HOME >> BIOLOGY >> NEWS
NIGMS Structural Genomics Awards scale up protein structure studies

If genes are the recipes for life, then proteins are the culinary result--the very stuff of life. Proteins control many biological processes in organisms ranging from bacteria to plants and humans. One way to understand proteins--and perhaps find ways to control their action--is to decipher their three-dimensional structures.

The National Institute of General Medical Sciences (NIGMS) has developed a major new initiative to determine the structures of thousands of proteins over the next decade. Work toward this goal will be divided into two phases: a five-year pilot stage and a subsequent five-year full-scale production phase. The initial phase begins with today's announcement of the first awards for pilot research centers in structural genomics, a new field dedicated to a broad understanding of protein structures and functions in relation to gene sequences.

NIGMS is awarding almost $30 million this year to seven projects, each totaling around $4 million for the first year. The Institute anticipates spending a total of around $150 million on these projects over five years, making NIGMS the world's single largest funder of structural genomics.

"This project can be viewed as an inventory of all the protein structure families that exist in nature," said Dr. Marvin Cassman, NIGMS Director. "We expect that this effort will yield major biological findings that will improve our understanding of health and disease."

Structural genomics, which builds on genome sequencing efforts, can teach us fundamental lessons about biology and can advance efforts in structure-based drug design. For example, the structure of a disease-related protein can provide insight into how the protein works normally and how a faulty structure can cause disease. This same structure may reveal how to design drugs to treat that disease.

Although structure determination techniques--chiefly X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy--have
'"/>

Contact: Alisa Machalek
machalea@nigms.nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
25-Sep-2000


Page: 1 2 3 4

Related biology news :

1. NIGMS funds Center for Quantitative Biology
2. Lipids get the spotlight in new NIGMS Glue Grant
3. NIGMS center grants will spice up chemical libraries
4. NIGMS and NSF grants join math and biology
5. NIGMS energizes NMR research with worlds biggest magnets
6. NIGMS awards Glue Grant to create virtual cell
7. NIGMS Makes First Awards For
8. Structural mechanism of cell enzyme revealed by UT Southwestern researchers
9. Structural studies reveal how potassium channels are inactivated
10. Argonne leads new Midwest Center for Structural Genomics
11. NIH launches first center in Nationwide Chemical Genomics Network

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... FREDERICK, Md. (PRWEB) , ... ... ... a leading provider of gene-to-protein and monoclonal antibody development services, today announced ... of protein-based products and services to the pharmaceutical, diagnostics, and research industries. ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... instrumentation, is pleased to announce the next event in a series of TOPIQ ... , The TOPIQ series of webinars was developed in response to social distancing ...
(Date:6/19/2020)... (PRWEB) , ... June 18, ... ... three-part webinar series, “Automate Your Lab with Software for Data Decisions,” for ... will learn how to integrate and automate cutting-edge scientific instruments and laboratory ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 17, 2020 , ... ... the life sciences and food industries, is pleased to announce that Charles Galea ... – Business Development. , Charles is an accomplished and results-driven sales executive with ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research ... to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic ... MA has been using the zebrafish model to investigate the causes of leukaemia ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has ... Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and ... elite awards program, highlighting outstanding examples of how technology innovations and strategic initiatives ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... insights, today announced that the launch of a new clinical diagnostics ... about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that ...
Breaking Biology Technology:
Cached News: