HOME >> BIOLOGY >> NEWS
NIH awards UCSF $12 million in new national effort to learn how genes affect people's repsonses to medicines

As the high-profile effort to decipher the human genome nears completion, scientists nationwide are launching another ambitious project -- this time to learn how variations in genes affect people's responses to drugs. Differences of a single "letter" among many thousands in the DNA instructions of a gene are thought to often affect drug response. The emerging research, in the field known as pharmacogenetics, is expected to revolutionize the way drugs are designed and tested, boost the effectiveness of drug treatments and cut the likelihood of side effects.

A team of more than 20 scientists at UC San Francisco has received an $11.9-million research grant -- the largest among nine awarded this week by the National Institutes of Health in the first phase of a major new pharmacogenetics research initiative. The national project aims to identify the genetic differences that determine why some people can be successfully treated with a drug while others with the same condition remain unaffected or are even harmed by the drug. The four-year UCSF study involves laboratory and clinical research to determine how natural genetic variation affects the performance of human proteins known as membrane transporters which act as cellular gatekeepers, controlling whether drugs get into the blood stream.

"Our ultimate goal is to able to read someone's DNA and know what drugs to use and at what doses, as well as which drugs to avoid," says Kathleen Giacomini, PhD, professor and chair of biopharmaceutical sciences at UCSF and the leader of the transporter study. "Transporter proteins are one of the keys to drug response, and that's why we are looking for the genetic variants among them." Giacomini, a leader in studies of how transporters affect absorption and elimination of drugs in the body, last year was awarded the Pharmaceutical Scientist of the Year Award by the International Pharmaceutical Federation in recognition of her research.

The UCSF project, totaling about $3.
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
3-Apr-2000


Page: 1 2 3

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
3. NSF awards 22 new projects for plant genome research
4. The American Phytopathological Society announces 2004 awards
5. NSF announces six FIBR awards to tackle some of biologys most challenging questions
6. Two Virginia Tech energy-related inventions win R&D 100 awards
7. APS awards more than $140,000 to minority students of physiology
8. APS awards more than $36,000 to its 2004 undergraduate research fellows
9. 8 environmental stewards win $900,000 in biodiversity awards
10. UCSB professor and director receives two national awards
11. NSF awards $10 million in grants to ocean sites for long-term ecological research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... ... February 13, 2019 , ... MMJ International Holdings, the ... through patient clinical trials and research, announced that it is seeking fast track ... to help expedite the review and approval of drugs in development that treat ...
(Date:2/11/2019)... ... February 11, 2019 , ... Allotrope Foundation announces ... phased release of the Allotrope™ Framework for standardizing scientific data and its context. ... Allotrope™ Data Format (ADF) and application programming interfaces (APIs), and the Allotrope Foundation© ...
(Date:2/2/2019)... ... 31, 2019 , ... Through its Microbiome Grant Initiative ... study design, planning, sample collection, and analysis to researchers at Stanford University led ... Sara Vaughn, MD, Reproductive Endocrinology and Infertility Fellow, to study the role of ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... January 29, 2019 , ... ... is frustrated over something like a tricky math problem on an online tutoring ... by Worcester Polytechnic Institute (WPI) computer science assistant professor Erin Solovey ...
(Date:1/24/2019)... ... January 22, 2019 , ... Controlled Contamination Services is pleased to announce three ... of these valuable new team members will support its growing operation across the US ... CCS scales its business. This addition will enable CCS to widen its reach and ...
(Date:1/20/2019)... (PRWEB) , ... January 16, 2019 , ... On January ... an invited news article by Asymmetrex director James L. Sherley, M.D., Ph.D. ... cell therapy resources like the PGCB and CellTrials.org. Now in its 21st year ...
(Date:1/15/2019)... ... January 15, 2019 , ... Personalized treatment plans may extend life expectancy ... to a new study published in the journal Radiology. , Kidney, or renal, ... nephrectomy, a surgical procedure in which the tumor and part of the kidney are ...
Breaking Biology Technology:
Cached News: