NIEHS-cloned gene linked to a natural substance that reduces vascular,,inflammation, a key to arterial clogging

Scientists at National Institute of Environmental Health Sciences, Brigham and Women's Hospital in Boston, and the University of Virginia have shown that naturally occurring fatty acids can help prevent vascular inflammation, a key component in the development of atherosclerosis-- the so-called "hardening" of the arteries that leads to many heart attacks and strokes.

The fatty acids are made by an enzyme produced by a gene first cloned at NIEHS -- and the gene itself, when implanted in the arterial cells, can produce the same protective effect, the researchers said.

The findings were published in the journal Science.

The fatty acid studies were performed in cultured human cells (from the lining of the arteries) and in live mice. They show that the introduction of fatty acid compounds called EETs can suppress the inflammation of arteries and may thereby protect against the development of atherosclerosis.

James Liao, M.D., of the Harvard-associated Brigham and Women's Hospital, said EETs may also be important in some cancers and rheumatic diseases where inflammatory cells have a role.

Darryl C. Zeldin, M.D., of NIEHS, a senior co-author on the study, originally cloned the CYP2J2 gene. "Since our studies have thus far been limited to tissue cultures and mice, we are still at a very early phase of discovery on the anti-inflammatory potential of the EETs and their stable analogs in humans," Zeldin said, "but the results show exciting potential."

Indeed, Liao said, "EETs may be the next generation of molecules that can be used to combat atherosclerosis and other diseases arising from inflammation." Atherosclerosis, a thickening and build-up of plaque in the arteries, occurs when the innermost layer of the artery, the endothelium, becomes damaged by cholesterol, toxins, oxidants, or infectious agents.

The damaged endothelial cells in the artery walls produce adhes

Contact: Bill Grigg or Tom Hawkins
NIH/National Institute of Environmental Health Sciences

Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
3. Protein involved in childhood disorder linked to cancer
4. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
5. Gene linked to cleft lip and palate identified
6. Schizophrenia gene variant linked to risk traits
7. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
8. Excess levels of nitrogen, phosphorus linked to deformed frogs
9. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
10. LBP-1a gene mutation linked to disruption of normal fetal development
11. Outcome for acute lymphoblastic leukemia linked to gene expression patterns

Post Your Comments:

(Date:7/18/2020)... ... July 16, 2020 , ... A study has ... Invictus Medical Neoasis™ active noise control device to attenuate typical noises in a ... device attenuated the alarm sounds from patient monitors, ventilators and other bedside devices ...
(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical (ABM), a ... awards for not only the products and treatments developed, but also the dedicated ... RF. All the brands built by ABM have received several honors already for ...
(Date:7/1/2020)... VENICE, Calif. (PRWEB) , ... July 01, 2020 ... ... focused on building awareness and solutions for glioblastoma—the most common and aggressive adult ... and Lisa Haile, JD, PhD. Senior Fellows are charged with supporting the organization’s ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 09, 2020 , ... In most research using the zebrafish ... formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the ... using the zebrafish model to investigate the causes of leukaemia and its relationship ...
(Date:7/7/2020)... ... 2020 , ... R3 International is now offering stem cell therapy for Alzheimers ... Depending on the patient's condition, treatment may be offered IV, intrathecal or with a ... of Alzheimers dementia, and the incidence continues to increase as individuals live longer. There ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... date growth of 40% in 2020, despite many obstacles created as a result ... to increase revenue for its partnered medical practices and medical manufacturers by expanding ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... insights, today announced that the launch of a new clinical diagnostics ... about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that ...
Breaking Biology Technology:
Cached News: