NIEHS Finds Protein That Counteracts Inflammation And Wasting That May Target,,Rheumatoid Arthritis And Crohn's Disease

Scientists at NIEHS have identified a protein which may help in the quest for drugs to fight inflammatory diseases including rheumatoid arthritis, Crohn's disease, physical wasting, and graft-versus-host disease. The protein may help counteract the ill effects when the body produces excessive amounts of another protein key to fighting infection.

In proper balance, a bodily protein called tumor necrosis factor alpha performs like a hero, helping to fight infections and other bodily invaders. But like a hero gone awry, excessive TNF production stimulated by TNF itself can cause a host of inflammatory ills, such as those mentioned above, and the physical wasting that accompanies many cancers and AIDS.

Now, however, scientists at the National Institute of Environmental Health Sciences have identified a protein that can put the brakes on TNF.

Using genetically modified mice with a specific gene removed, researchers at the National Institute of Environmental Health Sciences have identified a protein that counters TNF, that in turn may lead to drugs that will curb TNF's ravages. This protein is called Tristetraprolin, or TTP.

In previous experiments, the researchers found that mice genetically modified to remove the TTP gene suffer many ailments similar to those associated with overproduction of TNF in people; yet when TNF is controlled in the mice, most of the TNF-induced problems do not develop. In their new study, published in Science (Vol. 281, p. 1001), the researchers found that this overproduction of TNF in the TTP deficient mice was due to the absence of TTP's controlling effect on TNF's synthesis by inflammatory cells.

Authors of the study are Ester Carballo, M.D., Ph.D., and Wi S. Lai, Ph.D., both of the Laboratory of Signal Transduction, NIEHS, and Perry J. Blackshear, M.D., D.Phil., Director of Clinical Research, NIEHS.

Dr. Blackshear said that TTP appears to regulate production

Contact: Tom Hawkins
(919) 541-1402
NIH/National Institute of Environmental Health Sciences

Page: 1 2

Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. NIEHS and UNC to collaborate on registry of 20,000 subjects
3. NIEHS-funded researchers find low-level ozone increases respiratory risk of asthmatic children
4. NIEHS study identifies gene for hydrocephalus in mice
5. NIEHS, NTP director receives honorary doctorate
6. Advisory panel on federal report on carcinogens makes recommendations to NIEHS/NTP for new listings
7. NIEHS urges safety workers to prepare for Y2K false alarms and malfunctions
8. NIEHS-cloned gene linked to a natural substance that reduces vascular inflammation, a key to arterial clogging
9. NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility
10. Three-Way Gene-Gene-Environmental Exposure Interaction Shown By NIEHS To Escalate Smoking-Related Bladder Cancer
11. Very-Low-Fat Diet May Compromise Immune Function, Increase Infection Risk In Trained Runners, UB Study Finds

Post Your Comments:

(Date:10/26/2015)... and LAS VEGAS , ... Nok Labs , an innovator in modern authentication and ... today announced the launch of its latest version of ... platform enabling organizations to use standards-based authentication that supports ... Nok S3 Authentication Suite is ideal for organizations deploying ...
(Date:10/23/2015)... California , October 23, 2015 ... (SMI) announce a mobile plug and play integration of ... real-world tasks SensoMotoric Instruments (SMI) present ... wearable solutions for eye tracking and physiological data registration. ... SMI Eye Tracking Glasses 2w and physiological ...
(Date:10/22/2015)... 2015 About fingerprint biometrics ... individual with the database to identify and verify an ... loop. Pattern-based algorithms are used to match an individual,s ... was introduced in 1986, which is being used by ... criminal. Technavio,s analysts forecast the global fingerprint ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... The Academy of Model Aeronautics (AMA), ... MultiGP, also known as Multirotor Grand Prix, to represent the First–Person View (FPV) racing ... AMA members have embraced this type of racing and several new model aviation pilots ...
(Date:11/24/2015)... QUEBEC CITY , Nov. 24, 2015 /PRNewswire/ ... (the "Company") announced today that the remaining 11,000 ... Common Share Purchase Warrants (the "Series B Warrants") ... agreement were exercised on November 23, 2015, which ... Common Shares.  After giving effect to the issuance ...
(Date:11/24/2015)... ... November 24, 2015 , ... Creation Technologies would like ... to Deloitte's 2015 Technology Fast 500 list of the fastest growing companies in ... Class II medical device that speeds up orthodontic tooth movement by as much ...
(Date:11/24/2015)... INCLINE VILLAGE, Nev. , Nov. 24, 2015  PDL ... John P. McLaughlin , the company,s president and chief ... Piper Jaffray Healthcare Conference next week in New ... and will occur on Tuesday, December 1, 2015 at 9:30 ... and Presentations." Please connect to the website at least 15 ...
Breaking Biology Technology:
Cached News: