HOME >> BIOLOGY >> NEWS
NRH1 and Wnt signaling come together in convergent extension

The African clawed frog, Xenopus laevis, begins development as a compact ball of cells that undergoes a dramatic transformation through cell migrations and positional rearrangements that result in the separation of the embryo into three distinct germ layers, which go on to give rise to all of the tissues and structures in the adult animal's body. During this transformation, known as gastrulation, the embryo changes from a roughly spherical shape to an elongated, streamlined form through a process called convergent extension (CE), in which polarized cells migrate to and merge at the embryo's midline, driving it to lengthen along its anterior-posterior axis.

A number of genes involved in the regulation of convergent extension have been identified in amphibians and other vertebrates, such as zebrafish, but the picture of the underlying molecular mechanisms remains incomplete. Researchers at the RIKEN Center for Developmental Biology (CDB; Kobe, Japan) have now added a new piece to the puzzle. In a report published in the advanced online edition of Nature Cell Biology, Noriaki Sasai and colleagues in the Laboratory for Organogenesis and Neurogenesis (Group Director, Yoshiaki Sasai) show that the product of the gene NRH1 is essential to the regulation of CE movements in the frog.

While performing a screen of genes expressed in the posterior neuroectoderm, Sasai et al. identified a gene encoding a protein that showed similarities to p75NTR, a neurotrophin receptor. (Neurotrophins are molecules that function in the survival, growth and migration of neurons.) However, on testing its affinity for neurotrophin ligands, the group found that, unlike p75NTR, NRH1 did not bind with neurotrophins, which led them to seek other biological roles for the protein.

Experiments in which NRH1 was overexpressed by injecting its messenger RNA directly into very early (4-cell stage) embryos resulted in shortening of the body axis and the failure of mesodermal and neu
'"/>

Contact: Doug Sipp
sipp@cdb.riken.jp
81-78-306-3043
RIKEN Center for Developmental Biology
20-Jul-2004


Page: 1 2 3

Related biology news :

1. Activated signaling pathway may predict lung cancer patients response to gefitinib
2. From lung to gut the Wnt signaling pathway transforms cell fate
3. Equine clonings triple play sheds light on calcium, cell signaling, human disease
4. UT Southwestern researchers learn importance of insulin family signaling in male sex determination
5. Mantis shrimp fluoresce to enhance signaling in the dim ocean depths
6. OHSU researchers discover molecular signaling system controlling aspects of embryonic development
7. New study identifies gene signaling puberty
8. Are the bright colors of some avian eggs signaling female genetic quality to their mates?
9. Scientists map signaling molecule crucial to survival, disease
10. Researchers identify molecular signaling system that is crucial for plant fertility
11. Plants and people share a molecular signaling system, researchers discover

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... JUPITER, Fla. (PRWEB) , ... June 25, 2020 , ... ... will focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local ... labs. Samples are collected at medical offices and are shipped to labs throughout the ...
(Date:6/23/2020)... TORONTO (PRWEB) , ... June 22, 2020 , ... The ... time. Typically, ligand binding assays (LBA) have dominated this area. However, the use of ... several years. , This now necessitates the question “How do you choose which approach ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... Lab with Software for Data Decisions,” for pharmaceutical and biotech executives, laboratory ... and automate cutting-edge scientific instruments and laboratory equipment from dozens of manufacturers ...
Breaking Biology News(10 mins):
(Date:6/11/2020)... BALTIMORE (PRWEB) , ... June 09, 2020 , ... ... completion of Phase I of a Small Business Innovation Research (SBIR) program funded ... the 21st Century: Rapid Toxin Detection in the Field”. The project’s goal was ...
(Date:6/3/2020)... ... , ... Thought Technology Ltd. is offering a free webinar ... Inna Khazan will discuss the benefits of using mindfulness techniques with biofeedback. Mindfulness ... thoughts, and emotions they are having in the present moment and to respond ...
(Date:5/30/2020)... ... May 29, 2020 , ... The Conference Forum is pleased ... dedicated to the unique role of the Chief Medical Officer in the biotech ... problem-solving, best practices and career development of CMOs and Heads of R&D from ...
(Date:5/26/2020)... PARK, Calif. (PRWEB) , ... May 26, 2020 , ... ... , the most recognized brand of smart garage door openers, announce a new integration ... line of Wi-Fi enabled garage door openers powered by Aladdin Connect® can now be ...
Breaking Biology Technology:
Cached News: