HOME >> BIOLOGY >> NEWS
NIH funds new Boston College-Boston University study of B-1a cell associated with leukemia

BC Biology Professor Thomas Chiles and Colleagues at BU Medical Center Awarded NIH Program Project Grant to Study Type of White Blood Cell Associated with Lymphocytic Leukemia

Boston College Biology Professor Thomas Chiles and colleagues at Boston University Medical Center have been awarded a five-year, approximately $4.5-million program project grant from the National Institutes of Allergy and Infectious Disease of the National Institutes of Health (NIH). The research will focus on understanding the growth and differentiation of a small subset of white blood cells called B-1a lymphocytes (B-1a cells).

B-1a cells, which are found in the peritoneal cavity, and B-2 cells, which are located in the spleen and lymph nodes, defend the body against infectious disease. However, an over-production of B-1a cells can lead to autoimmune diseases and leukemias.

Research by Chiles' group at Boston College, working with Dr. Thomas Rothstein of Boston University's Department of Medicine, previously demonstrated that the rules that govern cell cycle control and differentiation to immunoglobulin-secreting plasma cells are different in B-1a cells than in B-2 cells.

As part of the new NIH-funded program project, research carried out at Boston College will seek to better understand the molecular mechanisms that control when B-1a cells enter the cell cycle and proliferate.

Insights from these studies will help us understand the molecular basis of several human lymphoproliferative disorders associated with B-1a cells, including a form of cancer called chronic lymphocytic leukemia.


'"/>

Contact: Thomas Chiles
thomas.chiles@bc.edu
617-552-0840
Boston College
13-May-2004


Page: 1

Related biology news :

1. NIGMS funds Center for Quantitative Biology
2. $5 million grant funds partnership, studies of minority-based issues in reproductive health
3. NSF funds summer research program abroad for undergraduates at UC San Diego
4. Research to create lung-cancer blood tests receives $3.4M in Pennsylvania tobacco settlement funds
5. The DFG funds a new research vessel
6. NIH funds Breast Cancer and the Environmental Research Center at Fox Chase Cancer Center
7. Grant funds research to develop tissue-engineered solutions for heart disease
8. Stuart research funds generating dividends for veterinary medicine
9. Grant funds research to develop microbicide barrier to HIV
10. $24-million grant funds local researchers to create encyclopedia of the innate immune system
11. NIH funds new AIDS drug discovery research with $4.6 million

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2018)... ... December 06, 2018 , ... Stewart has been on the ... throughout his career. During his recent five-year tenure with InSphero he was the ... commercial laboratory operations in Brunswick, Maine. Through these experiences, Stewart has a deep ...
(Date:12/5/2018)... ... December 03, 2018 , ... ... an emerging leader in the distribution and marketing of cutting-edge aesthetic devices in ... $20MM in sales for 2018. Cartessa’s success can be attributed in-part to ...
(Date:12/5/2018)... ... 2018 , ... Biolytic Lab Performance Inc. is proud to ... Biolytic’s Molecule Synthesis Platform. , Now restructured with all the same principles ... in oligonucleotide synthesis, the 192c incorporates a multitude of enhancements to new and ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... Leading authority ... an all-new, how-to guide with his “The Referral Playbook: How to Increase Sales ... of the book proceeds will go to the Alzheimer’s Foundation of America (AFA). ...
(Date:11/28/2018)... SAN DIEGO, CALIF. (PRWEB) , ... November 28, 2018 , ... ... learn more about Italian cuisine, as well as experience the height of truffle season. ... for its delicious food and pristine countryside. Staying in the exclusive Black Truffle Lodge ...
(Date:11/20/2018)... , ... November 20, 2018 , ... Each year Forbes ... Under 30 list which highlights outstanding performance by individuals under 30 years of age. ... range of fields from Sports and Entertainment to Venture Capital and Science. , ...
(Date:11/13/2018)... ... November 12, 2018 , ... Dr. Dan ... and Sandy Springs, now welcomes new patients for MTM® Clear Aligners. Offering a ... to traditional braces in the Sandy Springs and Alpharetta areas. Constantly on the ...
Breaking Biology Technology:
Cached News: