NIGMS center grants will spice up chemical libraries

ng director of NIGMS. "Ready access to these new methods will give biologists, in collaboration with chemists, the ability to obtain combinatorial libraries that are tailor-made to meet their specific research needs."

According to Dr. John M. Schwab, the NIGMS chemist who spearheaded the initiative, "Combinatorial chemistry uses massively parallel synthesis to rapidly assemble libraries. We are looking for new, highly efficient methods for synthesis, separation, purification, and analysis that will accelerate the creation of libraries and enable a broader range of structures to be made."

"Another key feature of the CMLD program is that each center must be highly integrated, featuring collaborative, synergistic projects," said Schwab. "This is not typical in the academic chemistry community. But experience has shown that unique insights can be gained when scientists approach a project from different perspectives."

The initiative comes at an opportune time, because recently developed automated screening tools allow scientists to sift through massive collections of compounds in short order. This approach was quickly adopted by the pharmaceutical industry, which routinely uses it to discover bioactive compounds that potentially could be developed into new drugs. Although industry has embraced the use of combinatorial chemistry, it rarely publishes new methods for generating libraries.

Of the chemical libraries that are available to the entire scientific community, many have been assembled using a small number of methods and core chemical scaffolds. That means they contain limited variety. The NIGMS effort seeks to enable the creation of truly unique and diverse, high-quality libraries through the development of new chemical methods. That, said Schwab, "will produce lasting benefits for all of biomedical science."


Contact: Alisa Zapp Machalek
NIH/National Institute of General Medical Sciences

Page: 1 2

Related biology news :

1. NIGMS funds Center for Quantitative Biology
2. Lipids get the spotlight in new NIGMS Glue Grant
3. NIGMS and NSF grants join math and biology
4. NIGMS energizes NMR research with worlds biggest magnets
5. NIGMS Structural Genomics Awards scale up protein structure studies
6. NIGMS awards Glue Grant to create virtual cell
7. NIGMS Makes First Awards For
8. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
9. New Arizona State center brings science to policy on issues of water resources and urban growth
10. Environmental issues center of Inland Northwest Research Alliance 4th Annual Symposium
11. Brain has center for detecting sound motion

Post Your Comments:

(Date:10/29/2015)... Oct. 29, 2015 Daon, a global leader ... has released a new version of its IdentityX ... North America have already installed IdentityX ... includes a FIDO UAF certified server component ... to activate FIDO features. These customers include some of ...
(Date:10/27/2015)... 27, 2015 In the present market scenario, ... for various industry verticals such as banking, healthcare, defense, ... growing demand for secure & simplified access control and ... as hacking of bank accounts, misuse of users, , ... as PC,s, laptops, and smartphones are expected to provide ...
(Date:10/26/2015)... NEWARK, Calif. , Oct. 26, 2015  Delta ... convenient biometric authentication to mobile and PC devices, announced ... Fujitsu,s smartphone, the arrows NX F-02H launched by NTT ... arrows NX F-02H is the second smartphone to include ... this technology in ARROWS NX F-04G in May 2015, ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... 2015 --> ... companion diagnostics is one of the major ... pharmaceutical companies and diagnostic manufacturers working together ... http://www.rnrmarketresearch.com/global-cancer-biomarkers-market-2015-2019-market-report.html . --> http://www.rnrmarketresearch.com/global-cancer-biomarkers-market-2015-2019-market-report.html ... global cancer biomarkers market spread across 89 ...
(Date:11/25/2015)... 26, 2015 --> ... 2016 - 2020 report analyzes that automating biobanking ... quality in long-term samples, minimizing manual errors, improving ... minimizes manual errors such as mislabeling or inaccurate ... it plays a vital role in blood fractionation, ...
(Date:11/25/2015)... Studies reveal the differences in ... pave the way for more effective treatment for one of ...   --> --> Gum ... in cats, yet relatively little was understood about the bacteria ... been conducted by researchers from the WALTHAM Centre for Pet ...
(Date:11/25/2015)... QUEBEC CITY , Nov. 25, 2015 /PRNewswire/ ... "Company"), affirms that its business and prospects remain ... , Zoptrex™ (zoptarelin doxorubicin) recently received DSMB ... program to completion following review of the final ... met Phase 2 Primary Endpoint in men with ...
Breaking Biology Technology:
Cached News: