HOME >> BIOLOGY >> NEWS
NIGMS center grants will spice up chemical libraries

ng director of NIGMS. "Ready access to these new methods will give biologists, in collaboration with chemists, the ability to obtain combinatorial libraries that are tailor-made to meet their specific research needs."

According to Dr. John M. Schwab, the NIGMS chemist who spearheaded the initiative, "Combinatorial chemistry uses massively parallel synthesis to rapidly assemble libraries. We are looking for new, highly efficient methods for synthesis, separation, purification, and analysis that will accelerate the creation of libraries and enable a broader range of structures to be made."

"Another key feature of the CMLD program is that each center must be highly integrated, featuring collaborative, synergistic projects," said Schwab. "This is not typical in the academic chemistry community. But experience has shown that unique insights can be gained when scientists approach a project from different perspectives."

The initiative comes at an opportune time, because recently developed automated screening tools allow scientists to sift through massive collections of compounds in short order. This approach was quickly adopted by the pharmaceutical industry, which routinely uses it to discover bioactive compounds that potentially could be developed into new drugs. Although industry has embraced the use of combinatorial chemistry, it rarely publishes new methods for generating libraries.

Of the chemical libraries that are available to the entire scientific community, many have been assembled using a small number of methods and core chemical scaffolds. That means they contain limited variety. The NIGMS effort seeks to enable the creation of truly unique and diverse, high-quality libraries through the development of new chemical methods. That, said Schwab, "will produce lasting benefits for all of biomedical science."


'"/>

Contact: Alisa Zapp Machalek
alisa.machalek@nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
10-Oct-2002


Page: 1 2

Related biology news :

1. NIGMS funds Center for Quantitative Biology
2. Lipids get the spotlight in new NIGMS Glue Grant
3. NIGMS and NSF grants join math and biology
4. NIGMS energizes NMR research with worlds biggest magnets
5. NIGMS Structural Genomics Awards scale up protein structure studies
6. NIGMS awards Glue Grant to create virtual cell
7. NIGMS Makes First Awards For
8. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
9. New Arizona State center brings science to policy on issues of water resources and urban growth
10. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
11. Brain has center for detecting sound motion

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... Systems, Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & ... intelligence provider visiongain offers comprehensive analysis of ... that this market will generate revenues of $17.98 billion ... Systems acquired DVTEL Inc, a leader in software and ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... June 23, 2016 On Wednesday, June ... 4,833.32, down 0.22%; the Dow Jones Industrial Average edged 0.27% ... at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the ... Nektar Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. ... BIND ). Learn more about these stocks by ...
(Date:6/23/2016)... ... 2016 , ... Velocity Products, a division of Morris Group, ... exclusively for Okuma CNC machining centers at The International Manufacturing Technology Show, IMTS, ... companies with expertise in toolholding, cutting tools, machining dynamics and distribution, Velocity SMART ...
Breaking Biology Technology:
Cached News: