflammation, a key to arterial clogging
9. NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility
10. Three-Way Gene-Gene-Environmental Exposure Interaction Shown By NIEHS To Escalate Smoking-Related Bladder Cancer
11. Very-Low-Fat Diet May Compromise Immune Function, Increase Infection Risk In Trained Runners, UB Study Finds

Post Your Comments:
(Date:6/24/2015)... Research and Markets( ... "Huawei Ascend Mate 7 Fingerprint Sensor - ... Huawei,s technological choice for the fingerprint ... Apple,s and Samsung,s one. The Ascend Mate 7 ... Cards, a main actor in capacitive sensing human ...
(Date:6/23/2015)... 23, 2015   MedNet Solutions , an ... entire spectrum of clinical research, is pleased to ... , the company,s intuitive, flexible and affordable cloud-based ... 2015 Stevie® Award by the American Business ... Website category.  The American Business Awards are considered ...
(Date:6/23/2015)... 2015   Valencell, a leader in ... a recent study that illustrates its PerformTek biometric ... activity. In a study conducted at Valencell,s Biometric ... the Apple Watch against a chest strap – ... activity. The study demonstrated that Valencell,s biometric technology ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3
(Date:7/1/2015)... BANGALORE, India , July 1, 2015 /PRNewswire/ ... uses next generation sequencing technology to empower cancer care, ... as chief executive officer. In his expanded role ... for all strategy, business expansion and worldwide operations effective ... as Strand,s chairman and CEO since its founding in ...
(Date:7/1/2015)... InferMed , s ... will augment ... s olutions suite   Elsevier , ... and services, announced today the acquisition of  InferMed , a ... company. InferMed,s Arezzo technology supports clinicians in choosing ...
(Date:6/30/2015)... ... 2015 , ... Students and faculty from Beijing City University ... “Integrative Biotechnology,” an applied biotechnology course team-taught by faculty members from both institutions. ... from both universities and is taught on both continents. , “Our alliance with ...
(Date:6/30/2015)... 30, 2015  Today, Americord Registry, one of the fastest ... Horne , a partner at Kirkland & Ellis LLP, as ... Logo - http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We are thrilled ... says Martin Smithmyer , CEO of Americord. "He brings ... that will assist Americord,s growth and vision." ...
Breaking Biology Technology:Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2Americord Registry Announces Andrew Horne as Advisory Board Member 2
Cached News: